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Failure to Replicate Evoked Potential Observations Suggesting Corpus Callosum Dysfunction in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Charles Shagass ,
Richard C. Josiassen ,
Richard A. Roemer ,
John J. Straumanis  and
Stephen M. Slepner
Charles Shagass
Affiliation:
Temple University Medical School and Eastern Pennsylvania Psychiatric Institute, Philadelphia PA 19129, U.S.A.
Richard C. Josiassen
Affiliation:
Temple University Medical School and Eastern Pennsylvania Psychiatric Institute, Philadelphia PA 19129, U.S.A.
Richard A. Roemer
Affiliation:
Temple University Medical School and Eastern Pennsylvania Psychiatric Institute, Philadelphia PA 19129, U.S.A.
John J. Straumanis
Affiliation:
Temple University Medical School and Eastern Pennsylvania Psychiatric Institute, Philadelphia PA 19129, U.S.A.
Stephen M. Slepner
Affiliation:
Temple University Medical School and Eastern Pennsylvania Psychiatric Institute, Philadelphia PA 19129, U.S.A.
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Summary

Somatosensory potentials (SEPs) evoked by vibrotactile finger stimulation have been reported to be the same in both hemispheres in schizophrenics, whereas they are asymmetrical in normals, with the contralateral hemisphere leading the ipsilateral (Jones and Miller, 1981). These findings were taken to indicate that the corpus callosum is nonfunctional in schizophrenics. To attempt replication of these results, vibrotactile SEPs of 6 schizophrenics and 6 normal controls were recorded with both bipolar and monopolar derivations. Assymetrical bipolar SEPs were obtained in both schizophrenics and controls; previous observations of schizophrenic-control differences were not replicated. Acceptable evidence of ipsilateral early SEPs was not obtained; the test procedure seems inappropriate for measuring callosal conduction time.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 142 , Issue 5 , May 1983 , pp. 471 - 476
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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