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Urinary Excretion of Cyclic Amp and Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

B. L. Brown ,
J. G. Salway ,
J. D. M. Albano ,
R. P. Hullin  and
R. P. Ekins
B. L. Brown
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
J. G. Salway
Affiliation:
Biochemistry Department, University of Leeds, Leeds, LS2 9LS
J. D. M. Albano
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
R. P. Hullin
Affiliation:
Biochemistry Department, University of Leeds, Leeds, LS2 9LS
R. P. Ekins
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
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Extract

Recently several communications have been published implicating impaired 3′5′ cyclic adenosine monophosphate (cyclic AMP) metabolism as a causal factor in affective disorders (1, 3, 7, 8, 9, 11). In particular, the urinary excretion of cyclic AMP in manic patients is reported to be increased compared with that of normal subjects, whereas in depressed patients a decreased excretion has been observed (1, 7, 8, 9). These findings form the basis of a theory explaining the systemic and mental symptoms of affective disorders (1).

Type
Papers
Information
The British Journal of Psychiatry , Volume 120 , Issue 557 , April 1972 , pp. 405 - 408
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

1. Abdulla, Y. H., and Hamadah, K. (1970). ‘3′5′ cyclic adenosine monophosphate in depression and mania.’ Lancet, i, 378–81.Google Scholar
2. Brown, B. L., Albano, J. D. M., Ekins, R. P., Sgherzi, A. M., and Tampion, W. (1971). ‘A simple and sensitive saturation assay method for the measurement of adenosine 3′5′ cyclic monophosphate.’ Biochem. J., 121, 561–2.Google Scholar
3. Dousa, T., and Hechter, O. (1970). ‘Lithium and brain adenyl cyclase.’ Lancet, i, 834–5.Google Scholar
4. Eccleston, D., Loose, R., Pullar, I. A., and Sugden, R. F. (1970). ‘Exercise and urinary excretion of cyclic AMP.’ Lancet, i, 612–3.Google Scholar
5. Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967). ‘Body water variations in manic-depressive psychosis.’ Brit. J. Psychiat., 113, 584–92.Google ScholarPubMed
6. Krishna, G., and Birnbaumer, L. (1970). ‘On the assay of adenyl cyclase.’ Anal. Biochem., 35, 393–7.Google Scholar
7. Paul, M. I., Ditzion, B. R., and Janowsky, D. S. (1970). ‘Affective illness and cyclic AMP excretion.’ Lancet, i, 88.CrossRefGoogle Scholar
8. Paul, M. I., Pauk, G. L., and Janowsky, D. S. (1970). ‘Urinary adenosine 3′5′-monophosphate excretion in affective disorders.’ Amer. J. Psychiat., 126, 1493–7.Google Scholar
9. Paul, M. I. Cramer, H., and Goodwin, F. K. (1970). ‘Urinary cyclic AMP in affective illness.’ Lancet, i, 996.Google Scholar
10. Paul, M. I. Cramer, H., and Bunney, W. E. (1971). ‘Urinary adenosine 3′5′-monophosphate in the switch process from depression to mania.’ Science, 171, 300–3.Google Scholar
11. Ramsden, E. N. (1970). ‘Cyclic AMP in depression and mania.’ Lancet, ii, 108.CrossRefGoogle Scholar
12. Robison, G. A., Coppen, A. J., Whybrow, P. C., and Prange, A. J. (1970). ‘Cyclic AMP in affective disorders.’ Lancet, ii, 1038–9.Google Scholar
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