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Efficacy of Antianxiety Drug Therapy in Alcohol Post-Intoxication Symptoms

A Double-Blind Study of Chlorprothixen, Oxazepam and Placebo

Published online by Cambridge University Press:  29 January 2018

Åke Bliding
Åke Bliding*
Affiliation:
Department of Psychiatry II, University of Lund, St. Lars Sjukhus, Lund, Sweden, S 220 06
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Extract

The frequency and intensity of various alcohol post-intoxication symptoms and their regression was studied during a three week double-blind treatment period. During the first two weeks daily doses of 60–120 mg. chlorprothixen and 120–240 mg. oxazepam respectively were given. During the third week a dose reduction was generally made, and during the fourth week placebo treatment was given. As an alternative treatment placebo alone was given during four weeks. No other medication than the coded substance was allowed during the observation period. The dose-response technique was used for ethical and practical reasons. The results have been registered by means of psychometric tests as well as assessments made by the patients, the personnel and the psychiatrist (the author) (Fig.). Some of these results have already been accounted for (Bliding, 1970) and will consequently not be mentioned here.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 122 , Issue 569 , April 1973 , pp. 465 - 467
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Bliding, Å. (1970). ‘Psykofarmakabehandling av alkohol-betingade postintoxikationstillstånd.’ Nordisk Psykiatrisk Tidskrift, 24, 299–309.Google Scholar
Izikowitz, S. (1958). ‘Psychiatric sequelae of alcoholic excess.’ Nordisk Medicin, 60, 1009–15.Google Scholar
Kaij, L. (1960). Alcoholism in Twins. Lund.Google Scholar
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