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Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study

Published online by Cambridge University Press:  21 February 2012

Dominik J. Jedlinski ,
Plamena N. Gabrovska ,
Stephen R. Weinstein ,
Robert A. Smith  and
Lyn R. Griffiths
Dominik J. Jedlinski
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia; Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Plamena N. Gabrovska
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia.
Stephen R. Weinstein
Affiliation:
Department of Pathology, Gold Coast Hospital, Southport, Australia.
Robert A. Smith
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia.
Lyn R. Griffiths*
Affiliation:
Genomics Research Centre, Griffith Health Institute, Griffith University Gold Coast, Southport, Australia. l.griffiths@griffith.edu.au
*
*ADDRESS FOR CORRESPONDENCE: Professor Lyn Griffiths, Genomics Research Centre, Griffith University Gold Coast Campus, Parklands Drive, Southport QLD 4215, Australia.

Abstract

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microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.

Keywords

breast cancermicro-RNAcancer riskSNPrs11614913
Type
Articles
Information
Twin Research and Human Genetics , Volume 14 , Issue 5 , 01 October 2011 , pp. 417 - 421
Copyright
Copyright © Cambridge University Press 2011