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Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis: commentary, Green et al

Published online by Cambridge University Press:  21 July 2025

Jessica Emily Green Open the ORCID record for Jessica Emily Green [Opens in a new window] ,
Anna Wrobel Open the ORCID record for Anna Wrobel [Opens in a new window] ,
Emma Todd ,
Wolfgang Marx ,
Michael Berk Open the ORCID record for Michael Berk [Opens in a new window] ,
Mojtaba Lotfalian ,
David Castle ,
John F. Cryan ,
Eugene Athan  and
Christopher Hair
...Show all authors
Jessica Emily Green*
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia Monash Alfred Psychiatry Research Centre (MAPrc), Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Prahran, Australia Department of Gastroenterology, Street Vincents Hospital Melbourne, Fitzroy, Australia Barwon Health, Geelong, Australia
Anna Wrobel
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia
Emma Todd
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia
Wolfgang Marx
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia
Michael Berk
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia Barwon Health, Geelong, Australia Department of Psychiatry, University of Melbourne, Parkville, Australia Orygen Youth Health Research Centre and the Centre of Youth Mental Health, Melbourne, Australia The Florey Institute for Neuroscience and Mental Health, Parkville, Australia
Mojtaba Lotfalian
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia
David Castle
Affiliation:
University of Tasmania, Hobart, Tasmania
John F. Cryan
Affiliation:
Department of Anatomy and Neuroscience, University College Cork and APC Microbiome, Ireland
Eugene Athan
Affiliation:
Barwon Health, Geelong, Australia
Christopher Hair
Affiliation:
Barwon Health, Geelong, Australia
Andrew A. Nierenberg
Affiliation:
Dauten Family Center for Bipolar Treatment Innovation, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA
Felice N. Jacka
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia James Cook University, Townsville, Australia
Samantha Dawson
Affiliation:
Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Australia
*
Correspondence: Jessica Emily Green. Email: jegreen@deakin.edu.au
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Abstract

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Keywords

Antibiotic exposuremental healthsystematic reviewmeta-analysisearly life

Information

Type
Commentary
Information
The British Journal of Psychiatry , Volume 227 , Issue 1 , July 2025 , pp. 511 - 512
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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Footnotes

*

Joint senior authors.

References

Sethi, FA, Hanif, W. Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis: commentary, Sethi et al. Br J Psychiatry 2025; 1–2. Available from: https://doi.org/10.1192/bjp.2025.37.Google Scholar
Green, JE, Wrobel, A, Todd, E, Marx, W, Berk, M, Lotfaliany, M, et al. Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis. Br J Psychiatry 2025; 226: 171–83.CrossRefGoogle ScholarPubMed
Yousefifard, M, Shafiee, A. Should the reporting certainty of evidence for meta-analysis of observational studies using GRADE be revisited? Int J Surg 2023; 109: 129–30.CrossRefGoogle ScholarPubMed
Solmi, M, Radua, J, Olivola, M, Croce, E, Soardo, L, Salazar de Pablo, G, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry 2022; 27: 281–95.CrossRefGoogle ScholarPubMed
Atladóttir, H, Henriksen, TB, Schendel, DE, Parner, ET. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics 2012; 130: e1447–54.CrossRefGoogle ScholarPubMed
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