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Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia

Published online by Cambridge University Press:  03 January 2018

Kamran Razi ,
Kimberly P. Greene ,
Michael Sakuma ,
Shuming Ge ,
Maureen Kushner  and
Lynn E. Delisi
Kamran Razi
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
Kimberly P. Greene
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
Michael Sakuma
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
Shuming Ge
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
Maureen Kushner
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
Lynn E. Delisi*
Affiliation:
Department of Psychiatry, Stony Brook, New York, USA
*
L. E. DeLisi, HSC, T-10, Department of Psychiatry, SUNY, Stony Brook, NY 11794, USA. Tel: 516-444-1612; Fax: 516-444-7536; E-mail: LDELISI@ccmail.sunysb.edu
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Abstract

Background

There have been many studies reporting reduced volume of the hippocampus or other limbic structures in patients with schizophrenia, but the literature is inconsistent.

Aims

To compare patients with either first-episode or chronic schizophrenia with controls using high-resolution volumetric magnetic resonance imaging (MRI) scans.

Method

Thirteen patients with first-episode schizophrenia, 27 with chronic schizophrenia and 31 controls had 1.5 mm coronal slices taken through the whole brain using a spoiled-grass MRI acquisition protocol.

Results

The parahippocampal gyrus was reduced significantly on the left side in patients with chronic schizophrenia compared with controls for both male and female patients, whereas the hippocampus was reduced significantly on both sides only in female patients. There were no significant reductions in any structure between patients with first-episode schizophrenia and controls.

Conclusions

Volumetric reduction seen in patients with chronic schizophrenia may be due to an active degenerative process occurring after the onset of illness.

Type
Papers
Information
The British Journal of Psychiatry , Volume 174 , Issue 6 , June 1999 , pp. 512 - 519
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

This work was funded in part by National Institute of Mental Health grant ROI-44233.

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