Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-28T17:12:22.587Z Has data issue: false hasContentIssue false
  • English
  • Français

Poststimulus response characteristics of the human cone flicker electroretinogram

Published online by Cambridge University Press:  10 September 2013

SOWJANYA GOWRISANKARAN ,
J. JASON McANANY  and
KENNETH R. ALEXANDER
SOWJANYA GOWRISANKARAN
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois
J. JASON McANANY
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois Department of Psychology, University of Illinois at Chicago, Chicago, Illinois
KENNETH R. ALEXANDER*
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois Department of Psychology, University of Illinois at Chicago, Chicago, Illinois
*
*Address correspondence to: Kenneth R. Alexander, Department of Ophthalmology and Visual Sciences, 1855 W. Taylor Street, Chicago, IL 60612. E-mail: kennalex@uic.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

At certain temporal frequencies, the human cone flicker electroretinogram (ERG) contains multiple additional responses following the termination of a flicker train. The purpose of this study was to determine whether these poststimulus responses are a continuing response to the terminated flicker train or represent the oscillation of a resonant system. ERGs were recorded from 10 visually normal adults in response to full-field sinusoidally modulated flicker trains presented against a short-wavelength rod-saturating adapting field. The amplitude and timing properties of the poststimulus responses were evaluated within the context of a model of a second-order resonant system. At stimulus frequencies between 41.7 and 71.4 Hz, the majority of subjects showed at least three additional ERG responses following the termination of the flicker train. The interval between the poststimulus responses was approximately constant across stimulus frequency, with a mean of 14.4 ms, corresponding to a frequency of 69.4 Hz. The amplitude and timing characteristics of the poststimulus ERG responses were well described by an underdamped second-order system with a resonance frequency of 70.3 Hz. The observed poststimulus ERG responses may represent resonant oscillations of retinal ON bipolar cells, as has been proposed for electrophysiological recordings of poststimulus responses from retinal ganglion cells. However, further investigation is required to determine the types of retinal neurons involved in the generation of the poststimulus responses of the human flicker ERG.

Keywords

ERGConesFlickerTemporal frequencyResonance
Type
Research Articles
Information
Visual Neuroscience , Volume 30 , Issue 4 , July 2013 , pp. 147 - 152
Copyright
Copyright © Cambridge University Press 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Burrone, J. & Lagnado, L. (1997). Electrical resonance and Ca2+ influx in the synaptic terminal of depolarizing bipolar cells from the goldfish retina. The Journal of Physiology 505, 571–584.CrossRefGoogle ScholarPubMed
Gao, J., Schwartz, G., Berry, M.J. II. & Holmes, P. (2009). An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns. Network 20, 106–135.CrossRefGoogle ScholarPubMed
Marmor, M.F., Fulton, A.B., Holder, G.E., Miyake, Y., Brigell, M. & Bach, M. (2009). ISCEV standard for full-field clinical electroretinography (2008 update). Documenta Ophthalmologica. Advances in Ophthalmology 118, 69–77.CrossRefGoogle Scholar
McAnany, J.J. & Alexander, K.R. (2009). Is there an omitted stimulus response in the human cone flicker electroretinogram? Visual Neuroscience 26, 189–194.CrossRefGoogle ScholarPubMed
McAnany, J.J., Alexander, K.R., Kumar, N.M., Ying, H., Anastasakis, A. & Fishman, G.A. (2013). Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation. Ophthalmic Genetics 34, 167–173.CrossRefGoogle Scholar
Schwartz, G. & Berry, M.J. II. (2008). Sophisticated temporal pattern recognition in retinal ganglion cells. Journal of Neurophysiology 99, 1787–1798.CrossRefGoogle ScholarPubMed
Schwartz, G., Harris, R., Shrom, D. & Berry, M.J. II. (2007). Detection and prediction of periodic patterns by the retina. Nature Neuroscience 10, 552–554.CrossRefGoogle ScholarPubMed