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Some visual and neurochemical correlates of refractive development

Published online by Cambridge University Press:  02 June 2009

Alan M. Laties  and
Richard A. Stone
Alan M. Laties
Affiliation:
Department of Ophthalmology, University of Pennsylvania School of MedicineScheie Eye Institute, Philadelphia
Richard A. Stone
Affiliation:
Department of Ophthalmology, University of Pennsylvania School of MedicineScheie Eye Institute, Philadelphia
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Abstract

Increasing evidence indicates that the retina takes part in the postnatal regulation of eye growth, functioning in this respect to minimize refractive error. The evidence derives both from clinical observations in man and from experiments in animals. The discovery that visual form deprivation leads to an axial overgrowth of the eye and to myopia has opened the way to many current research initiatives. Neurochemical and immunocytochemical experiments in chick and monkey suggest that definable retinal neurons participate in the regulatory pathway controlling eye growth. The most comprehensive data presently implicate dopaminergic amacrine cells. Other important issues to be addressed include the relevance of an intact connection to the central nervous system and the precise retinal mechanism by which eye growth is regulated.

Keywords

MyopiaDopamineEmmetropiaEye growthRefractive error
Type
Research Articles
Information
Visual Neuroscience , Volume 7 , Issue 1-2 , August 1991 , pp. 125 - 128
Copyright
Copyright © Cambridge University Press 1991

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