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Heterogeneity of Schizophrenia

Conceptual Models and Analytic Strategies

Published online by Cambridge University Press:  02 January 2018

Ming T. Tsuang ,
Michael J. Lyons  and
Stephen V. Faraone
Ming T. Tsuang*
Affiliation:
Section of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center; Harvard Program in Psychiatric Epidemiology; Psychiatry Service, Brockton/West Roxbury Veterans Administration Medical Center
Michael J. Lyons
Affiliation:
Department of Psychology, Boston University; Section of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center; Psychiatry Service, Brockton/West Roxbury Veterans Administration Medical Center
Stephen V. Faraone
Affiliation:
Section of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center; Psychiatry Service, Brockton/West Roxbury Veterans Administration Medical Center
*
∗Brockton/West Roxbury Veterans Administration Medical Center, 940 Belmont Street, Brockton, Massachusetts, 02401, USA
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Abstract

Schizophrenia is clinically heterogeneous but it is not known whether this is due to the existence of discrete subtypes. For the purpose of explication, ‘indicators' of schizophrenia are divided into three levels: phenomenology, pathophysiology, and aetiology. Five heterogeneity models and a number of quantitative approaches are described. It is imperative to apply rigorous methods of study to the comparison of unitary models and competing heterogeneity models of schizophrenia.

Type
Lecture
Information
The British Journal of Psychiatry , Volume 156 , Issue 1 , January 1990 , pp. 17 - 26
Copyright
Copyright © The Royal College of Psychiatrists 

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Footnotes

∗

This paper was presented, in part, as the Maudsley Hospital Bequest Lecture at the Royal College of Psychiatrists' Winter Quarterly Meeting on 27 January 1988 in London by Dr Ming T. Tsuang.

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