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Neuromodulation of pigment movement in the RPE of normal and 6-OHDA-lesioned goldfish retinas

Published online by Cambridge University Press:  02 June 2009

Alexander K. Ball ,
William H. Baldridge  and
Timothy C. Fernback
Alexander K. Ball
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
William H. Baldridge
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
Timothy C. Fernback
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
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Abstract

The role of dopamine as the endogenous signal-initiating light-dependent changes in the distribution of pigment granules in goldfish retinal pigment epithelium was investigated. In normal retinas, light adaptation resulted in the dispersion of pigment granules. This effect of light was mimicked by the intraocular injection of dopamine or serotonin, which is thought to increase endogenous dopamine release, into dark-adapted eyes. The effect of light, dopamine, or serotonin on dark-adapted retinas was blocked by the dopamine receptor antagonists haloperidol and sulpiride. However, lesioning the endogenous source of retinal dopamine, by prior intraocular injection of 6-hydroxydopamine (6-OHDA), did not block the dispersion of pigment granules in light-adapted retinas. No significant differences in pigment dispersion were noted between unlesioned and lesioned light- or dark-adapted retinas. However, the effect of light on pigment dispersion was no longer blocked by haloperidol or sulpiride in 6-OHDA lesioned animals. Dopamine and serotonin mimicked the effect of light when injected into lesioned dark-adapted eyes, but their effects were also not blocked by haloperidol or sulpiride. These results suggest that dopamine, acting on D2 receptors, is sufficient to induce pigment migration in unlesioned animals. In 6-OHDA-lesioned animals, however, pigment migration is mediated by a receptor mechanism other than D2.

Keywords

Pigment movementPigment epithelium6-HydroxydopamineRetinaGoldfish
Type
Articles
Information
Visual Neuroscience , Volume 10 , Issue 3 , May 1993 , pp. 529 - 540
Copyright
Copyright © Cambridge University Press 1993

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