Hostname: page-component-745bb68f8f-l4dxg Total loading time: 0 Render date: 2025-02-04T17:02:45.309Z Has data issue: false hasContentIssue false
  • English
  • Français

Tiapride in the Prevention of Relapse in Recently Detoxified Alcoholics

Published online by Cambridge University Press:  02 January 2018

G. K. Shaw ,
S. Waller ,
S. K. Majumdar ,
J. L. Alberts ,
C. J. Latham  and
G. Dunn
G. K. Shaw*
Affiliation:
Bexley Hospital
S. Waller
Affiliation:
Bexley Hospital
S. K. Majumdar
Affiliation:
Bexley Hospital
J. L. Alberts
Affiliation:
Synthelabo Recherche, France
C. J. Latham
Affiliation:
Goldsmiths' College, London
G. Dunn
Affiliation:
Department of Biostatistics, Institute of Psychiatry, London
*
G. K. Shaw, Honorary Consultant Psychiatrist, Bexley Hospital, Old Bexley Lane, Bexley, Kent DA5 2BW
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The aim was to investigate the effect of tiapride (100 mg three times a day for at least one month) on outcome following detoxification.

Method

The setting was a tertiary referral centre. The study design was randomised, double-blind, and placebo-controlled. One hundred routinely admitted alcohol-dependent patients were entered, and 54 completed the trial. Outcome was assessed by considering drinking status at three months and six months follow-up, and by comparing psychological status at intake and follow-up using the Crown-Crisp Experiential Index, the Litman Self-esteem scale and a Satisfaction with Life Situations scale. We also compared performance over the six months before admission with the three and six months of follow-up on measures of health, social and drinking variables.

Results

Tiapride proved better (usually at statistically highly significant levels) than placebo at promoting: abstinence, self-esteem, and satisfaction with life situations; and at reducing: alcohol consumption, use of health service resources, and levels of neuroticism.

Conclusions

Tiapride merits serious consideration in the longer-term treatment of alcoholic patients.

Type
Papers
Information
The British Journal of Psychiatry , Volume 165 , Issue 4 , October 1994 , pp. 515 - 523
Copyright
Copyright © Royal College of Psychiatrists, 1994 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bonnaffoux, D., Jeanparis, F., Bourgeat, P., et al (1982) Follow-up treatment after alcohol withdrawal: results after two years in 200 cases. La Semaine des Hôpitaux de Paris, 58, 2079–2081.Google Scholar
Crown, S. & Crisp, A. H. (1979) Crown-Crisp Experiential Index. London: Hodder & Stoughton.Google Scholar
Duckert, F., Johnsen, J., Amundsen, A., et al (1992). Co-variation between biological markers and self-reported alcohol consumption. Alcohol and Alcoholism, 27, 545–555.Google ScholarPubMed
Keso, L. & Salaspuro, M. (1990) Comparative value of self-report and blood tests in assessing outcome amongst alcoholics. British Journal of Addiction, 85, 209–215.CrossRefGoogle ScholarPubMed
Litman, G., Stapleton, J., Oppenheim, A. N., et al (1983) An instrument for measuring coping behaviour in hospitalised alcoholics: implications for relapse, prevention, treatment. British Journal of Addiction, 78, 269–276.CrossRefGoogle ScholarPubMed
Midanik, L. T. (1988) Validity of self-reported alcohol use: a literature review and assessment. British Journal of Addiction, 83, 1019–1029.CrossRefGoogle ScholarPubMed
Registrar General (1980) Classification of Occupations, Survey. London: Office of Population Census.Google Scholar
Sabourin, A. (1985) Effects of various therapeutic procedures on maintenance of abstinence in alcoholic patients: a statistical analysis. La Semaine des Hôpitaux de Paris, 61, 669–676.Google Scholar
Shaw, G. K., Majumdar, S. K., Waller, S., et al (1987) Tiapride in the long-term management of alcoholics of anxious or depressive temperament. British Journal of Psychiatry, 150, 164–168.CrossRefGoogle ScholarPubMed
Shaw, G. K., Waller, S., McDougall, S., et al (1990) Alcoholism: a follow-up study of participants in an alcohol treatment programme. British Journal of Psychiatry, 157, 190–196.CrossRefGoogle Scholar
Stockwell, T., Murphy, D. & Hodgson, R. (1983) The severity of alcohol dependence questionnaire: its use, reliability and validity. British Journal of Addiction, 78, 145–155.CrossRefGoogle ScholarPubMed
Straus, R. & Bacon, S. D. (1951) Alcoholism and social stability: a study of occupational integration on 2023 male clinic patients. Quarterly Journal of Studies on Alcohol, 12, 231–260.CrossRefGoogle Scholar
Wise, R. A. & Bozarth, M. A. (1987) A psychomotor stimulant theory of addiction. Psychological Review, 94, 469–492.CrossRefGoogle ScholarPubMed
Wise, R. A. & Rompre, P-P. (1989) Brain deopamine and reward. Annual Review of Psychology, 40, 191–225.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.