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Transcallosal inhibition and motor conduction studies in patients with schizophrenia using transcranial magnetic stimulation

Published online by Cambridge University Press:  03 January 2018

B. Boroojerdi ,
R. Töpper ,
H. Foltys  and
U. Meincke
B. Boroojerdi*
Affiliation:
Department of Neurology, University Hospital, RWTH Aachen, Germany
R. Töpper
Affiliation:
Department of Neurology, University Hospital, RWTH Aachen, Germany
H. Foltys
Affiliation:
Department of Neurology, University Hospital, RWTH Aachen, Germany
U. Meincke
Affiliation:
Department of Psychiatry and Psychotherapy, University Hospital, RWTH Aachen, Germany
*
B. Boroojerdi, National Institute of Neurological Disorders and Stroke, NIH, Building 10, Room 5N234, 10 Center Drive, Bethesda, MD 20892-1430, USA. Tel: + 1 301 4023499; fax: + 1 301 4021007; e-mail: boroojer@codon.nih.gov
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Abstract

Background

Transcranial magnetic stimulation of the motor cortex may not only elicit excitatory responses in hand muscles contralateral to the stimulated hemisphere, but may also suppress tonic voluntary electromyogram activity in muscles ipsilateral to the stimulation. This inhibition is mediated between the motor cortices via the corpus callosum.

Aims

To investigate motor excitability and interhemispheric (transcallosal) connections in patients with schizophrenia.

Method

Transcallosal inhibition and motor conduction parameters were investigated in ten patients with schizophrenia and in ten age- and gender-matched healthy subjects.

Results

Transcallosal conduction time (TCT) and duration of the inhibition were significantly longer in patients with schizophrenia (mean (s.d.)): TCT, 12.4 (2.9) ms in normal subjects and 15.3 (2.6) ms in patients (P=0.03); mean duration, 34.1 (4.9) ms in normal subjects and 51.9 (16.8) ms in patients (P=0.01).

Conclusions

Magnetic motor conduction parameters are unaltered in schizophrenia, but transcallosal inhibition is significantly delayed and prolonged. This may indicate abnormal function of the corpus callosum in these patients.

Type
Preliminary Reports
Information
The British Journal of Psychiatry , Volume 175 , Issue 4 , October 1999 , pp. 375 - 379
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Grants received from the Deutsche Forschungsgemeinschaft and the University Hospital, Aachen, Germany.

References

Abarbanel, J. M., Lemberg, T., Yaroslavski, U., et al (1996) Electrophysiological responses to transcranial magnetic stimulation in depression and schizophrenia. Biological Psychiatry, 40, 148–150.Google Scholar
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn). Washington, DC: APA.Google Scholar
Barker, A. T., Jalinous, R. & Freeston, I. L. (1985) Non-invasive magnetic stimulation of human motor cortex (letter). Lancet, i, 1106–1107.CrossRefGoogle Scholar
Boroojerdi, B., Diefenbach, K. & Ferbert, A. (1996) Transcallosal inhibition in cortical and subcortical cerebral vascular lesions. Journal of Neurological Sciences, 144, 160–170.Google Scholar
Boroojerdi, B., Hungs, M., Mull, M., et al (1998) Interhemispheric inhibition in patients with multiple sclerosis. Electroencephalography and Clinical Neurophysiology, 109, 230–237.CrossRefGoogle ScholarPubMed
Coger, R. W. & Serafetinides, E. A. (1990) Schizophrenia, corpus calbsum, and interhemispheric communication: a review. Psychiatry Research, 34, 163–184.Google Scholar
Cooper, J. E., Andrews, H. & Barber, C. (1985) Stable abnormalities in the latéralisation of early cortical somatosensory evoked potentials in schizophrenic patients. British Journal of Psychiatry, 146, 585 593.CrossRefGoogle ScholarPubMed
David, A. S. (1994) Schizophrenia and the corpus callosum: developmental, structural and functional relationships. Behavioural Brain Research, 64, 203–211.Google Scholar
Forbert, A., Priori, A., Rothwell, J. C., et al (1992) Interhemispheric inhibition of the human motor cortex. Journal of Physiology, 453, 525–546.CrossRefGoogle Scholar
Günther, W., Petsch, R., Steinberg, R., et al (1991) Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biological Psychiatry 29. 535–555.CrossRefGoogle ScholarPubMed
Gulman, N. C., Wlidschiotz, G. & Orbaek, K. (1982) Alteration of interhemispheric conduction through corpus callosum in chronic schizophrenia. Biological Psychiatry 17, 585–594.Google Scholar
Jacobson, L. K., Giedd, J. N., Rajapakse, J. C., et al (1997) Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Research, 68, 77–86.CrossRefGoogle Scholar
Kaneko, K., Kawai, S., Fuchigami, Y., et al (1996) The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain. Electroencephalography and Clinical Neurophysiology, 101, 478–482.Google Scholar
Kay, S. R., Fiszbein, A. & Opter, L. A. (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261–276.Google Scholar
Masur, H., Althoff, S., Erim, Y., et al (1998) Postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with drug-induced parkinsonism and in healthy individuals. International Clinical Psychopharmacohgy, 13, 79–82.CrossRefGoogle ScholarPubMed
Merrin, A. L., Floyd, T. C. & Fein, G. (1989) EEG coherence in unmedicated schizophrenic patients. Biological Psychiatry 25, 60–66.Google Scholar
Meyer, B. U., Röricht, S., Gräfin von Einsidel, H., et al (1995) Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain, 118, 429–440.Google Scholar
Meyer, B. U., Röricht, S., & Woiciechowsky, C. (1998) Topography of fibres in the human corpus callosum mediating interhemispheric inhibition between the motor cortices. Annals of Neurology, 43, 360–369.CrossRefGoogle ScholarPubMed
Puri, B. K. & Lewis, S. W. (1996) Transcranial magnetic stimulation in psychiatric research. British Journal of Psychiatry, 169, 675–677.Google Scholar
Puri, B. K., Davey, N. J., Ellaway, P. H., et al (1996a) An investigation of motor function in schizophrenia using transcranial magnetic stimulation of the motor cortex. British Journal of Psychiatry, 169, 690–695.Google Scholar
Puri, B. K., Davey, N. J., & Lewis, S. W. (1996b) The effects of antipsychotic medication on electromyographic responses to transcranial magnetic stimulation of the motor cortex in schizophrenic patients (abstract). Schizophrenia Research, 18, 234.Google Scholar
Rossini, P. M., Barker, A. T., Berardelli, A., et al (1994) Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalography and Clinical Neurophysiology, 91, 79–92.Google Scholar
Rothwell, J. C., Colebatch, J., Britton, T. C., et al (1991) Physiological studies in patients with mirror movements and agenesis of the corpus callosum. Journal of Physiology, 438, 34P.Google Scholar
SAS Institute (1989) SAS/STAT User's Guide (version 6. vol. 1). Cary, NC: SAS Institute.Google Scholar
Schroder, J., Buchsbaum, M. S., Siegel, B. V., et al (1995) Structural and functional correlates of subsyndromes in chronic schizophrenia. Psychopathology, 28, 38–45.Google Scholar
Tress, K. H., Caudrey, D. H. & Mehta, B. (1983) Tactile-evoked potentials in schizophrenia. Interhemispheric transfer and drug effects. British Journal of Psychiatry, 143, 156–164.Google Scholar
Wassermann, E. M., Fuhr, P., Cohen, L. G., et al (1991) Effects of transcranial magnetic stimulation on ipsilateral muscles. Neurology, 41, 1795–1799.Google Scholar
Woodruff, P. W. R., McManus, I. C. & David, A. S. (1995) Meta-analysis of corpus callosum size in schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry, 58, 457–461.Google Scholar
Woodruff, P. W. R., Phillips, M. L., Rushe, T., et al (1997) Corpus callosum size and inter-hemispheric function in schizophrenia. Schizophrenia Research, 23, 189–196.Google Scholar
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