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Regulation of blood flow in diabetic retinopathy

Published online by Cambridge University Press:  20 July 2020

Amy R. Nippert  and
Eric A. Newman
Amy R. Nippert
Affiliation:
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
Eric A. Newman*
Affiliation:
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
*
*Address correspondence to: Eric A. Newman; E-mail: ean@umn.edu
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Abstract

Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands vary. This response, termed “functional hyperemia,” is disrupted in diabetic retinopathy. The reduction in functional hyperemia may result in retinal hypoxia and contribute to the development of retinopathy. This review will discuss the neurovascular coupling signaling mechanisms that generate the functional hyperemia response in the retina, the changes to neurovascular coupling that occur in diabetic retinopathy, possible treatments for restoring functional hyperemia and retinal oxygen levels, and changes to functional hyperemia that occur in the diabetic brain.

Keywords

Diabetic retinopathyneurovascular couplingblood flowhypoxianeurovascular unitMüller cells
Type
Review Article
Information
Visual Neuroscience , Volume 37 , 2020 , E004
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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