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Viloxazine in the Treatment of Depressive Neurosis: A Controlled Clinical Study with Doxepin and Placebo

Published online by Cambridge University Press:  29 January 2018

Joseph P. McEvoy ,
William F. Sheridan ,
W. R. C. Stewart Jr. ,
Thomas A. Ban ,
William H. Wilson ,
William Guy  and
J. David Schaffer
Joseph P. McEvoy
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William F. Sheridan
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
W. R. C. Stewart Jr.
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
Thomas A. Ban
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William H. Wilson
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William Guy
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
J. David Schaffer
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
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Summary

In a four-week, double-blind, clinical trial thirty-one patients with depressive neurosis were treated with viloxazine, doxepin, or placebo. There were no differences among the three groups in therapeutic effects. Many depressed out-patients improve on placebo. Viloxazine hydrochloride is one of a series of compounds developed to explore the central nervous system activity of the aryloxypropanolamine type of β-adreno-receptor antagonists. Initial clinical studies support the hypothesis that viloxazine has antidepressant properties in man (Bayliss et al, 1974; Bereen, 1973; Pichot et al, 1975; Tsegos and Ekdawi, 1974).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 5 , November 1980 , pp. 440 - 443
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

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