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Disulfiram Implantation: Placebo, Psychological Deterrent, and Pharmacological Deterrent Effects

Published online by Cambridge University Press:  29 January 2018

Allan Wilson ,
William J. Davidson  and
John White
Allan Wilson
Affiliation:
Department of Psychiatry, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Canada R3E 0W3
William J. Davidson
Affiliation:
Department of Pharmacology and Therapeutics, University of Manitoba
John White
Affiliation:
Department of Psychiatry, University of Manitoba
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Summary

In an effort to examine the placebo, psychological deterrent, and pharmacological deterrent effects associated with implanted disulfiram, subjects were given either disulfiram implants or sham operations. Ethanol challenges elicited no disulfiram-ethanol reactions (DERs), indicating that at the time of the challenge neither a pharmacological deterrent nor a placebo effect was operating. Of the patients who resumed drinking, only those with disulfiram implants experienced DERs. Sham operation subjects continued to drink after their first post-challenge drink; four of five disulfiram implant recidivists remained abstinent following their experience of a DER. It is concluded that the pharmacological deterrent effect of the disulfiram implant may have been underestimated in previous reports.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 129 , Issue 3 , September 1976 , pp. 277 - 280
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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References

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