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Mania and Down's Syndrome

Published online by Cambridge University Press:  02 January 2018

Sally-Ann Cooper  and
Richard A. Collacott
Sally-Ann Cooper*
Affiliation:
Frith Hospital, Groby Road, Leicester LE3 9QF
Richard A. Collacott
Affiliation:
Frith Hospital, Leicester
*
∗Correspondence
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Abstract

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 162 , Issue 6 , June 1993 , pp. 739 - 743
Copyright
Copyright © The Royal College of Psychiatrists 

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