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Functional Anatomy of Obsessive–Compulsive Phenomena

Published online by Cambridge University Press:  02 January 2018

P. K. McGuire ,
C. J. Bench ,
C. D. Frith ,
I. M. Marks ,
R. S. J. Frackowiak  and
R. J. Dolan
P. K. McGuire*
Affiliation:
Institute of Psychiatry and MRC Cyclotron Unit, London
C. J. Bench
Affiliation:
MRC Cyclotron Unit, London
C. D. Frith
Affiliation:
MRC Cyclotron Unit, London
I. M. Marks
Affiliation:
Institute of Psychiatry, London
R. S. J. Frackowiak
Affiliation:
MRC Cyclotron Unit, London
R. J. Dolan
Affiliation:
The National Hospital, and Royal Free Hospital School of Medicine, London
*
∗Institute of Psychiatry, De Crespigny Park, London SES 8AF
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Abstract

Regional cerebral blood flow was measured with H215O positron emission tomography in four patients with obsessive–compulsive disorder. Patients were scanned on 12 occasions in the same session, with each scan paired with brief exposure to one of a hierarchy of contaminants that elicited increasingly intense urges to ritualise. The relationship between symptom intensity and regional cerebral blood flow (rCBF; an index of neural activity) was subsequently examined in the group and in individual patients. The group showed significant positive correlations between symptom intensity and blood flow in the right inferior frontal gyrus, caudate nucleus, putamen, globus pallidus and thalamus, and the left hippocampus and posterior cingulate gyrus. Negative correlations were evident in the right superior prefrontal cortex, and the temporoparietal junction, particularly on the right side. The pattern in single subjects was broadly similar, although individual differences in neural response were also observed. A graded relationship between symptom intensity and regional brain activity can thus be identified in obsessive–compulsive disorder. It is hypothesised that the increases in rCBF in the orbitofrontal cortex, neostriatum, global pallidus and thalamus were related to urges to perform compulsive movements, while those in the hippocampus and posterior cingulate cortex corresponded to the anxiety that accompanied them.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 4 , April 1994 , pp. 459 - 468
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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