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Empirical Evaluation of the Genetic Similarity of Samples From Twin Registries in Australia and the Netherlands Using 359 STRP Markers

Published online by Cambridge University Press:  21 February 2012

Patrick F. Sullivan ,
Grant W. Montgomery ,
Jouke Jan Hottenga ,
Naomi R. Wray ,
Dorret I. Boomsma  and
Nicholas G. Martin
Patrick F. Sullivan*
Affiliation:
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. pfsulliv@med.unc.edu
Grant W. Montgomery
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
Jouke Jan Hottenga
Affiliation:
Department of Biological Psychology, Free University, Amsterdam, the Netherlands.
Naomi R. Wray
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, Free University, Amsterdam, the Netherlands.
Nicholas G. Martin
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
*
*Address for correspondence: Dr Sullivan, Department of Genetics, CB#7264, 4109D Neurosciences Research Building, University of North Carolina, Chapel Hill, NC, 27599-7264, USA.

Abstract

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One way to achieve the large sample sizes required for genetic studies of complex traits is to combine samples collected by different groups. It is not often clear, however, whether this practice is reasonable from a genetic perspective. To assess the comparability of samples from the Australian and the Netherlands twin studies, we estimated Fst (the proportion of total genetic variability attributable to genetic differences between cohorts) based on 359 short tandem repeat polymorphisms in 1068 individuals. Fst was estimated to be 0.30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses.

Type
Articles
Information
Twin Research and Human Genetics , Volume 9 , Issue 4 , 01 August 2006 , pp. 600 - 602
Copyright
Copyright © Cambridge University Press 2006