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Published online by Cambridge University Press: 29 January 2018
For genetic characteristics controlled by a single locus which are such that the degree of dominance is not dependent on the environment, statistical methods of determining the mode of inheritance and the gene frequencies are now well understood in principle. If, however, there is incomplete penetrance, depending on the environment (taken in the wide sense), the problem becomes much more difficult, especially in human genetics. The situation is even worse if the character is dependent on several or many loci and such characteristics are often very dependent on environmental factors. This seems to occur in man in some psychiatric diseases and is certainly the case for intelligence. The genetical analysis of such phenomena is very difficult, and it is essential that the mathematical and statistical bases of such investigations be carefully understood by anyone who undertakes such work.
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