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No evidence for left superior temporal dysfunction in asymptomatic schizophrenia and bipolar disorder

PET study of verbal fluency

Published online by Cambridge University Press:  03 January 2018

Stephen Dye ,
Sean Spence ,
Christopher Bench ,
Steven Hirsch ,
Martin Stefan ,
Tonmoy Sharma  and
Paul Grasby
Stephen Dye*
Affiliation:
Psychological Medicine, Imperial College School of Medicine, Department of Psychiatry, Charing Cross Hospital, London
Sean Spence
Affiliation:
Psychological Medicine, Imperial College School of Medicine, Department of Psychiatry, Charing Cross Hospital, London
Christopher Bench
Affiliation:
Psychological Medicine, Imperial College School of Medicine, Department of Psychiatry, Charing Cross Hospital, London
Steven Hirsch
Affiliation:
Psychological Medicine, Imperial College School of Medicine, Department of Psychiatry, Charing Cross Hospital, London
Martin Stefan
Affiliation:
Fulbourn Hospital, Cambridge
Tonmoy Sharma
Affiliation:
Section of Cognitive Psychopharmacology, Institute of Psychiatry, De Crespigny Park, London
Paul Grasby
Affiliation:
MRC Cyclotron Unit, Division of Neuroscience and Hammersmith Hospital, London
*
Dr Stephen Dye, Department of Psychiatry, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Rd, London W6 8RF. E-mail: s.dye@ic.ac.uk
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Abstract

Background

Positron emission tomography (PET) studies have revealed functional left superior temporal gyrus (STG) abnormalities in symptomatic schizophrenia during word generation.

Aims

To discover if this dysfunction is present in asymptomatic schizophrenia. To determine whether, without concurrent symptomatology, schizophrenia and bipolar affective disorder (BPD) are distinguishable by differing regional cerebral blood flow (rCBF) patterns during word generation.

Method

A PETverbal fluency protocol was applied to six patients with BPD in remission and six patients with asymptomatic schizophrenia. Analysis included 10 control subjects from a contemporaneous study.

Results

All groups showed relative reduction of rCBF in both superior temporal cortices. There were no quantitative differences in any group comparison. All groups exhibited negative covariation between rCBF in left prefrontal and right (but not left) temporal regions.

Conclusions

Abnormal patterns of left STG function cannot be regarded as a trait marker for schizophrenia. Functional abnormalities may reflect aspects of mental state.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 4 , October 1999 , pp. 367 - 374
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Project funded by the Wellcome Trust.

References

Bench, C. J., Fristion, K. J., Brown, R. G., et al (1993) Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychological Medicine, 23, 579–590.Google Scholar
Cleghorn, J. M., Franco, S., Szechtman, B., et al (1992) Toward a brain map of auditory hallucinations. American Journal of Psychiatry, 149, 1062–1069.Google Scholar
Curtis, V. A., Bullmore, E. T., Brammer, M. J., et al (1998) Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. American Journal of Psychiatry, 155, 1056–1063.Google Scholar
Dolan, R. J., Bench, C. J., Liddle, P. F., et al (1993) Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity? Journal of Neurology, Neurosurgery and Psychiatry, 56, 1290–1294.Google Scholar
Drevets, W. C. (1998) Functional neuroimaging studies of depression: the anatomy of melancholia. Annual Review of Medicine, 49, 341–361.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–844.Google Scholar
Fletcher, P. C., Frith, C. D., Grasby, P. M., et al (1996) Local and distributed effects of apomorphine on frontotemporal function in acute unmedicated schizophrenia. Journal of Neuroscience, 16, 7055–7062.Google Scholar
Fristen, K. J., Passingham, R. E., Nutt, J. G., et al (1989) Localisation in PET images: direct fitting of the intercommisural (AC–PC) line. Journal of Cerebral Blood Flow Metabolism, 9, 690–695.Google Scholar
Fristen, K. J., Frith, C. D., Little, P. F., et al (1993) Functional connectivity: the principal-component analysis of large (PET) data sets. Journal of Cerebral Blood Flow Metabolism, 13, 5–14.Google Scholar
Fristen, K. J., & Frith, C. D., (1995) Schizophrenia: a disconnection syndrome? Clinical Neuroscience, 3, 89–97.Google Scholar
Frith, C. D., Fristen, K. J., Liddle, P. F., et al (1991) A PET study of word finding. Neuropsychologia, 29, 1137–1148.Google Scholar
Frith, C. D., Fristen, K. J., Herold, S., et al (1995) Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British Journal of Psychiatry, 167, 343–349.Google Scholar
Krawiecka, M., Goldberg, D. & Vaughan, M. (1977) A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatrica Scandinavica, 55, 299–308.Google Scholar
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. Briush Journal of Psychiatry, 160, 179–186.CrossRefGoogle ScholarPubMed
McGuire, P. K., Shah, G. M. S. & Murray, R. M. (1993) Increased blood flow in Broca's area during auditory hallucinations in schizophrenia. Lancet, 342, 703–706.Google Scholar
McGuire, P. K. & Frith, C. D. (1996) Disordered functional connectivity in schizophrenia. Psychological Medicine, 26, 663–667.Google Scholar
Nelson, H. E. (1982) The National Adult Reading Test (NART). Windsor: NFER-Nelson.Google Scholar
O'Connell, R. A., Van Heertum, R. L., Luck, D., et al (1995) Single-photon emission computed tomography of the brain in acute mania and schizophrenia. Journal of Neuroimaging, 5, 101–104.Google Scholar
Oldfield, R. C. (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia, 9, 97–113.Google Scholar
Sabri, O, Erkwoh, R., Schreckenberger, M., et al (1997) Correlation of positive symptoms exclusively to hyperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics. Lancet, 349, 1735–1739.Google Scholar
Silbersweig, D. A., Stern, E., Frith, C. D., et al (1993) Detection of thirty-second cognitive activations in single subjects with positron emission tomography: a new low-dose H2 15O regional cerebral blood flow three-dimensional imaging technique. Journal of Cerebral Blood Flow Metabolism, 13, 617–629.Google Scholar
Spence, S. A., Brooks, D. J., Hirsch, S. R., et al (1997) A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control), Brain, 120, 1997–2011.CrossRefGoogle ScholarPubMed
Spence, S. A., Hirsch, S. R., Brooks, D. J., et al (1998) Prefrontal cortex activity in people with schizophrenia and control subjects. Evidence from positron emission tomography for remission of ‘hypofrontality’ with recovery from acute schizophrenia. British Journal of Psychiatry, 172, 316–323.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria for a Selected Group of Functional Disorders. New York: Biometrics Research Division, New York State Psychiatric Institute.Google Scholar
Talairach, J. & Tournoux, P. (1988) A Co-planar Stereotaxic Atlas of a Human Brain. Stuttgart: Thieme.Google Scholar
Woodruff, P. W. R., Wright, I. C., Bullrnore, E. T., et al (1997) Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. American Journal of Psychiatry, 154, 1676–1682.Google Scholar
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