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Preterm birth and intra-uterine growth retardation among children of women with schizophrenia

Published online by Cambridge University Press:  03 January 2018

B. E. Bennedsen ,
P. B. Mortensen ,
A. V. Olesen  and
T. B. Henriksen
B. E. Bennedsen*
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
P. B. Mortensen
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
A. V. Olesen
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
T. B. Henriksen
Affiliation:
Perinatal Research Unit, Skejby Sygehus, University Hospital in Aarhus, Århus N, Denmark
*
B. E. Bennedsen, Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, 8240 Risskov, Denmark
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Abstract

Background

There is conflicting evidence about the frequency of adverse pregnancy outcomes among women with schizophrenia.

Aims

To investigate the risk of preterm birth, low birth weight and intra-uterine growth retardation among women with schizophrenia.

Method

A total of 2212 births to 1537 women with schizophrenia in Denmark were compared with a random sample of all deliveries in Denmark in 1973–1993 (122 931 births to 72 742 women)

Results

The children of women with schizophrenia were at increased risk of preterm delivery (relative risk=1.46, 95% CI=1.19–1.79), low birth weight (relative risk=1.57, 95% 0=1.36–1.82) and small for gestational age (relative risk=1.34, 95% CI=1.17–1.53)

Conclusions

Women with schizophrenia are at increased risk of adverse pregnancy outcome. This may be associated with an increased mortality and general morbidity and risk of schizophrenia in their children.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 3 , September 1999 , pp. 239 - 245
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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