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Linkage Disequilibrium and Its Expectation in Human Populations

Published online by Cambridge University Press:  21 February 2012

John A. Sved
John A. Sved*
Affiliation:
School of Biological Sciences, University of Sydney, Australia. jsved@usyd.edu.au
*
*Address for correspondence: John A. Sved, Biology A12, Sydney University NSW 2006, Australia.

Abstract

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Linkage disequilibrium (LD), the association in populations between genes at linked loci, has achieved a high degree of prominence in recent years, primarily because of its use in identifying and cloning genes of medical importance. The field has recently been reviewed by Slatkin (2008). The present article is largely devoted to a review of the theory of LD in populations, including historical aspects.

Keywords

linkage disequilibriumlinked identity-by-descentLD mappingcomposite DHapmap
Type
Articles
Information
Twin Research and Human Genetics , Volume 12 , Issue 1 , 01 February 2009 , pp. 35 - 43
Copyright
Copyright © Cambridge University Press 2009