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Neuroendocrine Challenges in the Diagnosis of Depressive Disorders

Published online by Cambridge University Press:  06 August 2018

J. J. López-Ibor Jr ,
J. Saiz-Ruiz  and
L. Moral Iglesias
J. J. López-Ibor Jr
Affiliation:
University of Alcalá de Henares, Spain
J. Saiz-Ruiz
Affiliation:
Psychiatric Teaching Unit, University of Alcalá de Henares, Madrid, Spain
L. Moral Iglesias
Affiliation:
Psychiatric Teaching Unit, University of Alcalá de Henares, Madrid, Spain
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Extract

An important topic in the neurobiology of the affective disorders relates to changes in the metabolism of neurotransmitters. Since the early 1960s, the ‘serotonergic’ hypothesis (Coppen et al, 1972) has been supported by findings such as a low concentration of 5-hydroxy-indoleacetic acid (5-HIAA) in the cerebro-spinal fluid (CSF) of patients with melancholic depression and/or suicidal behaviour (Banki & Arato, 1983; Åsberg et al, 1984; Banki et al, 1984; López-Ibor, Jr et al, 1985; Korpi et al, 1986) as well as the efficacy of serotonin precursors, when combined with MAOIs, in the treatment of depressed patients (Coppen et al, 1963; Glassman & Platman, 1969; Ayuso et al, 1971; López-Ibor, Jr et al, 1976).

Type
II. Biological Aspects
Information
The British Journal of Psychiatry , Volume 154 , Issue S4: Psychiatric Diagnosis: Nosological, Biological and Psychological Aspects , May 1989 , pp. 73 - 76
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Åsberg, M., Edman, G., Rydin, E., et al (1984) Biological correlates of suicidal behaviour. Clinical Neuropharmacology, 7, 758–759.CrossRefGoogle Scholar
Ayuso Gutterrez, J. L. & López-Ibor Alino, J. J. (1971) Tryptophan and M.A.O.I. (nialamide) in the treatment of depression. International Pharmacopsychiatry, 6, 92–97.CrossRefGoogle Scholar
Banki, C. M. & Arato, M. (1983) Amine metabolites and neuroendocrine responses related to depressions and suicide. Journal of Affective Disorders, 5, 223–232.CrossRefGoogle ScholarPubMed
Banki, C. M., Arato, M., Papp, Z., et al (1984) Biochemical markers in suicide patients. Journal of Affective Disorders, 6, 345–350.Google Scholar
Brewerton, T., Mueller, E., George, T., et al (1986) Blunted prlactin response to the serotonin agonist m-Chlorophenylpiperazine (m-CPP) in Bulimia. San Juan, Puerto Rico. Paper presented at the 15th Congress of the CINP.Google Scholar
Bulat, M. (1984) Some criteria for the study of biochemical processes in CNS by analysis of cerebrospinal fluid (CSF). Clinical Neuropharmacology, 7 (Suppl. 1), 286–287.CrossRefGoogle Scholar
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of E.C.T. response. British Journal of Psychiatry, 111, 659–674.CrossRefGoogle ScholarPubMed
Coppen, A., Shaw, D. M. & Farrell, J. D. (1963) Potentiation of antidepressive effect of monoamine oxidase inhibitor by tryptophan. Lancet, i, 79–81.CrossRefGoogle Scholar
Coppen, A., Prange, A. J., Whybrow, P. C., et al (1972) Abnormalities of indoleamines in affective disorders. Archives of General Psychiatry, 26, 474–478.CrossRefGoogle ScholarPubMed
Demisch, K., Demisch, L., Buchholz, G., et al (1985) Effect of Pirlindole on endocrine parameters in healthy man. In Psychiatry. The State of the Art Vol. 3 (eds P. Pichot, P. Berner, R. Wolf et al) pp. 219–232. New York: Plenum.CrossRefGoogle Scholar
Garattini, S., Caccia, S., Mennini, T., et al (1979) Biochemical pharmacology of the anorectic drug fenfluramine: a review. Current Medical Research Operation, 6 (Suppl), 15–27.CrossRefGoogle Scholar
Glassman, A. & Platman, S. R. (1969) Potentiation of a monoamine oxidase inhibitor by tryptophan. Journal of Psychiatric Research, 7, 83–88.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology and Neurosurgery Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Heninger, G. R., Charney, D. S. & Sternberg, D. E. (1984) Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and health subjects. Archives of General Psychiatry, 41, 398–402.CrossRefGoogle Scholar
Holsboer, F., Muller, O. A., Winter, K., et al (1983) Effect of serotonin uptake inhibition by Zimelidine on hypothalamicpituitary-adrenal activity. Psychopharmacology, 880, 85–87.CrossRefGoogle Scholar
Korpi, E. S., Kleinman, J. E., Goodman, S. I., et al (1986) Serotonin and 5-Hydroxyindoleacetic acid in brains of suicide victims. Archives of General Psychiatry, 43, 594–600.CrossRefGoogle ScholarPubMed
Koyama, T. & Meltzer, H. Y. (1986) A biochemical and neuroendocrine study of the serotonergic system in depression. In New Results in Depression Research (ed. Hippius, H. et al) pp. 169–188. Berlin: Springer.CrossRefGoogle Scholar
Laakmann, G., Gugath, M., Kuss, H. T., et al (1984) Comparison of growth hormone and prolactin stimulation induced by clomipramine and desipramine in man in connection with clomipramine metabolism. Psychopharmacology, 82, 62–67.CrossRefGoogle Scholar
López-Ibor, J. J. Jr (translator) (1980) El Sistema A.M.D.P. (Asociacion para la metodologia y documentacion en Psiquiatria) Garsi, Madrid.Google Scholar
López-Ibor, J. J. Jr, Ayuso Gutierrez, J. L. & Montejo Iglesias, L. (1976) 5-Hydroxytryptophan (5-OHTp) and MAOI (Nialimide) in the treatment of depression. International Pharmacopsychiatry, 11, 8–15.CrossRefGoogle Scholar
López-Ibor, J. J. Jr, Saiz Ruiz, J. & Perez De Los Cobos, J. C. (1985) Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxi-indoleacetic acid and cortisol in cerebral spinal fluid, Dexamethasone suppression test and therapeutic response to 5-Hydroxytryptophan. Neuropsychobiology, 14, 67–74.CrossRefGoogle ScholarPubMed
Meltzer, H. Y., Umberkoman-Wita, B., Robertson, A., et al (1984) Effect of 5-Hydroxtryptophan on serum Cortisol levels in major affective disorders. I: Enhanced response in depression and mania. Archives of General Psychiatry, 41, 366–374.CrossRefGoogle Scholar
Parati, E. A., Zanardi, E., Cocchi, D., et al (1987) Neuroendocrine effects of quipazine in man in healthy state or with neurological disorders. Journal of Neurology Transmission, 47, 273–297.CrossRefGoogle Scholar
Quattrone, A., Di Renzo, G., Schettini, G., et al (1978) Increased plasma prolactin levels induced in rats by d-Fenfluramine: Relation to central serotonergic stimulation. European Journal of Pharmacology, 49, 163–167.CrossRefGoogle ScholarPubMed
Siever, L. J., Murphy, D. L., Slater, S., et al (1984) Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Science, 34, 1029–1039.CrossRefGoogle ScholarPubMed
Spitzer, R. L. & Williams, J. B. W. (1985) Structured clinical interview for DSM-III-R - patient version (SCID-P), New York.Google Scholar
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