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Application of linear regression to elucidate ileal inevitable flow and digestibility of amino acids and consequences for standardised digestibility system

Published online by Cambridge University Press:  26 May 2016

D.O. AKINDE
D.O. AKINDE*
Affiliation:
Amino Acids R&D, Fusion BioSystems GmbH, Deichstr. 4, 49393 Lohne, Germany
*
Corresponding author: David.akinde@fusionbiosystems.com
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Abstract

Several techniques are available solely applicable to the study of inevitable endogenous flow or the digestibility of amino acids (AAs) at the terminal ileum. But the linear regression technique combines these tasks in one simple and flexible platform extendable to multifactorial evaluation of feedstuffs, for example under alternating dietary and physiological conditions. There is evidence that the amount and composition of inevitable endogenous flows are not constant. Also their estimates are dependent on assay protocols and other laboratory conditions. This variability is a drawback to methodological precision of the current conventional standardised digestibility (cSID) system, where inevitable endogenous flow is applied to correct apparent digestibility. Notably cSID may suffer systematic errors when used to assay low AA ingredients or those high in AAs and in anti-nutrients, leading to underestimation or overestimation of standardised digestibility, respectively. Thus a standardised system not encumbered by the need to determine inevitable flow should offer more latitude for precision. The latter approach is followed in linear regression. The linear regression approach is based on validated hypotheses both mathematical and physiological, which enable its ordinate intercept and slope respectively to be considered as inevitable endogenous flow and standardised digestibility. The literature shows that this method does not penalise ingredients low in AAs as its estimates are independent of dietary crude protein level; and it is efficient to determine standardised digestibility in feedstuffs which elevate the production of specific endogenous ileal AA flow. Nevertheless work remains to be done to standardise its protocols to improve comparability of data across investigations. It can be concluded that linear regression is a reliable path for routine determination of inevitable endogenous flow and standardised AA digestibility at the end of the ileum.

Keywords

linear regressionileal inevitable flowamino acid digestibilitypoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 72 , Issue 2 , June 2016 , pp. 245 - 264
Copyright
Copyright © World's Poultry Science Association 2016 

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References

ADEDOKUN, S.A., LILBURN, M.S., PARSONS, C.M., ADEOLA, O. and APPLEGATE, T.J. (2007a) Endogenous amino acid flow in broiler chicks is affected by the age of birds and method of estimation. Poultry Science 86: 2590-2597 2007.Google Scholar
ADEDOKUN, S.A., PARSONS, C.M., LILBURN, M.S., ADEOLA, O. and APPLEGATE, T.J. (2007b) Standardised ileal amino acid digestibility of meat and bone meal from different sources in broiler chicks and turkey poults using a nitrogen-free or casein diet. Poultry Science 86: 2598-2607.Google Scholar
ADEDOKUN, S.A., ADEOLA, O., PARSONS, C.M., LILBURN, M.S. and APPLEGATE, T.J. (2011) Review: Factors affecting endogenous amino acid flow in chickens and the need for consistency in methodology. Poultry Science 90: 1737-1748.Google Scholar
AKINDE, O.A. (2007) Studies on inevitable losses of amino acids and nitrogen in the Pekin duck and their consequences for maintenance nitrogen requirement. Ph. D. Thesis, University of Halle-Wittenberg.Google Scholar
AKINDE, O.A., KLUTH, H. and RODEHUTSCORD, M. (2010) Studies on the inevitable losses of nitrogen in Pekin ducks. Archiv für Geflügelkunde 74: 233-239.Google Scholar
AKINDE, O.A., KLUTH, H. and RODEHUTSCORD, M. (2011) Inevitable endogenous amino acid and CP losses in the terminal ileum of Pekin ducks as affected by cellulose supplementation. Poultry Science 90 (E-Supplement 1): 133.Google Scholar
AKINDE, D.O. (2014a) Amino acid efficiency with dietary glycine supplementation: Part 1. World's Poultry Science Journal 70: 461-474.Google Scholar
AKINDE, D.O. (2014b) . Amino acid efficiency with dietary glycine supplementation: Part 2. World's Poultry Science Journal 70: 575-584.Google Scholar
BIELORAI, R., IOSIF, B. and NEUMARK, H. (1985) Nitrogen absorption and endogenous nitrogen along the intestinal tract of chicks. Journal of Nutrition 115: 568-572.Google Scholar
BIELORAI, R. and IOSIF, B. (1987) Amino acid absorption and endogenous amino acids in the lower ileum and excreta of chicks. Journal of Nutrition 117: 1459-1462.Google Scholar
COWIESON, A.J., BEDFORD, M.R., SELLE, P.H. and RAVINDRAN, V. (2009) Phytate and microbial phytase: implications for endogenous nitrogen losses and nutrient availability. World's Poultry Science Journal 65: 401-418.Google Scholar
DORIGAM, J.C.P., SAKOMURA, N.K., LIMA, M.B., SARCINELLI, M.F. and SUZUKI, R.M. (2015) Establishing an amino acid pattern and ideal ratio for maintenance of poultry by deletion method. Proceedings of the 20th European Symposium on Poultry Nutrition, Prague. Full papers pp. 501-512.Google Scholar
EDWARDS, H.M., III, FERNANDEZ, S.R. and BAKER, D.H. (1999) Maintenance lysine requirement and efficiency of using lysine for accretion of whole-body lysine and protein in young chicks. Poultry Science 78: 1412-1417.Google Scholar
FAN, M.Z., SAUER, W.C., HARDIN, R.T. and LIEN, K.A. (1994) Determination of apparent ileal amino acid digestibility in pigs: Effect of dietary amino acid level. Journal of Animal Science 72: 2851-2859.Google Scholar
FAN, M.Z., SAUER, W.C. and MCBURNEY, M.I. (1995) Estimation by regression analysis of endogenous amino acid levels in digesta collected from the distal ileum of pigs. Journal of Animal Science 73: 2319-2328.Google Scholar
FERNANDEZ-FIGARES, I., NIETO, R., PRIETO, C. and AGUILERA, J.F. (2002) Estimation of endogenous amino acid losses in growing chickens given soya-bean meal supplemented or not with DL-methionine. Animal Science 75: 415-426.Google Scholar
GANZER, C., KLUTH, H. and RODEHUTSCORD, M. (2006) Effect of including free amino acids in the basal diet on precaecal amino acid digestibility of test proteins determined by regression analysis in broilers. Proceedings of the Society of Nutrition Physiology 15: 31.Google Scholar
GfE [GESELLSCHAFT FÜR ERNÄHRUNGSPHYSIOLOGIE]. (2002) Mitteilungen des ausschusses für bedarfsnormen: Bestimmung der praecaecalen verdaulichkeit von aminosäuren beim schwein - empfehlung zur standardisierten versuchsdurchführung (estimation of the precaecal digestibility of amino acids in pigs: recommendations for a standardised experimental procedure). Proceedings of the Society of Nutrition Physiology 11: 233-245.Google Scholar
GOLIAN, A., GUENTER, W., HOEHLER, D., JAHANIAN, H. and NYACHOTI, C.M. (2008) Comparison of various methods for endogenous ileal amino acid flow determination in broiler chickens. Poultry Science 87: 706-712.Google Scholar
JANSMAN, A.J.M., SMINK, W., VAN LEEUWEN, P. and RADEMACHER, M. (2002) Evaluation through literature data of the amount and amino acid composition of basal endogenous crude protein at the terminal ileum of pigs. Animal Feed Science and Technology 98: 49-60.Google Scholar
JHA, R., HTOO, J.K., YOUNG, M.G., BELTRANENA, E. and ZIJLSTRA, R.T. (2013) Effects of increasing co-product inclusion and reducing dietary protein on growth performance, carcass characteristics, and jowl fatty acid profile of growing–finishing pigs. Journal of Animal Science 91: 2178-2191.Google Scholar
KADIM, I.T., MOUGHAN, P.J. and RAVINDRAN, V. (2002) Ileal amino acid digestibility assay for the growing meat chicken-comparison of ileal and excreta amino acid digestibility in the chicken. British Poultry Science 44: 588-597.Google Scholar
KHAJALI, F. and SLOMINSKI, B.A. (2012) Factors that affect the nutritive value of canola meal for poultry. Poultry Science 91: 2564-2575.Google Scholar
KLUTH, H., MANTEI, M., ELWERT, C. and RODEHUTSCORD, M. (2005) Variation in precaecal amino acid and energy digestibility between pea (Pisum sativum) cultivars determined using a linear regression approach. British Poultry Science 46: 325-332.Google Scholar
KONG, C. and ADEOLA, O. (2013a) Ileal endogenous amino acid flow response to nitrogen-free diets with differing ratios of corn starch to dextrose in broiler chickens. Poultry Science 92: 1276-1282.Google Scholar
KONG, C. and ADEOLA, O. (2013b) Comparative amino acid digestibility for broiler chickens and white Pekin ducks. Poultry Science 92: 2367-2374.Google Scholar
KONG, C. and ADEOLA, O. (2013c) Additivity of amino acid digestibility in corn and soybean meal for broiler chickens and white Pekin ducks. Poultry Science 92: 2381-2388.Google Scholar
KOZŁOWSKI, K., HELMBRECHT, A., LEMME, A., JANKOWSKI, J. and JEROCH, H. (2011) Standardised ileal digestibility of amino acids from high-protein feedstuffs for growing turkeys – a preliminary study. Archiv für Geflügelkunde 75: 185-190.Google Scholar
LEMME, A., RAVINDRAN, V. and BRYDEN, W.L. (2004) Ileal digestibility of amino acids in feed ingredients for broilers. World's Poultry Science Journal 60: 423-437.Google Scholar
MACK, S., BERCOVICI, D., DE GROOTE, G., LECLERCQ, B., LIPPENS, M., PACK, M., SCHUTTE, J.B. and VAN CAUWENBERGHE, S. (1999) Ideal amino acid profile and dietary lysine specification for broiler chickens of 20 to 40 days of age. British Poultry Science 40: 257-265.Google Scholar
MITCHELL, H.H. and BERT, M.H. (1954) The determination of metabolic fecal nitrogen. Journal of Nutrition 52: 483-497.Google Scholar
MOUGHAN, P.J. and FULLER, M.F. (2003) Modelling amino acid metabolism and the estimation of amino acid requirements, in: D'MELLO, J.P.F. (Ed) 2 ed., Amino Acids in Animal Nutrition, pp. 187-202 (CAB international, Oxon, UK).Google Scholar
NYACHOTI, C.M., DE LANGE, C.F.M., MCBRIDE, B.W. and SCHULZE, H. (1997) Significance of endogenous gut nitrogen losses in the nutrition of growing pigs: A review. Canadian Journal of Animal Science 77: 149-163.Google Scholar
OWENS, F.N. and PETTIGREW, J.E. (1989) Subdividing amino acid requirements into portions for maintenance and growth, in: FRIEDMAN, M. (Ed) Absorption and utilisation of amino acids, pp. 15-30 (CRC Press, Boca Raton).Google Scholar
PATZELT, C. and SCHILTZ, E. (1984) Conversion of proglucagon in pancreatic alpha cells: The major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences. Proceedings of the National Academy of Sciences of the United States of America 81: 5007-5011.Google Scholar
RAVINDRAN, V. and BRYDEN, W.L. (1999) Amino acid availability in poultry - in vitro and in vivo measurements. Australian Journal of Agricultural Research 50: 889-908.Google Scholar
RAVINDRAN, V., HEW, L.I., RAVINDRAN, G. and BRYDEN, W.L. (2004) Endogenous amino acid flow in the avian ileum: Quantification using three techniques. British Journal of Nutrition 92: 217-223.Google Scholar
REZVANI, M., KLUTH, H., BULANG, M. and RODEHUTSCORD, M. (2012) Variation in amino acid digestibility of rapeseed meal studied in caecectomised laying hens and relationship with chemical constituents. British Poultry Science 53: 665-674.Google Scholar
RODEHUTSCORD, M., KAPOCIUS, M., TIMMLER, R. and DIECKMANN, A. (2004) Linear regression approach to study amino acid digestibility in broiler chickens. British Poultry Science 45: 85-92.Google Scholar
RUTHERFURD, S.M., CHUNG, T.K., MOREL, P.C.H. and MOUGHAN, P.J. (2004) Effect of microbial phytase on ileal digestibility of phytate phosphorus, total phosphorus, and amino acids in a low-phosphorus diet for broilers. Poultry Science 83: 61-68.Google Scholar
SHORT, F.J., WISEMAN, J. and BOORMANN, K.N. (1999) Application of a method to determine ileal digestibility in broilers of amino acids in wheat. Animal Feed Science Technology 79: 195-209.Google Scholar
SIRIWAN, P., BRYDEN, W.L., MOLLAH, Y. and ANNISON, E.F. (1993) Measurement of endogenous amino acid losses in poultry. British Poultry Science 34: 939-949.Google Scholar
SOLEIMANI, A.F., KASIM, A., ALIMON, A.R., MEIMANDIPOUR, A. and ZULKIFLI, I. (2010) Ileal endogenous amino acid flow of broiler chickens under high ambient temperature. Animal Physiology and Animal Nutrition (Berlin) 94: 641-647.Google Scholar
SPINDLER, H.K., MOSENTHIN, R. and EKLUND, M. (2014) Evaluation through literature data on standardised ileal digestibility and basal ileal endogenous loss of amino acids associated with barley in pigs. Animal 8: 1603-1611.Google Scholar
STEIN, H.H., SÈVE, B., FULLER, M.F., MOUGHAN, P.J. and DE LANGE, C.F. (2007) Committee on Terminology to Report AA Bioavailability and Digestibility. Invited review: Amino acid bioavailability and digestibility in pig feed ingredients: terminology and application. Journal of Animal Science 85: 172-180.Google Scholar
SZCZUREK, W. (2009) Standardised ileal digestibility of amino acids from several cereal grains and protein-rich feedstuffs in broiler chickens at the age of 30 days. Journal of Animal and Feed Sciences 18: 662-676.Google Scholar