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[3H]nicotine binding sites are associated with mammalian optic nerve terminals

Published online by Cambridge University Press:  02 June 2009

Glen T. Prusky  and
Max S. Cynader
Glen T. Prusky
Affiliation:
Departments of Psychology, Dalhousie University, Halifax, Nova Scotia
Max S. Cynader
Affiliation:
Departments of Psychology, Dalhousie University, Halifax, Nova Scotia Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia
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Abstract

The autoradiographic distribution of [3H]nicotine binding sites was examined in the superior colliculus in normal rats and cats, and in animals in which one or both eyes were removed. [3H]Nicotine binding sites in normal animals were densely concentrated in the superficial layers of the colliculus corresponding to the zone of termination of optic nerve fibers. Following bilateral enucleation, [3H]nicotine binding in the superficial collicular layers was drastically reduced. Unilateral enucleation markedly reduced [3H]nicotine binding sites in the colliculus contralateral to the removed eye, with little effect on the ipsilateral colliculus. These results provide further evidence that nicotinic acetylcholine receptors have a presynaptic location on optic tract terminals and may therefore modulate retinotectal transmission in both the rat and cat visual system.

Keywords

Nicotinic receptorAcetylcholineReceptor autoradiographySuperior colliculusRetinal afferentsVision
Type
Short Communications
Information
Visual Neuroscience , Volume 1 , Issue 2 , March 1988 , pp. 245 - 248
Copyright
Copyright © Cambridge University Press 1988

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