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Serum Proteins in Huntington's Chorea

Published online by Cambridge University Press:  29 January 2018

Valerie Cowie  and
D. B. Gammack
Valerie Cowie
Affiliation:
Psychiatric Genetics Research Unit, Maudsley Hospital, London, S.E.5
D. B. Gammack
Affiliation:
Department of Biochemistry, Institute of Psychiatry, Maudsley Hospital, London, S.E.5
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Extract

Huntington's chorea is transmitted by a rare autosomal Mendelian dominant gene. Its hereditary transmission is facilitated by a late onset of the condition in many cases. Often the first signs are not seen until late in the reproductive period, so that it is not uncommon for a patient already to have produced a number of children before the diagnosis is made. On a theoretical basis, 50 per cent. of these offspring are at risk for carrying the gene and consequently for developing the condition themselves.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 488 , July 1966 , pp. 723 - 726
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

Bruyn, G. W. and Leguin, R. M. (1964). “Huntington's chorea”. Lancet, ii, 1300.Google Scholar
Cowie, V. and Seakins, J. W. T. (1962). “Urinary alanine excretor in a Huntington's chorea family”. J. ment. Sci., 108, 427–431.Google Scholar
Faurbye, A. and Clausen, J. (1964). “Changes in serum proteins and cerebrospinal fluid proteins during pharmacotherapy of psychoses”. Acta psychiat. Scand., 40, 107–116.Google Scholar
Fessel, W. J. and Grunbaum, B. W. (1961). “Electrophoretic and analytical ultracentrifuge studies in sera of psychotic patients: elevation of γ-globulins and macroglobulins and splitting of α2-globulins”. Ann. intern. Med., 54, 1134–1145.Google Scholar
Gammack, D. B. and Hector, R. I. (1965). “A study of serum proteins in acute schizophrenia”. Clin. Sci., 28, 469–475.Google Scholar
Mayer Gross, W. Slater, E. and Roth, M. (1960). Clinical Psychiatry. London: Cassell, p. 496.Google Scholar
McMenemey, W. H. (1961). “Immunity mechanisms in neurological disease”. Proc. Roy. Soc. Med., 54, 127–136.Google Scholar
Minski, L. and Guttmann, E. (1938). “Huntington's chorea: a study of thirty-four families”. J. ment. Sci., 84, 21–96.Google Scholar
Patterson, R. M. Bagchi, B. K. and Test, A. (1948). “Prediction of Huntington's chorea; electroencephalographic and genetic study”. Amer. J. Psychiat., 104, 786–797.Google Scholar
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