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Lipids and schizophrenia

Published online by Cambridge University Press:  02 January 2018

Nicholas P. Walker ,
Helen C. Fox  and
Lawrence J. Whalley
Nicholas P. Walker
Affiliation:
University of Aberdeen Medical School, Royal Cornhill Hospital, Aberdeen
Helen C. Fox
Affiliation:
University of Aberdeen Medical School, Royal Cornhill Hospital, Aberdeen
Lawrence J. Whalley*
Affiliation:
University of Aberdeen Medical School, Royal Cornhill Hospital, Aberdeen
*
Professor Lawrence J. Whalley. University of Aberdeen Medical School, Royat Cornhill Hospital, Aberdeen AB25 2ZH. e-mail: mental.health.CRC@abdn.ac.uk
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Abstract

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Type
Editorials
Information
The British Journal of Psychiatry , Volume 174 , Issue 2 , February 1999 , pp. 101 - 104
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

References

Abdulla, Y. H. & Hamadah, K. (1975) Effect of ADP on PGE, formation in blood platelets from patients with depression, mania and schizophrenia. British Journal of Psychiatry, 127, 591–595.CrossRefGoogle Scholar
Albers, M., Meurer, H., Marid, F., et al (1993) Phospholipase A2 activity in serum of neuroleptic naive psychiatric inpatients. Pharmacopsychiatry, 26, 94–98.CrossRefGoogle ScholarPubMed
Brawn, A. J., Pang, E. & Roberts, D. C. K. (1991) Persistent changes in the fatly acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids study design implications. American Journal of Clinical Nutrition, 54, 668–671.Google Scholar
Carlson, S. E., Carver, J. D., & House, S. G. (1986) High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linolenic acid: a comparison of rat neural and red cell membrane phospholipids. Journal of Nutrition, 116, 718–725.CrossRefGoogle ScholarPubMed
Crawford, M. A. (1993) The role of essential fatty acids in neural development, implications for perinatal nutrition. American Journal of Clinical Nutrition, 57 (suppl.): 703–710.CrossRefGoogle ScholarPubMed
Duthie, S. J., Ma, A., Ross, M. A., et al (1996) Antioxidant supplementation decreased oxidative DNA damage in human lymphocytes. Cancer Research, 56, 1291–1295.Google Scholar
Fischer, S., Kissling, W. & Kuss, H. J. (1992) Schizophrenic patients treated with high dose phenothiazine or thiocanthene become deficient in polyunsaturated fatty acids in their thrombocytes. Biochemical Pharmacology, 44, 317–323.CrossRefGoogle ScholarPubMed
Gattaz, W. F., Kollisch, M., Thuren, T., et al (1987) Increased plasma phospholipase a2 activity in schizophrenic patients: reduction after neuroleptic therapy. Biological Psychiatry, 22, 421–426.Google Scholar
Glen, A. I., Glen, E. M., Horrobin, D. F., et al (1994) A red cell membrane abnormality in a subgroup of schizophrenic patients evidence for two diseases. Schizophrenia Research, 12, 53–61.CrossRefGoogle Scholar
Hess, D. T., Patterson, S. I., Smith, D. S., et al (1993) Neuronal growth cone collapse and inhibition of protein fatly acylation by nitric oxide. Nature, 344, 562–565.Google Scholar
Horrobin, D. F. (1977) Schizophrenia as a prostaglandin deficiency disease, Loncet, 1, 936–937.CrossRefGoogle ScholarPubMed
Horrobin, D. F., Minku, M. S., Hillman, H., et al (1991) Fatty acid levels in the brains of schizophrenics and normal controls. Biological Psychiatry, 30, 795–805.CrossRefGoogle ScholarPubMed
Hudson, C. J., Kennedy, J. L., Gotowiec, A., et al (1996) Genetic variant near cytosolic phospholipase a2 associated with schizophrenia. Schizophrenia Research, 21, 111–116.CrossRefGoogle ScholarPubMed
Huttenlocher, F. (1979) Synaptic density in human frontal cortex, developmental changes and effects of ageing. Brain Research, 163, 195–205.Google Scholar
Jones, P. & Murray, R. M. (1991) The genetics of schizophrenia is the genetics of neurodevelopment. British Journal of Psychiatry, 158 615–623.Google Scholar
Lucas, A., Morley, R. Cole, T. J., et al (1991) Breast milk and subsequent intelligence quotient in children born preterm. Loncet, 339, 261–264.Google Scholar
Makrides, M., Naumann, M. A., Byard, R. W., et al (1994) Fatty acid composition of brain, retina and erythrocytes in breast- and formula-fed infants. American Journal of Clinical Nutrition, 60, 189–194.CrossRefGoogle ScholarPubMed
McCreadia, R. G., Macdonald, E., Wiles, D., et al (1995) The Nithsdale schizophrenia surveys, XIV: Plasma lipid peroxide and serum vitamin E levels in patients with and without tardive dyskinesia and in normal subjects. British Journal of Psychiatry, 167, 610–617.Google Scholar
McGill, H. C., Mott, G. E., Lewis, D. S., et al (1996) Early determinants of adult regulation, effects of infant nutrition on adult lipid and lipoprotein metabolism. Nutrition Reviews, 54 (suppl.): 31–40.Google Scholar
Mellor, J. E., Laugharne, J. D. E. & Peet, M. (1996) Omega, 3 fatty acid supplementation in schizophrenic patients. Human Psychopharmacology, 11, 39–46.Google Scholar
Moser, H. W. (1993) Lorenzo oil therapy for adrenoleukodystrophy: a prematurely amplified hope. Annals of Neurology, 34, 121–122.CrossRefGoogle ScholarPubMed
Negre-Aminou, P., Nemenoff, R. A., Wood, M. R., et al (1996) Characterization of phospholipase A2 activity enriched in the nerve growth done. Journal of Neurochemistry, 67, 2599–2608.Google Scholar
Peet, M., Laugharne, J. D., Horrobin, D. F., et al (1994) Arachidonic acid a common link in the biology of schizophrenia? [Letter]. Archives of General Psychiatry, 51, 665–666.Google Scholar
Pettegrew, J. W. Keshavan, M. S., Panchalingam, K., et al (1991) Alterations in bram high-energy phosphate and membrane phospholipid metabolism in first-eprsode, drug-naive schizophrenics A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Archives of General Psychiatry, 48, 563–568.Google Scholar
Price, S., Fox, H., St Clair, D., et al (1997) Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene. Psychiatric Genetics, 7, 111–114.Google Scholar
Puri, B. K., Steiner, R. & Richardson, A. J. (1998) Sustained remission of positive and negative symptoms of schizophrenia following treatment with eicosapentaenoic acid. Archives of General Psychiatry, 55, 188–189.Google Scholar
Ross, B. M., Hudson, C., Erlich, J., et al (1997) Increased phospholipid breakdown in schizophrenia, evidence for the involvement of a calcium independent phospholipase A2. Archives of General Psychiatry, 54, 487–494.Google Scholar
Smalheiser, N. R., Dissanayake, S. & Kapil, A. (1996) Rapid regulation of neunte outgrowth and retraction by phospbolipase A2-dcrived arachidonic acid and its metaboites. Brain Research, 721, 39–48.CrossRefGoogle Scholar
Stanley, J. A., Williarnson, P. C., Drost, D. J., et al (1995) An in vivo study of the prefrontal cortex of schizophrenic patients al different stages of ilness via phosphorus magnetic resonance spectroscopy. Archives of General Psychiatry, 52, 399–406.CrossRefGoogle Scholar
Whalley, L. J., Christie, J. E., Blackwood, D. H. R., et al (1989) Disturbed endocrine function in the psychoses, disordered homeostasis or disease process. British Journal of Psychiatry, 155, 455–461.Google Scholar
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