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Effects of retinoids on immune responses in birds

Published online by Cambridge University Press:  18 September 2007

Aharon Friedman  and
David Sklan
Aharon Friedman
Affiliation:
Department of Animal Sciences, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot, Israel
David Sklan
Affiliation:
Department of Animal Sciences, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot, Israel
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Abstract

Vitamin A is an essential nutrient that has an influence on immune responses in birds. Both low and high vitamin A intakes result in impaired immune responses. Low dietary vitamin A has been shown to cause reduced antibody production, defective T-cell responses and reduced phagocytosis, and decreased resistance to infection by bacterial and viral pathogens and protozoan enteropathogens. Enhanced immune responses can be elicited by high, but not excessive, dosages of vitamin A. Optimum immune responses in growing chicks and turkeys were obtained with vitamin A intakes that were 3–10 fold higher than NRC recommended levels.

Keywords

Chicksdomestic fowlimmune responseturkeysvitamin A
Type
Research Article
Information
World's Poultry Science Journal , Volume 53 , Issue 2 , June 1997 , pp. 185 - 195
Copyright
Copyright © Cambridge University Press 1997

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References

Abels, J.C., Gorham, A.T., Pack, G.T. and Rhoads, C.P. (1941) Metabolic studies in patients with cancer of the gastrointestinal tract I. Plasma vitamin A levels in patients with malignant neoplastic disease, particularly of the gastrointestinal tract. Journal of Clinical Investigation 20: 749–764CrossRefGoogle Scholar
Augustine, P.C. and Ruff, M.D. (1983) Changes in carotenoid and vitamin A levels in young turkeys infected with Eimeria meleagrimitis or E. adenoeides. Avian Diseases 27: 963–971CrossRefGoogle ScholarPubMed
Aydelotte, M.B. (1963) Vitamin A deficiency in chickens. British Journal of Nutrition 17: 205–211CrossRefGoogle ScholarPubMed
Bang, F.B., Bang, B.G. and Foard, M. (1975) Acute Newcastle disease virus infection of the upper respiratory tract of the chicken. II. The effects of diets deficient in vitamin A on the pathogenesis of the infection. American Journal of Pathology 79: 417–424Google Scholar
BEDO, G., Santisteban, P. and Aranda, A. (1989) Retinoic acid regulates growth hormone gene expression. Nature 339: 231–234CrossRefGoogle ScholarPubMed
Blomhoff, R., Green, M.H., Green, J.B., Berg, T., Norum, K.R. (1991) Vitamin A metabolism: new perspectives on absorption, transport and storage. Physiology Reviews 71: 951–990CrossRefGoogle ScholarPubMed
Bondi, A. and Sklan, D. (1984) Vitamin A and carotene in animal nutrition. Progress in Food and Nutrition Science 8: 165–191Google ScholarPubMed
Boyd, EM. and Edwards, H.M. (1962) The effect of vitamin A on the course of Mycoplasma infection in chicks. Poultry Science 41: 750–754CrossRefGoogle Scholar
Chambon, P., Zelent, A., Petkovich, M., Mendelsohn, C., Leroy, P., Krust, A., Kastner, P. and Brand, N. (1991) The family of retinoic acid nuclear receptors. In: Retinoids: 10 Years On (Ed. Saurat, J-H.), Karger, Basel pp. 10–27Google Scholar
Damm, K., Thompson, C.C. and Evans, R.M. (1989) Protein encoded by v-erbA functions as a thyroid hormone acceptor antagonist. Nature 339: 593–597CrossRefGoogle Scholar
Darip, M.D., Sirisinha, S. and Lamb, A. (1979) Effect of vitamin A deficiency on the susceptibility of rats to Angiostrongylus cantonensis. Proceedings of the Society for Experimental Biology and Medicine 161: 600–604CrossRefGoogle ScholarPubMed
Davis, C.Y. and Sell, J.L. (1989) Immunoglobulin concentrations in serum and tissues of vitamin A-deficient broiler chicks after Newcastle disease virus vaccination. Poultry Science 65: 136–144CrossRefGoogle Scholar
Deluca, L.M., Shumacher, M. and Nelson, D.P. (1971) Localisation of the retinol dependent fucose-glycopeptide in the goblet cell of the rat small intestine. Journal of Biological Chemistry 246: 5762–5766CrossRefGoogle Scholar
Dingle, J.T. (1968) Vacuoles, vesicles and lysosomes. British Medical Bulletin 24: 141–145CrossRefGoogle ScholarPubMed
Dolle, P., Roperte, E., Kastner, P., Petkovitch, M., Stoner, C.M., Gudas, L.J. and Chambon, P. (1989) Differential expression of genes encoding, α, β, and γ retinoic acid receptors and cRABP in the developing limbs of the mouse. Nature 342: 702–705CrossRefGoogle ScholarPubMed
Dhur, A., Galan, P. and Hercberg, S. (1991) Vitamin A deficiency and immunity. Journal of Clinical and Biochemical Nutrition 11: 1–19CrossRefGoogle Scholar
Eaton, H.D. (1969) Chronic bovine hypo and hypervitaminosis A and cerebrospinal fluid pressure. American Journal of Clinical Nutrition 22: 1070–1080CrossRefGoogle ScholarPubMed
Fell, H.B. and Mellanby, E. (1952) The effect of hypervitaminosis A on embryonic limb bones cultivated in vitro. Journal of Physiology 116: 320–349CrossRefGoogle ScholarPubMed
Fletcher, R.A. (1971) Effects of vitamin A deficiency on the pituitary-gonad axis of the California quail (Lophortyx californicus). Journal of Experimental Zoology 176: 25–29CrossRefGoogle ScholarPubMed
Friedman, A. (1991) Induction of immune response to protein antigens by subcutaneous co-injection with water miscible vitamin A derivatives. Vaccine 9: 122–128CrossRefGoogle ScholarPubMed
Friedman, A. and Sklan, D. (1989a) Impaired T-lymphocyte immune response in vitamin A depleted rats and chicks. British Journal of Nutrition 62: 439–449Google Scholar
Friedman, A. and Sklan, D. (1989b) Antigen specific immune response impairment in the chick as influenced by vitamin A nutrition. Journal of Nutrition 119: 790–795CrossRefGoogle Scholar
Friedman, A. and Sklan, D. (1992) Adjuvant properties of vitamin A and derivatives influenced by form of delivery. Journal of Nutritional Immunology 1: 65–73Google Scholar
Friedman, A. and Sklan, D. (1993) Vitamin A and immunity. In: Nutrition and Immunology. Vol.8. Human Nutrition: a Comprehensive Treatise (Eds Alfin-Slater, R.B. and Kritchevsky, D.), Plenum, New York pp. 197–216CrossRefGoogle Scholar
Friedman, A., Meidovsky, A., Leitner, G. and Sklan, D. (1991) Decreased resistance and immune response to E. coli infection in chicks with low and high intakes of vitamin A. Journal of Nutrition 121: 395–400CrossRefGoogle Scholar
Fujimaki, I. (1926) Formation of carcinoma in albino rats fed on deficient diets. Journal of Cancer Research 10: 469–477Google Scholar
Giguere, V., Ong, E.S., Segui, P. and Evans, R.M. (1987) Identification of the receptor for the morphogen retinoic acid. Nature 330: 624–629CrossRefGoogle ScholarPubMed
Glass, C.K., Lipkin, S.M., Devary, O.V. and Rosenfeld, M.G. (1989) Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor. Cell 59: 697–708CrossRefGoogle ScholarPubMed
Graupner, G., Wills, K.N., Tzukerman, M., Zhang, X.K. and Pfahl, M. (1989) Dual regulatory role for thyroid-hormone receptors allows control of retinoic acid receptor activity. Nature 340: 653–656CrossRefGoogle ScholarPubMed
Green, H.N. and Mellanby, E. (1928) Vitamin A as an anti-infective agent. British Medical Journal 2: 691–696CrossRefGoogle ScholarPubMed
Halevy, O., Arazi, Y., Melamed, D., Friedman, A. and Sklan, D. (1993) Retinoic acid receptor-α gene expression is modulated by dietary vitamin A and by retinoic acid in chicken ‘I’ lymphocytes. Journal of Nutrition 124: 2139–2146CrossRefGoogle Scholar
Hall, W.C., Damjanou, I., Nielsen, S.W., VAN DER Heide, L. and Eaton, H.D. (1980) Testicular changes of acute vitamin A deficiency of cockerels. American Journal of Veterimry Research 41: 586–592Google Scholar
Hatchigian, E.A., Santos, J.I., Broitman, S.A. and Vitale, J.J. (1989) Vitamin A supplementation improves macrophage function and bacterial clearance during experimental Salmonella infection. Proceedings of the Society for Experimental Biology and Medicine 191: 47–54CrossRefGoogle ScholarPubMed
Howell, J.McC. and Thompson, J.N. (1967) Lesions associated with the development of ataxia in vitamin A deficient birds. British Journal of Nutrition 21: 741–748CrossRefGoogle Scholar
Kriz, H. and Holman, J. (1969) Histology of onset of skin changes in hypervitaminosis A in chickens. International Ionrnal of Vitamin Research 39: 3–7Google Scholar
Krust, A., Kastner, P., Petkovich, M., Zelent, A. and Chambon, P. (1989) A third human retinoic acid receptor. Proceedings of the National Academy of Sciences USA 56: 5310–5314CrossRefGoogle Scholar
Lee, L.F. and Bacon, L.D. (1983) Ontogeny and line differences in the mitogenic response of chicken lymphocytes. Poultry Science 62: 579–584CrossRefGoogle ScholarPubMed
Leutskaya, Z.K. and Fais, D. (1977) Antibody synthesis stimulation by vitamin A in chickens. Biochimica et Biophysica Acta 475: 207–216Google Scholar
Lippman, S.M. and Meyskens, EL. (1988) Vitamin A derivatives in the prevention and treatment of human cancer. Journal of American Clinical Nutrition 7: 269–284Google ScholarPubMed
Lopen, G.A., Phillips, R.W. and Nockels, C.F. (1973) Body water kinetics in vitamin A deficient chickens. Proceedings of the Society for Experimental Biology and Medicine 144: 54Google Scholar
Lotan, R. (1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochimica et Biophysica Acta 605: 33–91Google ScholarPubMed
Madden, M., Ong, D.E., Summerbell, D. and Chytil, F. (1988) Spatial distribution of cellular binding protein to retinoic acid in the chick limb bud. Nature 335: 733–735CrossRefGoogle Scholar
Mallia, A.K., Smith, J.E. and Goodman, D.S. (1975) Metabolism of retinol binding protein and vitamin A in hypervitaminosis A in the rat. Journal of Lipid Research 16: 180–188Google Scholar
Merrill, A.H. Jr., Foltz, A.T. and Mccormick, D.B. (1991) Vitamins and cancer. In: Cancer and Nutrition (Eds Alfin-Slater, R.B. and Kritchevsky, D.), Plenum, New York pp. 261–320Google Scholar
Mitrovic, M., Marusich, W.L. and Deutsch, D. (1969) Effect of high level supplemental vitamin A on avian leukosis agents in chicks. Poultry Science 48: 1633–1636CrossRefGoogle ScholarPubMed
Napoli, J.L. and Race, K.R. (1988) Biogenesis of retinoic acid from β-carotene. Differences between the metabolism of β-carotene and retinal. Journal of Biological Chemistry 263: 17372–17377Google Scholar
NRC (1994) Nutrient Requirements for Poultry. 9th ed. National Academy Press, Washington, DCGoogle Scholar
Nockels, C.F., Ewing, D.L., Phetteplace, H., Ritacco, K.A. and Mero, K.W. (1984) Hypothyroidism: an early sign of vitamin A deficiency in chickens. Journal of Nutrition 114: 1733–1737CrossRefGoogle ScholarPubMed
Ongsakul, M., Sirisinha, S. and Lamb, A. (1985) Impaired clearance of bacteria and phagocytic activity in vitamin A deficient rats. Proceedings of the Society for Experimental Biology and Medicine 178: 204–208CrossRefGoogle ScholarPubMed
Pasatiempo, M.G., Bowman, T.A., Taylor, C.E. and Ross, C.A. (1989) Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III). American Journal of Clinical Nutrition 49: 501–510Google Scholar
Petkovitch, M., Brand, N.J., Krust, A. and Chambon, P. (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444–450Google Scholar
Rikhter, G. and Wiesner, J. (1987) Relationship between vitamin A supply of chicks and their susceptibility to field isolates of Eimevia tenella. Monatshefte fur Veterinarmedizin 42: 895–896Google Scholar
Rikhter, G., Okhrimenko, K. and Vizner, I. (1989) Effect of dietary protein and vitamin A levels on the resistance of chickens to coccidiosis. Plitsevodstvo 10: 41–43Google Scholar
Serman, V. and Mazija, H. (1985) Effects of nutrition on the strength of acquired immunity against Newcastle disease. IV. Role of vitamin A. Veterinarski Arhiv 55: 1–8Google Scholar
Shapiro, P.E. and Edelson, R.L. (1985) Effects of retinoids on the immune system. In: Retinoids: New Trends in Research and Thernpy (Ed. Saurat, J.), Karger, Basel pp. 225–235Google Scholar
Sherr, E., Adelman, D.C., Saxon, A., Gilly, M., Wall, R. and Sidell, N. (1988) Retinoic acid induces the differentiation of B cell hybridomas from patients with common variable immunodeficiency. Journal of Experimental Medicine 168: 55–71CrossRefGoogle ScholarPubMed
Sidell, N. and Ramsdell, F. (1988) Retinoic acid upregulates interleukin-2 receptors on activated human thymocytes. Cellular Immunology 115: 299–309Google Scholar
Sidell, N., Taga, T., Hirano, T., Kishimoto, T. and Saxon, A. (1991) Retinoic acid induced growth inhibition of a human myeloma cell line via down regulation of IL-6 receptors. Journal of Immunology 146: 3809–3814CrossRefGoogle ScholarPubMed
Sijtsma, S.R., West, C.E., Rombout, J.H.W.M., Van Der Zijpp, A.J. and Van Der Zijpp, A.J. (1989a) The interaction between vitamin A status and Newcastle disease virus infection in chickens. Journal of Nutrition 119: 932–939CrossRefGoogle ScholarPubMed
Sijtsma, S.R., West, C.E., Rombout, J.H.W.M., Van Der Zijpp, A.J. and Van Der Zijpp, A.J. (1989b) Effect of Newcastle disease virus infection on vitamin A metabolism in chickens. Journal of Nutrition 119: 940–947Google Scholar
Sijtsma, S.R., Rombout, J.H.W.M., West, C.E., Van Der Zijpp, A.J. and Van Der Zijpp, A.J. (1990) Vitamin A deficiency impairs cytotoxic T lymphocyte activity in Newcastle disease virus infected chickens. Veterinary Immunology and Pathology 26: 191–201CrossRefGoogle ScholarPubMed
Sijtsma, S.R., Rombout, J.H.W.M., Dohmen, M.J.W., West, C.E. and Van Der Zijpp, A.J. (1991) Effect of vitamin A deficiency on the activity of macrophages in Newcastle disease virus infected chickens. Veterinary Immunology and Immunopathology 27: 17–27Google Scholar
Singh, S.P. and Donovan, G.A. (1973) A relationship between coccidiosis and dietary vitamin A levels in chickens. Poultry Science 52: 1295–1301Google Scholar
Singh, M. and Singh, V.M. (1978) Fatty liver in hypervitaminosis A; synthesis and release of hepatic triglycerides. American Journal of Physiology 234: E511–514Google ScholarPubMed
Sklan, D. (1983) Vitamin A absorption and metabolism in the chick: response to high dietary intake and tocopherol. British Journal of Nutrition 50: 401–407CrossRefGoogle Scholar
Sklan, D. and Donoghue, S. (1982) Vitamin A response to high dietary vitamin A in the chick. Journal of Nutrition 112: 759–765CrossRefGoogle ScholarPubMed
Sklan, D., Melamed, D. and Friedman, A. (1994) The effect of varying levels of dietary vitamin A on immune response in the chick. Poultry Science 73: 843–847CrossRefGoogle ScholarPubMed
Sklan, D., Melamed, D. and Friedman, A. (1995) The effect of varying dietary concentrations of vitamin A on immune response in the turkey. British Poultry Science 36: 385–392Google Scholar
Smith, J.E., Milch, P.O., Muto, Y. and Goodman, D.S. (1973) The plasma transport and metabolism of retinoic acid in the rat. Biochemical Journal 132: 821–827CrossRefGoogle ScholarPubMed
Thaller, C. and Eichele, G. (1987) The identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327: 625–628CrossRefGoogle ScholarPubMed
Tengerdy, R.P. and Nockels, C.F. (1975) Vitamin E or vitamin A protects chickens against Escherichia coli infection. Poultry Science 54: 1292–1296Google Scholar
Umesono, K., Giguere, V., Glass, C.K., Rosenfeld, M.G. and Evans, R.M. (1988) Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature 336: 262–265CrossRefGoogle ScholarPubMed
Vasios, G.W., Gold, J.D., Petkovich, M., Chambon, P. and Gudas, L.J. (1989) A retinoic acid responsive element is present in the 5'-flanking region of the laminin B1 gene. Proceedings of the National Academy of Sciences USA 86: 9099–9013CrossRefGoogle ScholarPubMed
Wald, G. (1968) The molecular basis of visual excitation. Nature 291: 800–807Google Scholar
Watson, R.R. and Rybski, J.A. (1988) Immunological response modification by vitamin A and other retinoids. In: Nutrition and Immunology, Alan Liss, New York pp. 87–99Google Scholar
WestC,E. C,E., Rombout, J.H.W.M., Van Der Zijpp, A.J. and Sijtsma, S.R. (1991) Proceedings of the Nutrition Society 50: 251–262Google Scholar
Wolbach, S.B. (1947) Vitamin A deficiency and excess in relation to bone growth. Journal of Bone and Joint Surgery 29: 171–192Google Scholar
Wolbach, S.B. and Howe, P.R. (1925) Tissue changes following deprivation of fat soluble A vitamin. Journal of Experimental Medicine 42: 753–777CrossRefGoogle ScholarPubMed
Wolf, G. (1990) Recent progress in vitamin A research: nuclear retinoic acid receptors and their interaction with gene elements. Journal of Nutritional Biochemistry 1: 284–289Google Scholar
Wolf, G. (1991) The intracellular vitamin A binding proteins: an overview of their functions. Nutrition Reviews 49: 1–12Google Scholar
Yamamoto, M., Kitano, T., Oma, M., Hiyama, Y., Yumoto, S. and Matsui, M. (1988) Supplemental effects of retinoids on immune function in vitamin A deficient rats. Nutrition Research 8: 529–538Google Scholar
Zelent, A., Krust, A., Petkovich, M., Kastner, P. and Chambon, P. (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 339: 714–717Google Scholar