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Published online by Cambridge University Press: 11 May 2015
The nucleoredoxin-like gene Nxnl1 (Txnl6) andits paralogue Nxnl2 encode the rod-derived cone viabilityfactors (RdCVF and RdCVF2), which increase the resistance to photooxidativedamage and have therapeutic potential for the survival of cones in retinitispigmentosa. In this study, the transcription of Nxnl genes wasinvestigated as a function of the day/night cycle in rats. The transcript levelsof Nxnl1 and Nxnl2 were seen to display dailyrhythms with steadily increasing values during the light phase and peakexpression around dark onset in preparations of whole retina, photoreceptorcells and—but only in regard to Nxnl1—inphotoreceptor-related pinealocytes. The cycling of Nxnl1 butnot that of Nxnl2 persisted in constant darkness in the retina.This suggests that daily regulation of Nxnl1 is driven by acircadian clock, whereas that of Nxnl2 is promoted byenvironmental light. The present data indicate clock- and light-dependentregulations of nucleoredoxin-like genes that may be part of a protective shieldagainst photooxidative damage.