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Positive and Negative Schizophrenic Symptoms and the Role of Dopamine

Published online by Cambridge University Press:  29 January 2018

A. V. P. Mackay*
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge

Abstract

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Type
Discussion
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Andrews, W. M. (1973) Long-acting tranquillisers and the amotivational syndrome in the treatment of schizophrenics. In Community Management of the Schizophrenic in Chemical Remission (ed. E. H. King), 14, Excerpta Medica, Amsterdam.Google Scholar
Bird, E. D., Spokes, E. G. & Iversen, L. L. (1979) Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia. Brain, 102, 347–60.CrossRefGoogle ScholarPubMed
Bleuler, E. (1911) Dementia Praecox or the Group of Schizophrenias. Translated by Zinkin, H., International Universities Press, 1950, New York.Google Scholar
Bowers, M. B. (1974) Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry, 31, 50–4.CrossRefGoogle ScholarPubMed
Chouinard, G. & Jones, B. D. (1978) SchizoSphrenia as dopamine-deficiency disease. Lancet, ii, 99100.CrossRefGoogle Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia; more than one disease process? British Medical Journal, 280, 66–8.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Stevens, M., Kreel, L. & Husband, J. (1978) The dementia of dementia praecox. Acta Psychiatrica Scandinavica, 57, 305–24.CrossRefGoogle ScholarPubMed
Kraepelin, E. (1913) Dementia Praecox and Paraphrenia. Translated by Barclay, R. M. and Robertson, G. M. E. & Livingstone, S. (1919), Edinburgh.Google Scholar
Lee, T., Seeman, P., Rajput, A., Farley, I. J. & Hornykiewicz, O. (1978) Receptor basis for dopaminergic supersensitivity in Parkinson's disease. Nature, 273, 5961.Google ScholarPubMed
Mackay, A. V. P., Bird, E. D., Iversen, L. L., Spokes, E. G., Creese, I. & Snyder, S. H. (1980) Dopaminergic abnormalities in post mortem schizophrenic brain. In Long-Term Effects of Neuroleptics, Advances in Biochemical Psychopharmacology, Vol. 24 (eds. F. Cattabeni, G. Racagni, P. F. Spano & E. Costa), 325–33, Raven Press, New York.Google Scholar
Owen, F., Cross, A. J., Crow, T. J., Longden, A., Poulter, M. & Riley, G. J. (1978) Increased dopamine receptor sensitivity in schizophrenia. Lancet, ii, 223–5.Google Scholar
Owens, D. G. C. & Johnstone, E. C. (1980) The disabilities of chronic schizophrenia—their nature and the factors contributing to their development. British Journal of Psychiatry, 136, 384–5.CrossRefGoogle Scholar
Post, R. M., Fink, E., Carpenter, W. T. & Goodwin, F. F. (1975) Cerebrospinal fluid amine metabolites in acute schizophrenia. Archives of General Psychiatry, 32, 1063–9.CrossRefGoogle ScholarPubMed
Roth, R. H., Walters, J. R. & Aghajanian, G. K. (1973) Effect of impulse flow on the relase and synthesis of dopamine in the rat striatum. In Frontiers in Catecholamine Research, (eds. E. Usdin and S. H. Snyder), 567–74, Pergamon Press Inc, Oxford.Google Scholar
Schwartz, J. C., Costentin, J., Martres, M. P., Protais, P. & Baudry, M. (1978) Modulation of receptor mechanisms in the CNS: hyper- and hyposensitivity to catecholamines. Neuropharmacology, 17, 665–85.CrossRefGoogle ScholarPubMed
Stein, L. & Wise, C. D. (1971) Possible etiology of schizophrenia; progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science, 171, 1032–6.CrossRefGoogle Scholar
Sutter, J. M., Debrie, M. L. & Scotto, J. C. (1966) Recherches sur les effets psychologiques de la fluphenazine dans les psychoses chroniques. Annales Médico-Psychologiques (Paris), 124, 1933.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–9.CrossRefGoogle ScholarPubMed
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