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Time-dependent differential effects of cobalt ions on rod- and cone-driven responses in the isolated frog retina

Published online by Cambridge University Press:  02 June 2009

Cun-Jian Dong ,
John S. McReynolds  and
Hao-Hua Qian
Cun-Jian Dong
Affiliation:
Department of Physiology, University of Michigan, Ann Arbor Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
John S. McReynolds
Affiliation:
Department of Physiology, University of Michigan, Ann Arbor
Hao-Hua Qian
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
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Abstract

The effects of cobalt ions on 502-nm rod- and 575-nm cone-driven components of the b-wave of the electroretinogram were studied in the isolated frog retina. Addition of 100–150 μM cobalt initially caused a suppression of rod-driven responses and an enhancement of cone-driven responses. In the continued presence of cobalt, however, the rod-driven responses gradually recovered and the cone-driven responses became suppressed. These concentrations of cobalt had no effect on the rod- and cone-driven mass receptor potentials which were isolated in the presence of 4 mM glutamate. At higher concentrations of cobalt (1 mM or greater), both rod- and cone-driven b-wave responses were eliminated and there was no recovery in the continued presence of cobalt. The results suggest that cobalt has markedly different, time-dependent effects on signal transmission from rods and cones to second-order cells.

Keywords

RetinaCobaltSynaptic transmissionFrogRodCone
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 4 , April 1990 , pp. 359 - 365
Copyright
Copyright © Cambridge University Press 1990

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