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The Prognosis of Primary Depressive Illness

Its Relationship to the Dexamethasone Suppression Test

Published online by Cambridge University Press:  02 January 2018

P. C. W. Bowie ,
A. Y. Beaini  and
L. J. Bowie
P. C. W. Bowie
Affiliation:
Leeds University
A. Y. Beaini*
Affiliation:
Leeds University
L. J. Bowie
Affiliation:
Leeds University
*
Scalebor Park Hospital, Burley-in-Wharfdale, Ilkley, West Yorkshire, LS29 7AJ
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Abstract

We followed up 30 recovered depressives for an average of 2 years. At 18 months, despite prophylactic medication, 30% had relapsed. Persistent DST suppression during the index illness was found to be a predictor of good prognosis.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 6 , June 1987 , pp. 787 - 790
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Albala, A. A., Greden, J. F., Tarika, J. & Carroll, B. J. (1981) Changes in serial dexamethasone suppression tests among unipolar depressives receiving electroconvulsive treatment. Biological Psychiatry, 16, 551–560.Google Scholar
Berger, M., Pirke, K. M., Doerr, P., Kreig, J. C. & Von Zerssen, D. (1984) The limited utility of the dexamethasone suppression test for the diagnostic process in psychiatry. British Journal of Psychiatry, 145, 372–382.Google Scholar
Bowie, P. C. W. & Beaini, A. Y. (1985) Normalisation of the dexamethasone suppression test: a correlate of clinical improvement in primary depressives. British Journal of Psychiatry, 147, 30–35.Google Scholar
Carroll, B. J., Schroeder, K., Mukhopadhyay, S., Greden, J. F. & Tarika, J. (1980) Plasma dexamethasone concentrations and Cortisol suppression response in patients with endogenous depression. Journal of Clinical Endocrinology and Metabolism, 51, 433–437.CrossRefGoogle ScholarPubMed
Coppen, A., Abou-Saleh, M., Milln, P., Metcalfe, M. & Harwood, J. & Bailey, J. (1983) Dexamethasone suppression test in depression and other psychiatric illness. British Journal of Psychiatry, 142, 498–504.Google Scholar
Fleiss, J. L., Prien, R. F., Dunner, D. L. & Fieve, R. R. (1978) Actuarial studies of the course of manic-depressive illness. Comprehensive Psychiatry, 19, 355–362.CrossRefGoogle ScholarPubMed
Glen, A. I. M., Johnson, A. L., Shepherd, M. (1984) Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial. Psychological Medicine, 14, 37–50.CrossRefGoogle ScholarPubMed
Goldberg, I. K. (1980a) Dexamethasone suppression test as indicator of safe withdrawal of antidepressant therapy. Lancet, 1, 376.CrossRefGoogle ScholarPubMed
Goldberg, I. K. (1980b) Dexamethasone suppression tests in depression and response to treatment. In Lancet, II, 92.Google Scholar
Greden, J. F., Albala, A. A., Haskett, R. F., James, N. M., Goodman, L., Steiner, M. & Carroll, B. J. (1980) Normalization of dexamethasone suppression test: a laboratory index of recovery from endogenous depression. Biological Psychiatry, 15, 449–458.Google Scholar
Kaplan, E. L. & Meier, P. (1958) Non-parametric estimation from incomplete observations. Journal of the American Statistical Association, 53, 457–481.Google Scholar
Mindham, R. H. S., Howland, C. & Shepherd, M. (1973) An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychological Medicine, 3, 5–17.CrossRefGoogle ScholarPubMed
Montgomery, S. A. & Asberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.Google Scholar
Prien, R. F., Kupfer, D. J., Mansky, P. A., Small, J. G., Tuason, V. B., Voss, C. B. & Johnson, W. E. (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Archives of General Psychiatry, 41, 1096–1104.CrossRefGoogle ScholarPubMed
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