Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T10:55:35.117Z Has data issue: false hasContentIssue false
  • English
  • Français

Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study

Published online by Cambridge University Press:  21 February 2012

Dominik J. Jedlinski ,
Plamena N. Gabrovska ,
Stephen R. Weinstein ,
Robert A. Smith  and
Lyn R. Griffiths
Dominik J. Jedlinski
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia; Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Plamena N. Gabrovska
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia.
Stephen R. Weinstein
Affiliation:
Department of Pathology, Gold Coast Hospital, Southport, Australia.
Robert A. Smith
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia.
Lyn R. Griffiths*
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia. l.griffiths@griffith.edu.au
*
*ADDRESS FOR CORRESPONDENCE: Professor Lyn Griffiths, Genomics Research Centre, Griffith University Gold Coast Campus, Parklands Drive, Southport QLD 4215, Australia.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.

Keywords

breast cancermicro-RNAcancer riskSNPrs11614913
Type
Articles
Information
Twin Research and Human Genetics , Volume 14 , Issue 5 , 01 October 2011 , pp. 417 - 421
Copyright
Copyright © Cambridge University Press 2011