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The role of starburst amacrine cells in visual signal processing

Published online by Cambridge University Press:  06 February 2012

W.R. TAYLOR  and
R.G. SMITH
W.R. TAYLOR*
Affiliation:
Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
R.G. SMITH
Affiliation:
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania
*
*Address correspondence and reprint requests to: W.R. Taylor, Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwillger Blvd, Portland, OR 97239. E-mail: taylorw@ohsu.edu
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Abstract

Starburst amacrine cells (SBACs) within the adult mammalian retina provide the critical inhibition that underlies the receptive field properties of direction-selective ganglion cells (DSGCs). The SBACs generate direction-selective output of GABA that differentially inhibits the DSGCs. We review the biophysical mechanisms that produce directional GABA release from SBACs and test a network model that predicts the effects of reciprocal inhibition between adjacent SBACs. The results of the model simulations suggest that reciprocal inhibitory connections between closely spaced SBACs should be spatially selective, while connections between more widely spaced cells could be indiscriminate. SBACs were initially identified as cholinergic neurons and were subsequently shown to contain release both acetylcholine and GABA. While the role of the GABAergic transmission is well established, the role of the cholinergic transmission remains unclear.

Keywords

RetinaVisual systemDirection selectivityComputational modelGabaergic inhibition
Type
Review Article
Information
Visual Neuroscience , Volume 29 , Issue 1 , January 2012 , pp. 73 - 81
Copyright
Copyright © Cambridge University Press 2012

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