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A new interpretation of components in the ERG signals to sine wave luminance stimuli at different temporal frequencies and contrasts

Published online by Cambridge University Press:  26 August 2010

GOBINDA PANGENI ,
FOLKERT K. HORN  and
JAN KREMERS
GOBINDA PANGENI
Affiliation:
Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany
FOLKERT K. HORN
Affiliation:
Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany
JAN KREMERS*
Affiliation:
Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany School of Life Sciences, University of Bradford, Bradford, UK
*
*Address correspondence and reprint requests to: Jan Kremers, Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. E-mail: jan.kremers@uk-erlangen.de
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Abstract

Full-field electroretinograms were recorded from five normal human subjects using white light (mean luminance: 250 cd/m2) sine wave stimuli at different frequencies and contrasts. In agreement with previous studies, we found that the amplitude of the fundamental component displayed a dip at about 12 Hz, coinciding with a maximum in the second harmonic component, indicating frequency doubling of the responses. By including measurements at different contrasts, we were able to recognize two (sine-like and transient) response components. We found that the waveform of the transient response was relatively frequency independent. An algorithm to separate the two components was developed. The interaction between these two components can explain the frequency-doubled responses around 12 Hz. The sine-like component is more linear and prominent in the low-frequency region, whereas the transient seems to be more nonlinear and prominent in the high-frequency region.

Keywords

ElectroretinogramSine wave stimuliComponent analysisTemporal modulationLuminance contrast
Type
Research Articles
Information
Visual Neuroscience , Volume 27 , Issue 3-4 , July 2010 , pp. 79 - 90
Copyright
Copyright © Cambridge University Press 2010

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