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Renal Function in Patients on Lithium Treatment

Published online by Cambridge University Press:  29 January 2018

R. Hällgren ,
P. O. Alm  and
K. Hellsing
R. Hällgren
Affiliation:
Department of Internal Medicine, University Hospital, Uppsala, Sweden
P. O. Alm
Affiliation:
Department of Psychiatry, University Hospital, Uppsala, Sweden
K. Hellsing
Affiliation:
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
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Summary

A cross-sectional study was performed on 66 lithium-treated patients to investigate a possibly changed kidney function, using [51Cr]-EDTA clearance, and urinary excretions of albumin and β2-microglobulin. Thirteen patients showed abnormal test results: seven had decreased glomerular filtration rate, four had increased albumin excretion and four had increased excretion of β2-microglobulin. There was no correlation between length of treatment with lithium or hypothyroidism (10 patients) and impaired renal function. Four patients had already manifested signs of renal dysfunction before lithium treatment. The high prevalence of impaired renal function among our patients is unexplained but lithium could be one possible cause.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 1 , July 1979 , pp. 22 - 27
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Avery, D. & Winokur, G. (1976) Mortality in depressed patients treated with electroconvulsive therapy and antidepressants. Archives of General Psychiatry, 33, 1029–37.CrossRefGoogle ScholarPubMed
Bohn, L. (1973) Evaluation of some qualitative and quantitative tests for proteinuria. Danish Medical Bulletin, 20, 25–8.Google ScholarPubMed
Bröchner-Mortensen, J. (1972) A simple method for the determination of glomerular filtration rate. Scandinavian Journal of Clinical and Laboratory Investigation, 30, 271–8.CrossRefGoogle ScholarPubMed
Bröchner-Mortensen, J., Jensen, S. & Rödbro, P. (1977) Delimitation of plasma creatinine concentration values for assessment of relative renal function in adult patients. Scandinavian Journal of Urology and Nephrology, 11, 257–62.Google ScholarPubMed
Chapman, A. J. & Lewis, G. (1972) Iatrogenic lithium poisoning. A case report with necropsy findings. Journal of Oklahoma State Medical Association, 65, 491–5.Google ScholarPubMed
Evan, A. P. & Ollerich, D. A. (1972) The effect of lithium carbonate on the structure of the rat kidney. American Journal of Anatomy, 134, 97–106.CrossRefGoogle ScholarPubMed
Forrest, I. N., Cohen, A. D., Torretti, J., Himmelshoch, I. M. & Epstein, F. M. (1974) On the mechanism of lithium-induced diabetes insipidus in man and the rat. Journal of Clinical Investigation, 53, 1115–23.CrossRefGoogle ScholarPubMed
Hestbech, J., Hansen, H. E., Amdisen, A. & Olsen, S. (1977) Chronic renal lesions following long-term treatment with lithium. Kidney International, 12, 205–13.CrossRefGoogle ScholarPubMed
Katz, A. I., Emmanuel, D. S. & Lindheimer, M. D. (1975) Thyroid hormone and the kidney. Nephron, 15, 223–49.CrossRefGoogle ScholarPubMed
Lizana, J. & Hellsing, K. (1974) Polymer enhancement of automated immunological nephelometric analysis, as illustrated by determination of urinary albumin. Clinical Chemistry, 20, 415–20.CrossRefGoogle ScholarPubMed
Lindstedt, G., Nilsson, L-Å., Wålinder, J., Skott, A. & Öhman, R. (1977) On the prevalence, diagnosis and management of lithium-induced hypothyroidism in psychiatric patients. British Journal of Psychiatry, 130, 452–8.CrossRefGoogle ScholarPubMed
Ødegaard, Ø. (1952) The excess mortality of the insane. Acta Psychiatrica Scandinavica, 27, 353–67.CrossRefGoogle Scholar
Peterson, P. A., Evrin, P.-E. & Berggård, I. (1969) Differentiation of glomerular, tubular and normal proteinuria, determinations of urinary excretion of β2-microglobulin, albumin and total protein. Journal of Clinical Investigation, 48, 1189–98.CrossRefGoogle Scholar
Radomski, J. L., Fuyat, H. N., Nelson, A. A. & Smith, P. K. (1950) The toxic effects, excretion and distribution of lithium chloride. Journal of Pharmacological and Experimental Therapy, 100, 429–44.Google ScholarPubMed
Rennie, I. B. D. & Keen, H. (1967) Evaluation of clinical methods for detecting proteinuria. Lancet, 2, 489–92.Google ScholarPubMed
Robak, O. H. & Saetermo, R. (1975) Behandling av litiuminducert polyuri. Tidskrift för Nordisk Laegeforening, 95, 436–9.Google Scholar
Rorsman, B. (1974) Mortality among psychiatric patients. Acta Psychiatrica Scandinavica, 50, 354–75.CrossRefGoogle ScholarPubMed
Salomon, M. I., Di Scala, V., Grishman, E., Brenner, J. & Chung, J. (1967) Renal lesions in hypothyroidism: a study based on kidney biopsies. Metabolism, 16, 846–52.CrossRefGoogle ScholarPubMed
Smith, W. H. (1951) The Kidney. New York: Oxford University Press.Google Scholar
Tsuang, M. T. & Woolson, R. F. (1977) Mortality in patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 130, 162–6.CrossRefGoogle ScholarPubMed
Villeneuve, A., Gautier, J., Jus, A. & Perron, D. (1974) The effect of lithium on thyroid in man. International Journal of Clinical Pharmacology, 9, 75–80.Google ScholarPubMed
Weeke, E. & Weeke, B. (1973) Urinary serum proteins. The excretion of nine serum proteins in normal persons and patients undergoing renal transplantation. Protides of Biological Fluids, 21, 363–9.Google Scholar
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