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Superior colliculus projections to target populations in the supraoculomotor area of the macaque monkey

Published online by Cambridge University Press:  11 November 2021

Paul J. May Open the ORCID record for Paul J. May [Opens in a new window] ,
Martin O. Bohlen ,
Eddie Perkins ,
Niping Wang  and
Susan Warren
Paul J. May*
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi
Martin O. Bohlen
Affiliation:
Department of Biomedical Engineering, Duke University, Durham, North Carolina
Eddie Perkins
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi
Niping Wang
Affiliation:
Department of Periodontics and Preventive Sciences, School of Dentistry, University of Mississippi Medical Center, Jackson, Mississippi
Susan Warren
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi
*
*Corresponding author: Paul J. May, email: pmay@umc.edu
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Abstract

A projection by the superior colliculus to the supraoculomotor area (SOA) located dorsal to the oculomotor complex was first described in 1978. This projection’s targets have yet to be identified, although the initial study suggested that vertical gaze motoneuron dendrites might receive this input. Defining the tectal targets is complicated by the fact the SOA contains a number of different cell populations. In the present study, we used anterograde tracers to characterize collicular axonal arbors and retrograde tracers to label prospective SOA target populations in macaque monkeys. Close associations were not found with either superior or medial rectus motoneurons whose axons supply singly innervated muscle fibers. S-group motoneurons, which supply superior rectus multiply innervated muscle fibers, appeared to receive a very minor input, but C-group motoneurons, which supply medial rectus multiply innervated muscle fibers, received no input. A number of labeled boutons were observed in close association with SOA neurons projecting to the spinal cord, or the reticular formation in the pons and medulla. These descending output neurons are presumed to be peptidergic cells within the centrally projecting Edinger–Westphal population. It is possible the collicular input provides a signaling function for neurons in this population that serve roles in either stress responses, or in eating and drinking behavior. Finally, a number of close associations were observed between tectal terminals and levator palpebrae superioris motoneurons, suggesting the possibility that the superior colliculus provides a modest direct input for raising the eyelids during upward saccades.

Keywords

oculomotorEdinger–Westphalurocortineyelidextraocular musclelevator palpebrae superioris
Type
Research Article
Information
Visual Neuroscience , Volume 38 , 2021 , E017
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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