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Genome-Wide Linkage Analysis of Hemodynamic Parameters Under Mental and Physical Stress in Extended Omani Arab Pedigrees: The Oman Family Study

Published online by Cambridge University Press:  21 February 2012

Mohammed O. Hassan ,
Deepali Jaju ,
V. Saroja Voruganti ,
Riad A. Bayoumi ,
Sulayma Albarwani ,
Saeed Al-Yahyaee ,
Afshin Aslani ,
Harold Snieder ,
Juan C. Lopez-Alvarenga  and
Zahir M. Al-Anqoudi
...Show all authors
Mohammed O. Hassan*
Affiliation:
College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman. mhassan@squ.edu.om
Deepali Jaju
Affiliation:
College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
V. Saroja Voruganti
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America.
Riad A. Bayoumi
Affiliation:
College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
Sulayma Albarwani
Affiliation:
College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
Saeed Al-Yahyaee
Affiliation:
College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
Afshin Aslani
Affiliation:
Unit of Genetic Epidemiology & Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Harold Snieder
Affiliation:
Unit of Genetic Epidemiology & Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Juan C. Lopez-Alvarenga
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America.
Zahir M. Al-Anqoudi
Affiliation:
Ministry of Health, Muscat, Sultanate of Oman.
Behrooz Z. Alizadeh
Affiliation:
Unit of Genetic Epidemiology & Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Anthony G. Comuzzie
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America.
*
*ADDRESS FOR CORRESPONDENCE: Mohammed O Hassan, MD, PhD, FRCP. Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, PC 123, Al-Khod, Muscat, Sultanate of Oman.

Abstract

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Background: We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests. Methods: The Oman Family Study subjects (N = 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR. Results: Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For △WCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For △CPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.

Keywords

genome-widelinkageArab pedigreeshaemodynamicsstress
Type
Articles
Information
Twin Research and Human Genetics , Volume 14 , Issue 3 , 01 June 2011 , pp. 257 - 267
Copyright
Copyright © Cambridge University Press 2011