Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-28T02:50:34.943Z Has data issue: false hasContentIssue false

The Impact of Lithium in South-West Scotland I. Demographic and Clinical Findings

Published online by Cambridge University Press:  29 January 2018

Summary

A point-prevalence study in South-west Scotland found that 0.77 per 1,000 of the total population were receiving lithium. Almost one quarter had done so for more than ten years. At the time of lithium commencement, only 68% had always been diagnosed as having an affective illness; 59% of the patients were also receiving antidepressants, major tranquillisers, or both. Though this might be due in part to unnecessary administration of supplementary drugs, 19% of non-inpatients had moderate depressive symptoms, significant depressive illness, or manic symptoms. Lithium side-effects were prominent: 30% of the sample complained of weight gain, thirst or excessive micturition; 42% had noticed hair changes; and 7% had diminished thyroid activity, but most patients believed they had benefited considerably from lithium therapy.

Type
Research Article
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abou-Saleh, M. T. & Coppen, A. (1983) Subjective side effects of amitriptyline and lithium in affective disorders. British Journal of Psychiatry, 142, 391–7.Google Scholar
Angst, J., Weis, P., Grof, P., Baastrup, P. C. & Schou, M. (1970) Lithium prophylaxis in recurrent affective disorders. British Journal of Psychiatry, 116, 604–14.Google Scholar
Anonymous (1979) Lithium and the kidney; grounds for cautious optimism. Lancet, 2, 1056–7.Google Scholar
Baastrup, P. C. (1980) Lithium in the prophylactic treatment of recurrent affective disorders. In: Handbook of Lithium Therapy (ed. Johnson, F. N.). Lancaster: MTP Press.Google Scholar
Bucht, G., Von Knorring, L., Smigan, L. & Wahlin, A. (1981) Control of lithium treatment—experiences from a lithium clinic. Nordisk Psychiatrisk Tiddskrift, 160–5.Google Scholar
Cade, J. F. J. (1949) Lithium salts in the treatment of psychotic excitement Medical Journal of Australia, 2, 349–52.Google Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H. Swani, M. S., Hare, E. H. et al (1971) Prophylatic lithium in affective disorders: controlled trial. Lancet, 2, 275–9.Google Scholar
Dawber, R. & Mortimer, P. (1982) Hair loss during lithium treatment. British Journal of Dermatology, 105, 124–5.Google Scholar
Fieve, R. R., Dunner, D. L., Kumbaraci, T. & Stallone, F. (1975) Lithium carbonate in affective disorders. IV. A double-blind study of prophylaxis in unipolar recurrent depression. Archives of General Psychiatry, 32, 1541–44.Google Scholar
General Registrar Office, Scotland (1981) Census, 1981. Scotland: Preliminary Report. Edinburgh: HMSO.Google Scholar
Ghose, K. (1977) Lithium: therapeutic and unwanted effects. British Journal of Hospital Medicine, 18, 578–83.Google ScholarPubMed
Glen, A. I. M. (1978) Lithium regulation of membrane ATPases. In: Lithium in Medical Practice (eds Johnson, F. N. and Johnson, S.). Lancaster: MTP Press.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.Google Scholar
HMSO (1980) Classification of Occupations. London: Office of Population Censuses and Surveys, HMSO.Google Scholar
Hullin, R. P. (1978) The place of lithium in biological psychiatry. In: Lithium in Medical Practice (eds Johnson, F. N. and Johnson, S.). Lancaster: MTP Press.Google Scholar
McCreadie, R. G., McCormick, M. & Morrison, D. P. (1984) The impact of lithium in south-west Scotland. III. The discontinuation of lithium. British Journal of Psychiatry, in press.Google Scholar
Morrison, D. P. & McCreadie, R. G. (1984) The impact of lithium in south-west Scotland. II. A longitudinal study. British Journal of Psychiatry. In press.Google Scholar
Sashidharan, S. P. & McGuire, R. J. (1983) Recurrence of affective illness after withdrawal of long-term lithium treatment. Acta Psychiatrica Scandinavica, 68, 126–33.Google Scholar
Schou, M. (1980) The range of non-psychiatric uses of lithium. In: Handbook of Lithium Therapy (ed. Johnson, F. N.). Lancaster: MTP Press.Google Scholar
Shaw, D. M. (1980) The context of lithium therapy. In: Handbook of Lithium Therapy (ed. Johnson, F. N.). Lancaster: MTP Press.Google Scholar
Siegel, S. (1956) Non-parametric Statistics for the Behavioural Sciences. New York: McGraw Hill.Google Scholar
Stallone, F., Shelle, E. & Mendlewitz, J. (1973) The use of lithium in affective disorders. III. A double-blind study of prophylaxis in bipolar illness. American Journal of Psychiatry, 130, 1006–10.Google Scholar
World Health Organisation (1974) Glossary of Mental Disorders and Guide to their Classifications for use in conjunction with the International Classification of Diseases. Eighth Revision. Geneva: WHO.Google Scholar
World Health Organisation (1978) Mental Disorders: Glossary and guide to their Classification in accordance with the Ninth Revision of the International Classification of Diseases. Geneva: WHO.Google Scholar
Young, R. C., Biggs, J. T., Ziegler, V. E. & Meyer, D. A. (1978) A rating scale for mania: reliability, validity, and sensitivity. British Journal of Psychiatry, 133, 429–35.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.