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The Osaka University Aged Twin Registry: Epigenetics and Identical Twins Discordant for Aging-Dependent Diseases

Published online by Cambridge University Press:  21 February 2012

Kazuo Hayakawa ,
Kenji Kato ,
Miyuki Onoi ,
Cai Yang-Ping ,
Masao Kanamori ,
Syuichi Doi ,
Chisato Hayashi ,
Hiroyuki Kikuchi ,
Reiko Nishihara  and
Kensuke Kadota
Kazuo Hayakawa*
Affiliation:
Faculty of Medicine, Osaka University, Japan. hayakawa@sahs.med.osaka-u.ac.jp
Kenji Kato
Affiliation:
Karolinska Institutet, Sweden.
Miyuki Onoi
Affiliation:
Faculty of Medicine, Osaka University, Japan.
Cai Yang-Ping
Affiliation:
Faculty of Medicine, Osaka University, Japan.
Masao Kanamori
Affiliation:
Biwako Seikei Sports College, Japan.
Syuichi Doi
Affiliation:
School of Medicine, Kinki University, Japan.
Chisato Hayashi
Affiliation:
Faculty of Medicine, Osaka University, Japan.
Hiroyuki Kikuchi
Affiliation:
Faculty of Medicine, Osaka University, Japan.
Reiko Nishihara
Affiliation:
Faculty of Medicine, Osaka University, Japan.
Kensuke Kadota
Affiliation:
Faculty of Medicine, Osaka University, Japan.
*
*Address for correspondence: Kazuo Hayakawa, Department of Health Promotion Science, Faculty of Medicine, Osaka University, 1–7 Yamadaoka, Suita City, Osaka-Fu, Japan.

Abstract

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The Osaka University Aged Twin Registry (OUATR) is the largest adult twin registry in Japan. Since its establishment in 1974, the OUATR has conducted a number of studies with particular focus on the environmental contribution to physical–cognitive–mental aging, longevity and aging-dependent diseases in later adulthood. The registry consists of 12,000 pairs of Japanese twins born between 1900 and 1935. Two hundred and fifty pairs of twins have undergone comprehensive medical examination to date. Follow-up questionnaires have been mailed out on a regular basis, for the purpose of checking current vital statuses, health conditions, and so forth. The main objective of this longitudinal twin study is to contribute to the prevention of lifestyle-related diseases and the promotion of successful aging.

Type
Articles/Japan
Information
Twin Research and Human Genetics , Volume 9 , Issue 6 , 01 December 2006 , pp. 808 - 810
Copyright
Copyright © Cambridge University Press 2006