Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-10T08:04:43.245Z Has data issue: false hasContentIssue false
  • English
  • Français

Meissner Corpuscles in Skin Biopsies of Patients with Presenile Dementia: A Quantitative Study

Published online by Cambridge University Press:  29 January 2018

Richard Hunter ,
Alan Ridley  and
Andrew Malleson
Richard Hunter
Affiliation:
The National Hospital, Queen Square, W.C.1; Friern and Whittington Hospitals, London
Alan Ridley
Affiliation:
M.R.C. Research Group in Applied Neurobiology, Institute of Neurology, Queen Square, W.C.1
Andrew Malleson
Affiliation:
Friern Hospital, London
Get access Rights & Permissions [Opens in a new window]

Extract

Neuropathological study of the group of presenile dementias, whether apparendy primarily a degeneration of cortical neurones or secondary to vascular, inflammatory or other disease, has for obvious reasons centered on the brain. However, it is possible that the degenerative process may in certain types also affect the peripheral nervous system. If this were so it would be valuable to recognize it not only from the pathological point of view but also, since peripheral nerves are more easily investigated during life, for differential diagnosis which is often difficult and sometimes impossible on clinical findings alone. While involvement of the lower motor neurone is unlikely to be present without causing physical signs impairment of sensation due to involvement of the primary sensory neurone may be overlooked, more especially because sensory testing is often not possible in demented patients.

Type
Shorter Papers
Information
The British Journal of Psychiatry , Volume 115 , Issue 520 , March 1969 , pp. 347 - 349
Copyright
Copyright © Royal College of Psychiatrists, 1969 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bolton, C. F., Winkelmann, R. K., and Dyck, P. J. (1966). “A quantitative study of Meissner's corpuscles in man.” Neurology (Minneapolis), 16, 1–9.CrossRefGoogle Scholar
Cavanagh, J. B. (1964). “The significance of the ‘dying-back’ process in experimental and human neurological disease.” Int. Rev. exp. Path., 3, 219–267.Google Scholar
Dickens, W. N., Winkelmann, R. K., and Mulder, D. W. (1963). “Cholinesterase demonstration of dermal nerve endings in patients with impaired sensation.” Neurology (Minneapolis), 13, 91–100.Google Scholar
Ridley, A. (1968). “Silver staining of the innervation of Meissner corpuscles in peripheral neuropathy.” Brain, 91, 539–552.Google Scholar
Ridley, A. (1969). “Silver staining of nerve endings in human digital glabrous skin.” J. Anat., 104, 44–48.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.