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Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55

Published online by Cambridge University Press:  18 March 2016

JOSEPH BOUSKILA ,
VANESSA HARRAR ,
PASHA JAVADI ,
CHRISTIAN CASANOVA ,
YOSHIO HIRABAYASHI Open the ORCID record for YOSHIO HIRABAYASHI [Opens in a new window] ,
ICHIRO MATSUO ,
JYUNPEI OHYAMA ,
JEAN-FRANÇOIS BOUCHARD Open the ORCID record for JEAN-FRANÇOIS BOUCHARD [Opens in a new window]  and
MAURICE PTITO
JOSEPH BOUSKILA
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada Biomedical Sciences, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
VANESSA HARRAR
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada
PASHA JAVADI
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada
CHRISTIAN CASANOVA
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada
YOSHIO HIRABAYASHI
Affiliation:
Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Japan
ICHIRO MATSUO
Affiliation:
Division of Molecular Science, Gunma University, Maebashi, Japan
JYUNPEI OHYAMA
Affiliation:
Division of Molecular Science, Gunma University, Maebashi, Japan
JEAN-FRANÇOIS BOUCHARD*
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada
MAURICE PTITO*
Affiliation:
School of Optometry, University of Montreal, Montreal, Quebec, Canada Neuropsychiatry Laboratory and Brainlab, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
*
*Address correspondence to: Maurice Ptito and Jean-François Bouchard, School of Optometry, room 260-7, 3744 Jean-Brillant, University of Montreal, Montreal, Quebec H3T 1P1, Canada. E-mail: maurice.ptito@umontreal.ca, jean-francois.bouchard@umontreal.ca
*Address correspondence to: Maurice Ptito and Jean-François Bouchard, School of Optometry, room 260-7, 3744 Jean-Brillant, University of Montreal, Montreal, Quebec H3T 1P1, Canada. E-mail: maurice.ptito@umontreal.ca, jean-francois.bouchard@umontreal.ca
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Abstract

The endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic CB1 and CB2 receptors. We have previously reported that the G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. To test this hypothesis, we recorded full-field electroretinograms (ERGs) after the intravitreal injection of the GPR55 agonist lysophosphatidylglucoside (LPG) or the selective GPR55 antagonist CID16020046 (CID), under light- and dark-adapted conditions. Thirteen vervet monkeys (Chlorocebus sabaeus) were used in this study: four controls (injected with the vehicle dimethyl sulfoxide, DMSO), four injected with LPG and five with CID. We analyzed amplitudes and latencies of the a-wave (photoreceptor responses) and the b-wave (rod and cone system responses) of the ERG. Our results showed that after injection of LPG, the amplitude of the scotopic b-wave was significantly higher, whereas after the injection of CID, it was significantly decreased, compared to the vehicle (DMSO). On the other hand, the a-wave amplitude, and the a-wave and b-wave latencies, of the scotopic ERG responses were not significantly affected by the injection of either compound. Furthermore, the photopic ERG waveforms were not affected by either drug. These results support the hypothesis that GPR55 plays an instrumental role in mediating scotopic vision.

Keywords

G protein-coupled receptor 55LPGCID16020046RetinaElectroretinogramMonkey
Type
Research Article
Information
Visual Neuroscience , Volume 33 , 2016 , E006
Copyright
Copyright © Cambridge University Press 2016 

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