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Necrotic enteritis; current knowledge and diet-related mitigation

Published online by Cambridge University Press:  07 March 2017

L.J. BROOM*
Affiliation:
Anpario PLC, Manton Wood Enterprise Park, Worksop, Nottinghamshire, S80 2RS, United Kingdom;Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
*
Corresponding author: leon.broom@anpario.com
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Abstract

Necrotic enteritis (NE) has become one of the most important diseases of modern global poultry production, with an estimated cost of around US$6 billion per annum in lost production and control strategies. The rise in prominence of NE is attributed to the prohibition of antibiotics as growth promoters (AGP) or the voluntary implementation of ‘drug-free’ broiler production programmes. Pathogenic strains of Clostridium perfringens are responsible for NE, with those expressing the NetB toxin a definitive cause in disease models. C. perfringens are normal inhabitants of the gastrointestinal tract (GIT) but these are typically non-pathogenic strains. When intestinal health is compromised, the prevailing conditions allow the establishment and proliferation of pathogenic, toxin-secreting strains of C. perfringens. The toxin(s) damages the intestinal epithelium and causes disease. Certain dietary-related factors are recognised as predisposing poultry to NE. This review will focus on the key initiators of NE and will outline the most appropriate strategies to counteract these predisposing factors and prevent NE. The continual push, globally, for poultry production programmes with less antibiotic use will sustain NE as an important and costly poultry disease that requires dietary intervention.

Type
Reviews
Copyright
Copyright © World's Poultry Science Association 2017 

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References

AJUWON, K.M. (2016) Toward a better understanding of mechanisms of probiotics and prebiotics action in poultry species. Journal of Applied Poultry Research 25: 277-283.Google Scholar
ALASSANE-KPEMBI, I., KOLF-CLAUW, M., GAUTHIER, T., ABRAMI, R., ABIOLA, F.A., OSWALD, I.P. and PUEL, O. (2013) New insights into mycotoxin mixtures: The toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicology and Applied Pharmacology 272: 191-198.Google Scholar
ANNETT, C.B., VISTE, J.R., CHIRINO-TREJO, M., CLASSEN, H.L., MIDDLETON, D.M. and SIMKO, E. (2002) Necrotic enteritis: effect of barley, wheat and corn diets on proliferation of Clostridium perfringens type A. Avian Pathology 31: 598-601.Google Scholar
ANTONISSEN, G., CROUBELS, S., PASMANS, F., DUCATELLE, R., EECKHAUT, V., DEVREESE, M., VERLINDEN, M., HAESEBROUCK, F., EECKHOUT, M., DE SAEGER, S., ANTLINGER, B., NOVAK, B., MARTEL, A. and VAN IMMERSEEL, F. (2015) Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis. Veterinary Research 46: 98.Google Scholar
ANTONISSEN, G., VAN IMMERSEEL, F., PASMANS, F., DUCATELLE, R., HAESEBROUCK, F., TIMBERMON, L., VERLINDEN, M., JANSSENS, G.P.J., EECKHAUT, V., EECKHOUT, M., DE SAEGER, S., HESSENBERGER, S., MARTEL, A. and CROUBELS, S. (2014a) The mycotoxin deoxynivalenol predisposes for the development of Clostridium perfringens-induced necrotic enteritis in broiler chickens. PLoS One 9: e108775.Google Scholar
ANTONISSEN, G., MARTEL, A., PASMANS, F., DUCATELLE, R., VERBRUGGHE, E., VANDENBROUCKE, V., LI, S., HAESEBROUCK, F., VAN IMMERSEEL, F. and CROUBEL, S. (2014b) The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases. Toxins 6: 430-452.Google Scholar
BACH KNUDSEN, K.E. (1997) Carbohydrate and lignin contents of plant materials used in animal feeding. Animal Feed Science and Technology 67: 319-338.Google Scholar
BEDFORD, M.R. and CLASSEN, H.L. (1992) Reduction of intestinal viscosity through manipulation of dietary rye and pentosanase concentration is effected through changes in the carbohydrate composition of the intestinal aqueous phase and results in improved growth rate and food conversion efficiency. Journal of Nutrition 122: 560-569.Google Scholar
BRANTON, S.L., LOTT, B.D., DEATON, J.W., MASLIN, W.R., AUSTIN, F.W., POTE, L.M., KEIRS, R.W., LATOUR, M.A. and DAY, E.J. (1997) The effect of added complex carbohydrates or added dietary fiber on necrotic enteritis lesions in broiler chickens. Poultry Science 76: 24-28.Google Scholar
BROOM, L.J. (2015a) Mycotoxins and the intestine. Animal Nutrition 1: 262-265.Google Scholar
BROOM, L.J. (2015b) Organic acids for improving intestinal health of poultry. World's Poultry Science Journal 71: 630-642.Google Scholar
BURT, S.A., TERSTEEG-ZIJDERVELD, M.H.G., JONGERIUS-GORTEMAKER, B.G.M., VERVELDE, L. and VERNOOIJ, J.C.M. (2013) In vitro inhibition of Eimeria tenella invasion of epithelial cells by phytochemicals. Veterinary Parasitology 191: 374-378.Google Scholar
CALY, D.L., D'INCA, R., AUCLAIR, E. and DRIDER, D. (2015) Alternatives to antibiotics to prevent necrotic enteritis in broiler chickens: A Microbiologist's Perspective. Frontiers in Microbiology 1: 1336.Google Scholar
CHALMERS, G., BRUCE, H.L., HUNTER, D.B., PARREIRA, V.R., KULKARNI, R.R., JIANG, Y.F., PRESCOTT, J.F. and BOERLIN, P. (2008) Multi-locus sequence typing analysis of Clostridium perfringens isolates from necrotic enteritis outbreaks in broiler chickens populations. Journal of Clinical Microbiology 46: 3957-3964.Google Scholar
CHAPMAN, H.D. and JEFFERS, T.K. (2014) Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production. International Journal for Parasitology: Drugs and Drug Resistance 4: 214-217.Google Scholar
COLLETT, S.R. (2012) Nutrition and wet litter problems in poultry. Animal Feed Science and Technology 173: 65-75.Google Scholar
COOPER, K.K. and SONGER, J.G. (2009) Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A. Anaerobe 15: 55-60.Google Scholar
COURSODON, C.F., GLOCK, R.D., MOORE, K.L., COOPER, K.K. and SONGER, J.G. (2012) TpeL-producing strains of Clostridium perfringens type A are highly virulent for broiler chicks. Anaerobe 18: 117-121.Google Scholar
DAHIYA, J.P., HOEHLER, D., VAN KESSEL, A.G. and DREW, M.D. (2007) Dietary encapsulated glycine influences Clostridium perfringens and lactobacilli growth in the gastrointestinal tract of broiler chickens. Journal of Nutrition 137: 1408-1414.Google Scholar
DEBICKI-GARNIER, A.M. and HRUBY, M. (2003) The effect of phytase and betaine on broiler performance and excreta characteristics. Proceedings of the 14th European Symposium of Poultry Nutrition, Norway, pp. 14-15.Google Scholar
DREW, M.D., SYED, N.A., GOLDADE, B.G., LAARVELD, B. and VAN KESSEL, A.G. (2004) Effects of dietary protein source and level on intestinal populations of Clostridium perfringens in broiler chickens. Poultry Science 83: 414-420.Google Scholar
DUNLOP, M.W. MOSS, A.F., GROVES, P.J., WILKINSON, S.J., STUETZ, R.M. and SELLE, P.H. (2016) The multidimensional causal factors of ‘wet litter’ in chicken-meat production. Science of the Total Environment 562: 766-776.Google Scholar
GAUCHER, M.L., QUESSY, S., LETELLIER, A., ARSENAULT, J. and BOULIANNE, M. (2015) Impact of a drug-free program on broiler chicken growth performances, gut health, Clostridium perfringens and Campylobacter jejuni occurrences at the farm level. Poultry Science 94: 1791-1801.Google Scholar
GIRISH, C.K. and SMITH, T. (2008) Impact of feed-borne mycotoxins on avian cell-mediated and humoral immune responses. World Mycotoxin Journal 1: 105-121.Google Scholar
GRAYSTONE, E., KHODAMBASHI EMAMI, N. and BROOM, L.J. (2016) Effects of organic acids on broiler digesta pH and intestinal SCFA concentrations. Proceedings of the International Poultry Scientific Forum, Atlanta, p. 41.Google Scholar
HARRINGTON, D., KONSTANTI, A.E., MATHIS, G.F. and BROOM, L.J. (2016) Oregano essential oil improves performance in coccidiosis-vaccinated broilers. Poultry Science 95 (E-Suppl. 1): p. 82.Google Scholar
JIA, W., SLOMINSKI, B.A., BRUCE, H.L., BLANK, G., CROW, G. and JONES, O. (2009) Effects of diet type and enzyme addition on growth performance and gut health of broiler chickens during subclinical Clostridium perfringens challenge. Poultry Science 88: 132-140.Google Scholar
KALDHUSDAL, M. and SKJERVE, E. (1996) Association between cereal contents in the diet and incidence of necrotic enteritis in broiler chickens in Norway. Preventive Veterinary Medicine 28: 1-16.Google Scholar
KALDHUSDAL, M., BENESTAD, S. and LOYLAND, A. (2016) Epidemiologic aspects of necrotic enteritis in broiler chickens - disease occurrence and production performance. Avian Pathology 45: 271-274.Google Scholar
KEYBURN, A.L., BOYCE, J.D., VAZ, P., BANNAM, T.L., FORD, M.E., PARKER, D., DI RUBBO, A., ROOD, J.I. and MOORE, R.J. (2008) NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathogens 4: e26.Google Scholar
KHODAMBASHI EMAMI, N., GRAYSTONE, E.N., DANESHMAND, A., AKBARI MOGHADDAM KAKHKI, R. and BROOM, L.J. (2016) Boosting gut health and nutrient digestibility by feeding organic acid based products to broilers orally challenged with E. coli K88. Proceedings of the International Poultry Scientific Forum, Atlanta, p. 32.Google Scholar
KLEESSEN, B., HARTMANN, L. and BLAUTl, M. (2003) Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats. British Journal of Nutrition 89: 597-606.Google Scholar
KONDO, F. (1988) In vitro lecithinase activity and sensitivity to 22 antimicrobial agents of Clostridium perfringens isolated from necrotic enteritis of broiler chickens. Research in Veterinary Science 45: 337-340.Google Scholar
KONSTANTI, A.E., BROOM, L.J., OWUSU-ASIEDU, A., HARRINGTON, D. and GIANNENAS, I. (2016) Commercial oregano product increases intestinal cell proliferation, antioxidant capability and performance of broilers. Poultry Science 95 (E-Suppl. 1): pp. 82.Google Scholar
KUMAR, V., SINHA, A.K., MAKKAR, H.P., DE BOECK, G. and BECKER, K. (2012) Dietary roles of non-starch polysaccharides in human nutrition: a review. Critical Reviews in Food Science and Nutrition 52: 899-935.Google Scholar
LACEY, J.A., JOHANESEN, P.A., LYRAS, D. and MOORE, R.J. (2016) Genomic diversity of necrotic enteritis-associated strains of Clostridium perfringens: a review. Avian Pathology 45: 302-307.Google Scholar
LEE, J.T., ECKERT, N.H., AMEISS, K.A., STEVENS, S.M., ANDERSON, P.N., ANDERSON, S.M., BARRI, A., MCELROY, A.P., DANFORTH, H.D. and CALDWELL, D.J. (2011) The effect of dietary protein level on performance characteristics of coccidiosis vaccinated and nonvaccinated broilers following mixed-species Eimeria challenge. Poultry Science 90: 1916-1925.Google Scholar
LEVKUT, M., MARCIN, A., REVAJOVA, V., LENHARDT, L. DANIELOVIC, I., HECL, J., BLANAR, J., LEVKUTOV, M. and PISTL, J. (2011) Influence of oregano extract on the intestine, some plasma parameters and growth performance in chickens. Acta Veterinaria 61: 215-225.Google Scholar
MARESCA, M. (2013) From the gut to the brain: journey and pathophysiological effects of the food associated trichothecene mycotoxin deoxynivalenol. Toxins 5: 784-820.Google Scholar
LIU, D., GUO, S.S. and GUO, Y.M. (2012) Xylanase supplementation to a wheat-based diet alleviated the intestinal mucosal barrier impairment of broiler chickens challenged by Clostridium perfringens . Avian Pathology 41: 291-298.Google Scholar
MOHITI-ASLI, M. and GHANAATPARAST-RASHTI, M. (2015) Dietary oregano essential oil alleviates experimentally induced coccidiosis in broilers. Preventive Veterinary Medicine 120: 195-202.Google Scholar
MOORE, R.J. (2016) Necrotic enteritis predisposing factors in broiler chickens. Avian Pathology 45: 275-281.Google Scholar
PALLIYEGURU, M.W.C.D., ROSE, S.P. and MACKENZIE, A.M. (2011) Effect of trypsin inhibitor activity in soya bean on growth performance, protein digestibility and incidence of sub-clinical necrotic enteritis in broiler chicken flocks. British Poultry Science 52: 359-367.Google Scholar
PRESCOTT, J.F., PARREIRA, V., GOHARI, M., LEPP, D. and GONG, J. (2016) The pathogenesis of necrotic enteritis in chickens: what we know and what we need to know. Avian Pathology 45: 288-294.Google Scholar
RAVINDRAN, V., COWIESON, A.J. and SELLE, P.H. (2008) Influence of dietary electrolyte balance and microbial phytase on growth performance, nutrient utilization and excreta quality of broiler chickens. Poultry Science 87: 677-688.Google Scholar
RIDDELL, C. and KONG, X.M. (1992) The influence of diet on necrotic enteritis in broiler chickens. Avian Diseases 36: 499-503.Google Scholar
SACRANIE, A., IJI, P.A., MIKKELSEN, L.L. and CHOCT, M. (2007) Occurrence of reverse peristalsis in broiler chickens. Proceedings of the Australian Poultry Science Symposium 19: 161-164.Google Scholar
SACRANIE, A., SVIHUS, B. and IJI, P.A. (2012) The effect of digesta viscosity on transit times and gut motility in broiler chickens. Proceedings of the 23rd Annual Australian Poultry Science Symposium, Sydney, pp. 60-64.Google Scholar
SAINI, R., DAVIS, S. and DUDLEY-CASH, W. (2003a) Oregano essential oil reduces the expression of coccidiosis in broilers. Proceeding of the 52nd Conference on Western Poultry Diseases, Sacramento, pp. 97-98.Google Scholar
SAINI, R., DAVIS, S. and DUDLEY-CASH, W. (2003b) Oregano essential oil reduces necrotic enteritis in broilers. Proceeding of the 52nd Conference on Western Poultry Diseases, Sacramento, pp. 95-97.Google Scholar
SELLE, P.H., RAVINDRAN, V. and PARTRIDGE, G.G. (2009) Beneficial effects of xylanase and/or phytase inclusions on ileal amino acid digestibility, energy utilisation, mineral retention and growth performance in wheat-based broiler diets. Animal Feed Science and Technology 153: 303-313.Google Scholar
SELLE, P.H. and RAVINDRAN, V. (2007) Microbial phytase in poultry nutrition. Animal Feed Science and Technology 135: 1-41.Google Scholar
SHOJADOOST, B., VINCE, A.R. and PRESCOTT, J.F. (2012) The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review. Veterinary Research 43: 74-86.Google Scholar
SHIMIZU, T., OHTANI, K., HIRAKAWA, H., OHSHIMA, K., YAMASHITA, A., SHIBA, T., OGASAWARA, N., HATTORI, M., KUHARA, S. and HAYASHI, H. (2002) Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proceedings of the National Academy of Sciences 99: 996-1001.Google Scholar
SMITH, J.A. (2011) Experiences with drug-free broiler production. Poultry Science 90: 2670-2678.Google Scholar
SMYTH, J.A. (2016) Pathology and diagnosis of necrotic enteritis: is it clear-cut? Avian Pathology 45: 282-287.Google Scholar
SONGER, J.G. (1996) Clostridial enteric diseases of domestic animals. Clinical Microbiology Reviews 9: 216-234.Google Scholar
STREIT, E., SCHWAB, C., SULYOK, M., NAEHRER, K., KRSKA, R. and SCHATZMAYR, G. (2013) Multi-mycotoxin screening reveals the occurrence of 139 different secondary metabolites in feed and feed ingredients. Toxins 5: 504-523.Google Scholar
TIMBERMONT, L., LANCKRIET, A., DEWULF, J., NOLLET, N., SCHWARZER, K., HAESEBROUCK, F., DUCATELLE, R. and VAN IMMERSEEL, F. (2010) Control of Clostridium perfringens - induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. Avian Pathology 39: 117-121.Google Scholar
TITBALL, R.W., NAYLOR, C.E. and BASAK, A.K. (1999) The Clostridium perfringens α-toxin. Anaerobe 5: 51-64.Google Scholar
TARANU, I., BRAICU, C., MARIN, D.E., PISTOL, G.C., MOTIU, M., BALACESCU, L., BERIDAN NEAGOE, I. and BURLACU, R. (2015) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression. Toxicology Letters 232: 310-325.Google Scholar
TSINAS, A., GIANNENAS, I., VOIDAROU, C., TZORA, A. and SKOUFOS, J. (2011) Effects of an oregano based dietary supplement on performance of broiler chickens experimentally infected with Eimeria acervulina and Eimeria maxima . Journal of Poultry Science 48: 194-200.Google Scholar
VAN DER KLIS, J. and DE LANGE, L. (2013) Water intake of poultry. 19th European Symposium on Poultry Nutrition, Germany. http://www.wpsa.com/index.php/wpsa-proceedings/2013/19th-european-symposium-on-poultry-nutrition/1375-water-intake-of-poultry/file.Google Scholar
VAN IMMERSEEL, F., DE BUCK, J., PASMANS, F., HUYGHEBAERT, G., HAESEBROUCK, F. and DUCATELLE, R. (2004) Clostridium perfringens in poultry: an emerging threat for animal and public health. Avian Pathology 33: 537-49.Google Scholar
VAN IMMERSEEL, F., LYHS, U., PEDERSEN, K. and PRESCOTT, J.F. (2016) Recent breakthroughs have unveiled the many knowledge gaps in Clostridium perfringens-associated necrotic enteritis in chickens: the first International Conference on Necrotic Enteritis in Poultry. Avian Pathology 45: 269-270.Google Scholar
VAN IMMERSEEL, F., ROOD, J.I., MOORE, R.J. and TITBALL, R.W. (2009) Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends in Microbiology 17: 32-36.Google Scholar
VAN WAEYENBERGHE, L., DE GUSSEM, M., VERBEKE, J., DEWAELE, I. and DE GUSSEM, J. (2016) Timing of predisposing factors is important in necrotic enteritis models. Avian Pathology 45: 370-375.Google Scholar
WADE, B. and KEYBURN, A. (2015) The true cost of necrotic enteritis. World Poultry 31: 16-17.Google Scholar
WIDYARATNE, G.P. (2012) The role of protein and amino acid nutrition in controlling Clostridium perfringens in the gastrointestinal tract of broiler chickens. Ph. D. Thesis, University of Saskatchewan.Google Scholar
WILKIE, D.C., VAN KESSEL, A.G., WHITE, L., LAARVELD, B. and DREW, M.D. (2005) Dietary amino acids affect intestinal Clostridium perfringens populations in broiler chickens. Canadian Journal of Animal Science 85: 185-193.Google Scholar
WILLIAMS, R.B. (2005) Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian Pathology 34: 159-180.Google Scholar
WU, S.B., STANLEY, D., RODGERS, N., SWICK, R.A. and MOORE, R.J. (2014) Two necrotic enteritis predisposing factors, dietary fishmeal and Eimeria infection, induce large changes in the caecal microbiota of broiler chickens. Veterinary Microbiology 169: 188-197.Google Scholar