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Rapid calcium-current kinetics in synaptic terminals of goldfish retinal bipolar neurons

Published online by Cambridge University Press:  01 November 1998

STEVEN MENNERICK  and
GARY MATTHEWS
STEVEN MENNERICK
Affiliation:
Department of Neurobiology and Behavior, State University of New York, Stony Brook
GARY MATTHEWS
Affiliation:
Department of Neurobiology and Behavior, State University of New York, Stony Brook
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Abstract

Onset and offset of calcium current in response to short, depolarizing voltage pulses were studied in giant synaptic terminals of goldfish bipolar neurons. Tail-current decays were extremely rapid (80 μs at −70 mV), and exponentially slowed at more positive repolarization potentials. The amplitude of tail current following voltage pulses varied with the pulse amplitude, according to a Bolzmann distribution with a V1/2 of −27.6 mV and a slope factor of 13.8 mV. When interpreted with a Hodgkin-Huxley model, calcium-current onset was best described by m2 kinetics and a time constant (τm) of 0.62 ms at −10 mV. The kinetics of calcium-current onset and offset are at least two- to threefold faster than those described in other native cells. Combined with other recent data, the results suggest that the rapid kinetics may participate in a fast signaling mode in the goldfish ON-center pathway.

Keywords

Calcium channelNeurotransmitterPresynapticActivationRetina
Type
Research Article
Information
Visual Neuroscience , Volume 15 , Issue 6 , November 1998 , pp. 1051 - 1056
Copyright
1998 Cambridge University Press

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