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Trials of Lithium, Chlorpromazine and Amitriptyline in Schizoaffective Patients

Published online by Cambridge University Press:  29 January 2018

I. F. Brockington ,
R. E. Kendell ,
J. M. Kellett ,
S. H. Curry  and
S. Wainwright
I. F. Brockington
Affiliation:
University Hospital of South Manchester, West Didsbury, Manchester 20
R. E. Kendell
Affiliation:
Edinburgh University
J. M. Kellett
Affiliation:
St George's Hospital, London
S. H. Curry
Affiliation:
London Hospital Medical School
S. Wainwright
Affiliation:
Institute of Psychiatry, London
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Summary

Two drug trials in schizoaffective patients are reported. Nineteen ‘schizomanic’ patients were treated for one month, on a double blind basis, with chlorpromazine or lithium and 41 ‘schizodepressive’ patients with amitriptyline, chlorpromazine or both.

In the schizodepressive patients there was a trend to a better response to chlorpromazine, but drug response generally was poor, only 20 per cent of patients recovering within the month. In the schizomanic patients lithium seemed as effective as chlorpromazine, which supports the view that these patients were suffering from a variant of mania.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 2 , August 1978 , pp. 162 - 168
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Croughan, J. L., Welner, A. & Robins, E. (1974) The group of schizoaffective and related psychoses—critique, record, follow-up and family studies. Archives of General Psychiatry, 31, 632–7.CrossRefGoogle Scholar
Fink, M., Klein, D. F. & Kramer, J. C. (1965) Clinical efficacy of chlorpromazine-procyclidine combination, imipramine and placebo in depressive disorders. Psychopharmacologia, 7, 27–36.CrossRefGoogle ScholarPubMed
Greenblatt, M., Grosser, G. H. & Wechsler, H. (1964) Differential response of hospitalized depressed patients to somatic therapy. American Journal of Psychiatry, 120, 935–43.CrossRefGoogle ScholarPubMed
Glassman, A. H., Kantor, S. J. & Shostak, M. (1975) Depression, delusions and drug response. American Journal of Psychiatry, 132, 716–19.Google Scholar
Goldberg, S. C., Klerman, G. L. & Cole, J. O. (1965) Changes in schizophrenic psychopathology and ward behaviour as a function of phenothiazine treatment. British Journal of Psychiatry, 111, 120–33.Google Scholar
Gram, L. F. & Overo, K. F. (1972) Drug interaction: inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. British Medical Journal, 1, 463–5.Google Scholar
Hordern, A., Holt, N. F., Burt, C. G. & Gordon, W. F. (1963) Amitriptyline in depressive states. British Journal of Psychiatry, 109, 815–25.CrossRefGoogle ScholarPubMed
Johnson, G. (1970) Differential response to lithium carbonate in manic depressive and schizoaffective disorders. Diseases of the Nervous System, 9, 613–15.Google Scholar
Johnson, G. Gershon, S., Burdock, E. I., Floyd, A. & Hekimian, L. (1971) Comparative effects of lithium and chlorpromazine in the treatment of acute manic states. British Journal of Psychiatry, 119, 267–76.Google Scholar
Kantor, S. J. & Glassman, A. H. (1977) Delusional depressions: Natural history and response to treatment. British Journal of Psychiatry, 131, 351–60.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
Overall, J. E., Hollister, L. E., Meyer, F., Kimbell, I. & Shelton, J. (1964) Imipramine and thioridazine in depressed and schizophrenic patients. Journal of the American Medical Association, 189, 93–6.Google ScholarPubMed
Paykel, E. S., Price, J. S., Gillan, R. U., Palmai, G. & Chesser, E. S. (1968) A comparative trial of imipramine and chlorpromazine in depressed patients. British Journal of Psychiatry, 114, 1281–7.Google Scholar
Perris, C. (1974) Study of cycloid psychosis. Acta Psychiatrica Scandinavica, Supplement 253.Google Scholar
Prien, R. F., Caffey, E. M. & Klett, C. J. (1972) A comparison of lithium carbonate and chlorpromazine in the treatment of excited schizoaffectives. Archives of General Psychiatry, 27, 182–9.CrossRefGoogle ScholarPubMed
Procci, W. (1976) Schizoaffective psychosis: fact or fiction ? Archives of General Psychiatry, 33, 1167–78.Google Scholar
Shopsin, B., Kim, S. S. & Gershon, S. (1971) A controlled study of lithium vs. chlorpromazine in acute schizophrenics. British Journal of Psychiatry, 119, 435–40.Google Scholar
Takahashi, R., Sakuma, A., Itoh, K., Itoh, H., Kurihara, M., Saito, M. & Watanabe, M. (1975) Comparison of efficacy of lithium carbonate and chlorpromazine in mania. Archives of General Psychiatry, 32, 1310–18.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press.Google Scholar
Zall, H., Therman, P. G. & Myers, J. M. (1968) Lithium carbonate: a clinical study. American Journal of Psychiatry, 125, 549–55.Google Scholar
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