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Expression of calcium-binding proteins in cerebellar- and inferior olivary-projecting neurons in the nucleus lentiformis mesencephali of pigeons

Published online by Cambridge University Press:  01 May 2009

ANDREW N. IWANIUK ,
JANELLE M.P. PAKAN ,
CRISTIÁN GUTIÉRREZ-IBÁÑEZ  and
DOUGLAS R. WYLIE
ANDREW N. IWANIUK
Affiliation:
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
JANELLE M.P. PAKAN
Affiliation:
Department of Neuroscience, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
CRISTIÁN GUTIÉRREZ-IBÁÑEZ
Affiliation:
Department of Neuroscience, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
DOUGLAS R. WYLIE*
Affiliation:
Department of Neuroscience, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
*
*Address correspondence and reprint requests to: Douglas R. Wylie, Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9. E-mail: dwylie@ualberta.ca
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Abstract

In the avian brain, the optokinetic response is controlled by two retinal-recipient nuclei: the nucleus of the basal optic root (nBOR) of the accessory optic system and the pretectal nucleus lentiformis mesencephali (LM). Although considered sister nuclei because of their similar response properties and function, there are both similarities and differences with respect to efferent projections and neurochemistry. Both nBOR and LM project to the cerebellum (Cb) directly as mossy fibers but also indirectly via the inferior olive (IO). In a previous report, we showed that the cerebellar- and inferior olivary-projecting neurons in nBOR of pigeons differentially express the calcium-binding proteins calretinin (CR) and parvalbumin (PV). Both CR and PV are expressed in the somata of LM neurons, although the latter is not as prevalent, and whether expression of CR and PV reflects cerebellar and IO projections is not known. In this report, by combining retrograde neuronal tracing from the Cb and IO with fluorescent immunohistochemistry, we examined the expression of these calcium-binding proteins in the pigeon LM. Half (52%) of the cerebellar-projecting neurons were CR+ve, but only 15% were PV+ve. Almost all (>95%) these PV+ve cells also expressed CR. In contrast, few of the IO-projecting neurons expressed CR or PV (≤5%). This is strikingly similar to what we observed in nBOR and reveals that calcium-binding protein expression is concordant with projection patterns in two nuclei that share similar functions.

Keywords

CalretininParvalbuminPretectumCerebellumInferior oliveOptokinetic
Type
Brief Communication
Information
Visual Neuroscience , Volume 26 , Issue 3 , May 2009 , pp. 341 - 347
Copyright
Copyright © Cambridge University Press 2009

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