Hostname: page-component-745bb68f8f-lrblm Total loading time: 0 Render date: 2025-01-30T15:23:06.818Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunomodulating effects of vitamin E in broilers

Published online by Cambridge University Press:  21 February 2012

R.U. KHAN ,
Z.U. RAHMAN ,
Z. NIKOUSEFAT ,
M. JAVDANI ,
V. TUFARELLI ,
C. DARIO ,
M. SELVAGGI  and
V. LAUDADIO
R.U. KHAN*
Affiliation:
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Z.U. RAHMAN
Affiliation:
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Z. NIKOUSEFAT
Affiliation:
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Iran
M. JAVDANI
Affiliation:
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Iran
V. TUFARELLI
Affiliation:
Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, 700100 Valenzano, Bari, Italy
C. DARIO
Affiliation:
Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, 700100 Valenzano, Bari, Italy
M. SELVAGGI
Affiliation:
Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, 700100 Valenzano, Bari, Italy
V. LAUDADIO
Affiliation:
Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, 700100 Valenzano, Bari, Italy
*
Corresponding author: rifatullahkhhan@gmail.com
Get access

Abstract

Modern commercial broilers appear to have compromised immunocompetence, higher mortality and lower resistance to stressors. To overcome these, dietary manipulation seems to be the easiest approach, and this has been supported by research investigations conducted over the last few decades. The goal of enhancing the immune system of broilers is laudable for both economic and welfare reasons. Vitamin E (VE) is now well accepted as nature's most effective lipid-soluble, chain-breaking antioxidant. This antioxidant vitamin has been shown to improve both cell-mediated and humoral immunity in broiler chicks. However, the effect of this vitamin depends upon dose, age and genetics of the broiler chicks. Several mechanisms have been postulated for the beneficial effects of this vitamin. In this review, several aspects of the immunomodulatory effects of VE are reviewed.

Keywords

broilersimmunityvitamin E
Type
Review Article
Information
World's Poultry Science Journal , Volume 68 , Issue 1 , March 2012 , pp. 31 - 40
Copyright
Copyright © World's Poultry Science Association 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

BOA-AMPONSEM, K., DUNNINGTON, E.A. and SIEGEL, P.B. (1997) Genetic architecture of antibody responses of chickens to sheep red blood cells. Journal of Animal Breeding and Genetics 14: 443-449.CrossRefGoogle Scholar
BOA-AMPONSEM, K., PRICE, S.E.H., PICARD, M., GERAERT, P.A. and SIEGEL, P.B. (2000) Vitamin E and immune responses of broiler pure line chickens. Poultry Science 79: 466-470.CrossRefGoogle Scholar
BOREN, B. and BOND, P. (1996) Vitamin E and immunocompetence. Broiler Industry 9: 26-33.Google Scholar
CHEEMA, M.A., QURESHI, M.A. and HAVENSTEIN, G.B. (2003) A Comparison of the Immune Response of a 2001 Commercial Broiler with a 1957 Random bred Broiler Strain When Fed Representative 1957 and 2001 Broiler Diets. Poultry Science 82: 1519-1529.CrossRefGoogle Scholar
CHENG, S. and LAMONT, S.J. (1988) Genetic analysis of immunocompetence measures in a white leghorn chicken line. Poultry Science 67: 989-995.CrossRefGoogle Scholar
COLNAGO, G.L., JENSEN, L.S. and LONG, P.L. (1984) Effect of selenium and vitamin E on the development of immunity to coccidiosis in chickens. Poultry Science 63: 1136-1143.CrossRefGoogle ScholarPubMed
DIBNER, J.J. and RICHARDS, J.D. (2004) The digestive system: challenges and opportunities. Journal of Applied Poultry Research 13: 86-93.CrossRefGoogle Scholar
DIETERT, R.R., MARSH, J.A. and JR.COMBS, G.F. (1983) Influence of dietary selenium and vitamin E on the activity of chicken blood phagocytes. Poultry Science 62: 1412.Google Scholar
DIETERT, R.R. and GOLEMBOSKI, K.A. (1998) Avian macrophage metabolism. Poultry Science 77: 990-997.CrossRefGoogle ScholarPubMed
ERF, G.F. and BOTTJE, W.G. (1996) Nutrition and immune function in chickens: Benefits of dietary vitamin E supplementation. Pages 113–130 in Proceedings of the Arkansas Nutrition Conference, Fayetteville, AR.Google Scholar
ERF, G.F., BOTTJE, W.G., BERSI, T.K., HEADRICK, M.D. and FRITTS, C.F. (1998) Effects of dietary vitamin E on the immune system of broilers: Altered proportions of CD4 T cells in the thymus and spleen. Poultry Science 77: 529-537.CrossRefGoogle ScholarPubMed
FRIEDMAN, A., BARTOV, I. and SKLAN, D. (1998) Humoral immune response impairment following excess vitamin E nutrition in the chick and turkey. Poultry Science 77: 956-962.CrossRefGoogle ScholarPubMed
GERSHWIN, M., BEACH, R. and HURLEY, L. (1985) The potent impact of nutritional factors on immune response. Pages 1-7 in: Nutrition and Immunity. Academic Press, New York, NY.CrossRefGoogle Scholar
GLICK, B. (1995) The immune system of poultry, in: HUNTON, P. (Ed.), World Animal Science C9: Poultry Production, Vol. 32, pp. 483-524 (Elsevier, New York, NY).Google Scholar
GORE, A.B. and QURESHI, V. (1997) Enhancement of humoral and cellular immunity by vitamin E after embryonic exposure. Poultry Science 76: 984-991.CrossRefGoogle ScholarPubMed
GROSS, W.B. and SIEGEL, H.S. (1983) Evaluation of the heterophil/lymphocyte ratio as a measure of stress in chickens. Avian Diseases 27: 972-979.CrossRefGoogle ScholarPubMed
HUSSAIN, I. and QURESHI, M.A. (1997) Nitric oxide synthase and mRNA expression in chicken macrophages. Poultry Science 76: 1524-1530.CrossRefGoogle ScholarPubMed
KLASING, K.C. (1998) Nutritional modulation of resistance to infectious diseases. Poultry Science 77: 1119-1125.CrossRefGoogle ScholarPubMed
KHAN, R.U. (2011) Antioxidants and poultry semen quality. World's Poultry Science Journal 67: 297-308.CrossRefGoogle Scholar
KONJUFCA, V.K., BOTTJE, W.G., BERSI, T.K. and ERF, G.F. (2004) Influence of Dietary Vitamin E on Phagocytic Functions of Macrophages in Broilers. Poultry Science 83: 1530-1534.CrossRefGoogle ScholarPubMed
LESHCHINSKY, T.V. and KLASING, K.C. (2001) Relationship Between the Level of Dietary Vitamin E and the Immune Response of Broiler Chickens. Poultry Science 80: 1590-1599.CrossRefGoogle ScholarPubMed
LIKOFF, R.O., GUPTILL, D.R., LAWRENCE, L.M., MCKAY, C.C., MATHIAS, M.M., NOCKELS, C.F. and TENGERDY, R.P. (1981) Vitamin E and aspirin depress prostaglandins in protection of chickens against E. coli infection. American Journal of Clinical Nutrition, 34: 245-251.CrossRefGoogle Scholar
MARSH, J.A., JRCOMBS, G.F., WHITACRE, M.E. and DIETERT, R.R. (1986) Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development. Proceeding of the Society for Experimental Biology and Medicine 182: 425-436.CrossRefGoogle ScholarPubMed
MARSH, J.A., DIETERT, R.R. and COMBS, G.F. (1981) Influence of dietary selenium and vitamin E on the humoral immune response of chicks. Proceedings of the Society for Experimental Biology and Medicine 166: 228-236.CrossRefGoogle Scholar
MASHALY, M.M., HENDRICKS, G.L., KALAMA, M.A., GEHAD, A.E., ABBAS, A.O. and PATTERSON, P.H. (2004) Effect of Heat Stress on Production Parameters and Immune Responses of Commercial Laying Hens. Poultry Science 83: 889-894.CrossRefGoogle ScholarPubMed
NIU, Z.Y., LIU, F.Z., YAN, Q.L. and LI, W.C. (2009) Effects of different levels of vitamin E on growth performance and immune responses of broilers under heat stress. Poultry Science 88: 2101-2107.CrossRefGoogle ScholarPubMed
NRC, (1994) Nutrient requirements of domestic animals. 9th ed. Washington, DC.Google Scholar
PACKER, L. and SUZUKI, Y. (1993) Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NF-κB transcription factor. Molecular Aspects of Medicine 14: 229-239.CrossRefGoogle Scholar
QURESHI, M.A. and JRTAYLOR, R.L. (1993) Analysis of macrophage function in Rous sarcoma-induced tumour regressor and progressor 6.B congenic chickens. Veterinary Immunology and Immunopathology 37: 285-294.CrossRefGoogle ScholarPubMed
QURESHI, M.A., HUSSAIN, I. and HEGGEN, C.L. (1998) Understanding Immunology in Disease Development and Control. Poultry Science 77: 1126-1129.CrossRefGoogle ScholarPubMed
QURESHI, M.A., HEGGEN, C.L. and HUSSAIN, I. (2000) Avian macrophage: Effect or functions in health and disease. Developmental and Comparative Immunology 24: 103-119.CrossRefGoogle ScholarPubMed
SAKAMOTO, M.I., MURAKAMI, A.E., SILVEIRA, J.I.M., FERNANDES, T.G.V., OLIVEIRA, J.I.M. and DE, C.A.L. (2006) Influence of Glutamine and Vitamin E on the Performance and the Immune Responses of Broiler Chickens. Brazilian Journal of Poultry Science 8: 243-249.CrossRefGoogle Scholar
SELL, J.L., SOTO-SALANOVA, M.F., PALO, M.F. and JEFFREY, M. (1997) Influence of supplementing corn-soybean meal diets with vitamin E on performance and selected physiological traits of male turkeys. Poultry Science 76: 1405-1417.CrossRefGoogle ScholarPubMed
SHEFFY, B.E. and SCHULTZ, R.D. (1979) Influence of vitamin E and selenium on immune response mechanisms. Feed Processing 38: 2139-2143.Google ScholarPubMed
SIEGEL, P.B., LARSEN, C.T., EMMERSON, D.A., GERAERT, P. and PICARD, M. (2000) Feeding regimen, dietary vitamin E, and genotype influence on immunological and production traits of broilers. Journal of Applied Poultry Research 9: 269-278.CrossRefGoogle Scholar
TANAKA, J., FUJAWARA, H. and TORISU, M. (1979) Vitamin E and immune response. 1. Enhancement of helper T-cell activity by dietary supplementation of vitamin E in mice. Immunology 38: 727-734.Google Scholar
TENGERDY, R.P. and NOCKELS, C.F. (1975) Vitamin E or vitamin A protects chickens against E. coli infection. Poultry Science 54: 1294-1296.CrossRefGoogle ScholarPubMed
WEINSTOCK, D., SCHAT, K.A. and CALNEK, B.W. (1989) Avian intestinal immunity. Critical Review of Poultry Biology 3: 19-34.Google Scholar
YANG, N., DUNNINGTON, E.A. and SIEGEL, P.B. (1999) Kinetics of antibody responses in hens from chicken lines divergently selected for response to SRBC. Poultry Science 78: 1081-1084.CrossRefGoogle Scholar
YANG, N., LARSEN, C.T., DUNNINGTON, E.A., GERAERT, P.A., PICARD, M. and SIEGEL, P.B. (2000) Immune competence of chicks from two lines divergently selected for antibody response to sheep red blood cells as affected by supplemental vitamin E. Poultry Science 79: 799-803.CrossRefGoogle ScholarPubMed