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Urinary Catecholamine Metabolite and Tribulin Output During Lactate Infusion

Published online by Cambridge University Press:  02 January 2018

Angela Clow ,
Vivette Glover ,
M. W. Weg ,
P. L. Walker ,
D. V. Sheehan ,
D. B. Carr  and
M. Sandler
Angela Clow
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital
Vivette Glover
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital
M. W. Weg
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital
P. L. Walker
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital Department of Biochemistry, Pinderfields General Hospital, Wakefield
D. V. Sheehan
Affiliation:
Massachusetts General Hospital; now at University South Florida Psychiatry Center, Tampa
D. B. Carr
Affiliation:
Endocrine Unit, Massachusetts General Hospital, Boston
M. Sandler*
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital
*
Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG
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Abstract

Urinary output of homovanillic acid and 4-hydroxy-3-methoxymandelic acid was decreased both in patients with panic attacks and in normal controls during lactate infusion, whereas that of tribulin (an endogenous monoamine oxidase inhibitor and benzodiazepine receptor binding inhibitor) was increased. There was no change in urinary excretion of any of these compounds during saline infusion. These findings provide further evidence of a link between tribulin output and stress and anxiety in man and point to its possible in vivo action as a monoamine oxidase inhibitor.

Type
Papers
Information
The British Journal of Psychiatry , Volume 152 , Issue 1 , January 1988 , pp. 122 - 126
Copyright
Copyright © The Royal College of Psychiatrists 

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