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Effect of Serum from Schizophrenics on Evoked Cortical Potentials in the Rat

Published online by Cambridge University Press:  29 January 2018

D. Stenhouse
Affiliation:
Department of Physiology, University of Aberdeen
R. Antebi
Affiliation:
Royal Cornhill Hospital, Aberdeen
E. M. A. Dear
Affiliation:
Department of Physiology, University of Aberdeen
R. N. Herrington
Affiliation:
Department of Physiology, University of Aberdeen
C. McCance
Affiliation:
Royal Cornhill Hospital, Aberdeen

Extract

German (1961, 1963) reported that serum from schizophrenic patients, in contrast to that from normal individuals and non-schizophrenic patients, when applied topically to the rat cerebral cortex, increased the amplitude of potentials evoked in the somato-sensory area by stimulation of the contralateral forepaw. Furthermore, similar changes were found when urine extracts were tested in the same manner (German and Kemali, 1963; Kemali, 1964).

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

British Medical Journal (1963). “Blurred signposts in schizophrenia.” i, 695696.Google Scholar
German, G. A. (1961). “Serum from schizophrenics and cortical potentials in the rat.” J. Physiol., 160, 1011 P.Google Scholar
German, G. A. (1963). “Effects of serum from schizophrenics on evoked cortical potentials in the rat.” Brit. J. Psychiat., 109, 616623.Google Scholar
German, G. A. and Kemali, D. (1963). “Effect of extracts from the urine of schizophrenic patients on the evoked cortical response in the rat.” Mature (Lond.), 198, 791792.CrossRefGoogle Scholar
Kemali, D. (1964). “The effect of urinary fractions from schizophrenic patients on the electrical activity of the brain.” Brit. J. Psychiat. 110, 576581.Google Scholar
Parkes, C. M. (1963). “Interhospital and intrahospital variations in the diagnosis and severity of schizophrenia.” Brit. J. Prev. Soc. Med., 17, 8589.Google Scholar
Price, H. L. (1960). “A dynamic concept of the distribution of thiopental in the human body.” Anaesthesiology, 21, 4045.Google Scholar
Timbury, G. C., and Mowbray, R. M. (1964). “The diagnosis of schizophrenia by Scottish psychiatrists.” Brit. J. Psychiat., 110, 174180.CrossRefGoogle Scholar
Wingo, J. K. (1961). “A simple and reliable subclassification of chronic schizophrenia.” J. Ment. Sci., 107, 862875.CrossRefGoogle Scholar
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