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A Genetic Model Compatible with a Dimensional View of Schizophrenia

Published online by Cambridge University Press:  03 January 2018

David Roberts  and
Gordon Claridge
David Roberts*
Affiliation:
Genetics Laboratory, Department of Biochemistry, Oxford University
Gordon Claridge
Affiliation:
Department of Experimental Psychology, Oxford University
*
∗Genetics Laboratory, Department of Biochemistry, South Parks Road, Oxford OX1 3QU
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Extract

Throughout the history of schizophrenia as a psychiatric concept, opinions have differed sharply over its essential nature and its causes, giving rise to a wide range of explanations that have drawn upon ideas from almost all of the social and biological sciences. Only one fact has truly survived the vicissitudes of argument about the condition: that genetic factors contribute to its aetiology. Even that conclusion, first reached in the very early days of schizophrenia research, sank temporarily out of sight during the radical psychiatry challenges of the 1960s. However, the continuing collection of family, twin, adoption and other data over that period put the genetic hypothesis beyond reasonable doubt (McGuffin, 1988).

Type
Annotation
Information
The British Journal of Psychiatry , Volume 158 , Issue 4 , April 1991 , pp. 451 - 456
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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References

Akam, M. E. (1987) The molecular basis for metameric pattern in the Drosophila embryo. Development, 101, 1–22.Google Scholar
Anderson, K. V. (1987) Dorsal-ventral embryonic pattern genes of Drosophila . Trends in Genetics, 3, 91–97.Google Scholar
Beadle, G. W. & Ephrussi, B. (1937) Development of eye colours in Drosophila: diffusable substances and their interrelations. Genetics, 22, 76–86.Google Scholar
Claridge, G. (1987) “The schizophrenias as nervous types” revisited. British Journal of Psychiatry, 151, 735–743.Google Scholar
Claridge, G. (1988) Schizotypy and schizophrenia. In Schizophrenia. The Major Issues (eds P. Bebbington & P. McGuffin). Oxford: Heinemann.Google Scholar
Crow, T. J. (1987) Recurrent and Chronic Psychoses. Edinburgh: Churchill Livingstone.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1976) Psychoticism as a Dimension of Personality. London: Hodder and Stoughton.Google Scholar
Gottesman, I. I. & Shields, J. (1982) Schizophrenia. The Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Gottesman, I. I., McGuffin, P. & Farmer, A. E. (1987) Clinical genetics as clues to the ‘real’ genetics of schizophrenia. Schizophrenia Bulletin, 13, 23–47.Google Scholar
Kennedy, J. L., Giuffra, L. A., Moises, H. W., et al (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature, 336, 167–170.Google Scholar
McGuffin, P. (1988) Genetics of schizophrenia. In Schizophrenia. The Major Issues (eds P. Bebbington & P. McGuffin). Oxford: Heinemann.Google Scholar
Meehl, P. E. (1962) Schizotaxia, schizotypy, schizophrenia. American Psychologist, 17, 827–838.Google Scholar
Nöthiger, R. & Steinmann-Zwicky, M. (1985) Sex determination in Drosophila . Trends in Genetics, 1, 209–214.Google Scholar
Pato, C. N., Lander, E. S. & Schulz, S. C. (1989) Prospects for the genetic analysis of schizophrenia. Schizophrenia Bulletin, 15, 365–372.Google Scholar
Ratnoff, O. D. (1978) Hereditary disorders of hemostasis. In The Metabolic Basis of Inherited Disease (4th edn) (eds J. B. Stanbury, J. B. Wyngaarden & D. S. Fredrickson). New York: McGraw-Hill.Google Scholar
Roberts, D. B., Blackwell, S. A. & Loughlin, S. A. R. (1984) Quantitative analysis of the amount of larval serum (protein-1 (LSP-1) synthesized by flies with different doses of the LSP-1 coding sequences. Biochemical Genetics, 22, 783–795.Google Scholar
Sherrington, R., Brynjolfsson, J., Petursson, H., et al (1988) Localisation of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164–167.Google Scholar
Summers, K. M., Howells, A. J. & Pyliotis, N. A. (1982) Biology of eye pigmentation in insects. Advances in Insect Physiology, 16, 119–166.Google Scholar
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