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Selenium in poultry nutrition 1. Antioxidant properties, deficiency and toxicity

Published online by Cambridge University Press:  18 September 2007

P.F. Surai
P.F. Surai
Affiliation:
Avian Science Research Centre, SAC, Auchincruive, Ayr, KA6 SHW, Scotland, e-mail: p.surai@au.sac.ac.uk
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Abstract

Selenium (Se) has a special place among the feed-derived natural antioxidants, being an integral part of selenoproteins participating in the regulation of various physiological processes in the body. As a part of glutathione peroxidase (GSH-Px) Se belongs to the first and second major levels of antioxidant defence in the cell. There are two major sources of Se for poultry organic selenium, mainly in the form of selenomethionine (SeMet), which can be found in any feed ingredient in varying concentrations and inorganic selenium, mainly selenite or selenate, which are widely used for dietary supplementation. There is a principal difference in metabolism and efficiency of these two forms of selenium, with SeMet being more effective. In fact SeMet possesses antioxidant properties, however, in some conditions selenite can be a pro-oxidant. Se deficiency and excess in modern poultry production are very rare. In general, adequate Se supplementation is considered to be a crucial factor in maintaining the high productive and reproductive characteristics of commercial poultry.

Keywords

SeleniumSelenomethionineantioxidantprooxidantchickentoxicity
Type
Reviews
Information
World's Poultry Science Journal , Volume 58 , Issue 3 , September 2002 , pp. 333 - 347
Copyright
Copyright © Cambridge University Press 2002

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References

Akulov, A.V., Minina, L.a., Andreev, M.N., Tomskikh, Yu.I., Bronnikova, K.A. and Korenkov, I.P. (1972) Experimental selenium poisoning in hens. Sel'skokhozyaistvennaya Biologiya 7: 430–436.Google Scholar
Ames, B.N. (1983) Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221: 1256–1264.CrossRefGoogle ScholarPubMed
Arner, E.S. and Holmgren, A. (2000) Physiological functions of thioredoxin and thioredoxin reductase. European Journal of Biochemistry 267: 6102–6109.CrossRefGoogle ScholarPubMed
Assmann, A., Briviba, K. and Sies, H. (1998) Reduction of methionine selenoxide to selenomethionine by glutathione. Archive Biochemistry and Biophysics 349: 201–203.CrossRefGoogle ScholarPubMed
Aw, T.Y. (1999) Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine. American Journal of Clinical Nutrition 70: 557–565.CrossRefGoogle ScholarPubMed
Aw, T.Y. (1998) Determinants of intestinal detoxication of lipid hydroperoxides. Free Radical Research 28: 637–646.CrossRefGoogle ScholarPubMed
Bartholomew, A., Latshaw, D. and Swayne, D.E. (1998) Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks. Biological Trace Element Research 62: 7–16.CrossRefGoogle ScholarPubMed
Bottje, W.G. and Wideman, R.F. (1995) Potential role of free radicals in the pathogenesis of pulmonary hypertension syndrome. Poultry and Avian Biology Reviews 6: 211–231.Google Scholar
Brigelius-Flohe, R. (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radical Biology and Medicine 27: 951–965.CrossRefGoogle ScholarPubMed
Briviba, K., Roussyn, I., Sharov, V.S. and Sies, H. (1996) Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen. Biochemical Journal 319: 13–15.CrossRefGoogle ScholarPubMed
Brody, T. (1994) Nutritional Biochemistry. Academic Press, Inc. New York, NY.Google Scholar
Cantor, A.H., Langevin, M.L., Noguchi, T. and Scott, M.L. (1975) Efficiency of selenium compounds and feedstuffs for prevention of pancreatic fibrosis in chick. Journal of Nutrition 105: 106–111.CrossRefGoogle Scholar
Cantor, A.H., Moorhead, P.D. and Brown, K.I. (1978) Influence of dietary selenium upon reproductive performance of male and female breeder turkey. Poultry Science 57: 1337–1345.CrossRefGoogle Scholar
Cantor, A.H. and Scott, M.L. (1974) The effect of selenium in the hen's diet on egg production, hatchability, performance of progeny and selenium concentration in eggs. Poultry Science 53: 1870–1880.CrossRefGoogle ScholarPubMed
Century, B. and Hurwitt, M.K. (1964). Effect of dietary selenium on incidence of nutritional encephalomalacia in chicks. Proceedings of the Society for Experimental Biology and Medicine 117: 320.CrossRefGoogle ScholarPubMed
Cheng, W.H., Valentine, B.A. and Lei, X.G. (1999) High levels of dietary vitamin E do not replace cellular glutathione peroxidase in protecting mice from acute oxidative stress. Journal of Nutrition 129: 1951–1957.CrossRefGoogle Scholar
CHO, D.Y., Jung, U. and Chung, A.S. (1999) Induction of apoptosis by selenite and selenodiglutathione in HL-60 cells: correlation with cytotoxicity. Biochemistry and Molecular Biology International 47: 781–793.Google ScholarPubMed
Combs, G.F. Jr. (1994) Clinical Implications of selenium and vitamin E in poultry nutrition. Veterinary Clinical Nutrition 1: 133–140.Google Scholar
Combs, G.F. and Combs, S.B. (1984) The nutritional biochemistry of selenium. Annual Review of Nutrition 4: 257–280.CrossRefGoogle ScholarPubMed
Combs, G.F. and Hady, M.M. (1991) Selenium involved with vitamin E in preventing encephalomalacia in the chick. FASEB Journal 5: A714.Google Scholar
Combs, G.F. Jr. and Scott, M.L. (1977) The selenium needs of laying and breeding hens. Proceedings of the Cornell Nutrition Conference74–82Google Scholar
Csallny, As., Su, L.C. and Menken, B.Z. (1984) Effect of selenite, vitamin E and N,N'-diphenyl-p-phenylenediamine on liver organic solvent-soluble lipofuscin pigments in mice. Journal of Nutrition 114: 1582–1587.CrossRefGoogle Scholar
Diplock, A.T. (1994) Antioxidants and disease prevention. Molecular Aspects of Medicine 15: 295–376.CrossRefGoogle ScholarPubMed
Diplock, A.T., Charleux, J.L., Crozier-Willi, G., Kok, F.J., Rice-Evans, C., Roberfroid, M., Stahl, W. and Vina-Ribes, J. (1998) Functional food science and defence against reactive oxidative species. British Journal of Nutrition 80 (Suppl 1): S77–112.CrossRefGoogle ScholarPubMed
Dougherty, J.J. and Hoekstra, W.G. (1982) Stimulation of lipid peroxidation in vivo by injected selenite and lack of stimulation by selenate. Proceedings of the Sociery for Experimental Biology and Medicine 169: 209–215.CrossRefGoogle ScholarPubMed
Edens, F.W. (2001) Involvement of Sel-Plex in physiological stability and performance of broiler chickens. In: Biotechnology in the Feed industry. Proceedings of Alltech's 17th Annual Symposium (Lyons, T.P. and Jacques, K.A., Eds.). Nottingham University Press, Nottingham. UK, pp. 349–376.Google Scholar
Fico, M.E., Poirier, K.A., Watrach, A.M., Watrach, M.A. and Milner, J.A. (1986) Differential effects of selenium on normal and neoplastic canine mammary cells. Cancer Research 46: 3384–3388.Google ScholarPubMed
Fitzsimmons, R.C. and Phalaraksh, K. (1978) Chick embryonic development as influenced by in ovo injected selenium. Canadian Journal of Animal Science 58: 227–232.CrossRefGoogle Scholar
Flohe, L., Andreesen, J.R., Brigelius-Flohe, R., Maiorino, M. and Ursini, F. (2000) Selenium, the element of the moon, in life on earth. IUBMB Life 49: 411–420.CrossRefGoogle Scholar
Fraga, C.G., Arias, R.F., Llesui, S.F., Koch, O.R. and Boveris, A. (1987) Effect of vitamin E- and selenium-deficiency on rat liver chemiluminescence. Biochemical Journal 242: 383–386.CrossRefGoogle ScholarPubMed
Garberg, P., Stahl, A., Warholm, M., and Hogberg, J. (1988) Studies of the role of DNA fragmentation in selenium toxicity. Biochemical Pharmacology 37: 3401–3406.CrossRefGoogle ScholarPubMed
Green, D.E. and Albers, P.H. (1997) Diagnostic criteria for selenium toxicosis in aquatic birds: Histologic lesions. Journal of Wildlife Diseases 33: 385–404.CrossRefGoogle ScholarPubMed
Gries, C.L. and Scott, M.L. (1972) Pathology of selenium deficiency in the chick. Journal of Nutrition 102: 1287–1296.CrossRefGoogle ScholarPubMed
Gutteridge, J.M.C. and Halliwell, B. (1990) The measurement and metabolism of lipid peroxidation in biological systems. Trends in Biochemical Sciences 15: 129–135.CrossRefGoogle ScholarPubMed
Halliwell, B. and Gutteridge, J.M.C. (1999) Free radical in biology and medicine. Third edition, Oxford University Press, Oxford.Google Scholar
Hassan, S., Hakkarainen, J., Jonsson, M.L. and Tyopponen, J. (1990) Histopathological and biochemical changes associated with selenium and vitamin E deficiency in chicks. Journal of Veterinary Medicine. A, Physiology, pathology, clinical medicine 37: 708–720.CrossRefGoogle ScholarPubMed
Hoffman, D.J., Heinz, G.H., Lecaptain, L.J., Bunck, C.M.and Green, D.E. (1991) Subchronic hepatotoxicity of selenomethionine ingestion in mallard ducks. Journal of Toxicology and Environmental Health 32: 449–464.CrossRefGoogle ScholarPubMed
Hogg, N. (1998) Free radicals in disease. Seminars in Reproduction Endocrinology 16: 241–248.CrossRefGoogle ScholarPubMed
Holmgren, A. (2000) Redox regulation by thioredoxin and thioredoxin reductase. BioFactors 11: 63–64.CrossRefGoogle ScholarPubMed
Hurley, W.L. and Doane, R.M. (1989) Recent developments in the roles of vitamins and minerals in reproduction. Journal of Dairy Science 72: 784–804.CrossRefGoogle ScholarPubMed
Jaeschke, H. ( 1995) Mechanisms of oxidant stress-induced acute tissue injury. Proceedings of the Society for Experimental Biology and Medicine 209: 104–111.CrossRefGoogle ScholarPubMed
Jonsson, L. (1993) The pathology of diseases and diffuse disorders due to selenium deficiency in non-ruminants. Norwegian Journal of Agricultural Sciences (Suppl.) 11: 95–103.Google Scholar
Kaantee, E., Kurkela, P. and Jaakkola, K. (1982) Effects of dietary organic selenium content on fowls, chicks and eggs. Journal of the Scientific Agricultural Society of Finland 54: 113–118.Google Scholar
Khan, M.Z., Szerek, J. and Markiewicz, K. (1993) Effects of oral administration of toxic levels of lead and selenium upon concentration of different elements in the liver of broiler chicks. Journal of Veterinary Medicine. A. Physiology Pathology, Clinical Medicine 40: 652–664.CrossRefGoogle ScholarPubMed
Knight, J.A. (1998) Free radicals: Their history and current status in aging and disease. Annals of clinical and Laboratory Science 28: 331–346.Google ScholarPubMed
Kohrle, J., Brigelius-Flohe, R., Bock, A., Gartner, R., Meyer, O. and Flohe, L. (2000) Selenium in biology: facts and medical perspectives. Biological Chemistry 381: 849–864.CrossRefGoogle Scholar
Kramer, G.F. and Ames, B.N. (1988). Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutation Research 201: 169–180.CrossRefGoogle ScholarPubMed
Latshaw, J.D. and Osman, M. (1974) A selenium and vitamin E responsive condition in the laying hen. Poultry Science 53: 1704–1708.CrossRefGoogle ScholarPubMed
Latshaw, J.D., Ort, J.F. and Diesem, C.D. (1977) The selenium requirements of the hen and effects of a deficiency. Poultry Science 56: 1876–1881.CrossRefGoogle ScholarPubMed
Lu, J., Kaeck, M., Jiang, C., Wilson, A.C. and Thoimpson, H.J. (1994) Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells. Biochemical Pharmacology 47: 1531–1535.CrossRefGoogle ScholarPubMed
Lu, J., Jiang, C., Kaeck, M., Ganther, H., Vadhanavikit, S., Ip, C. and Thompson, H. (1995) Dissociation of the genotoxic and growth inhibitory effects of selenium. Biochemical Pharmacology 50: 213–219.CrossRefGoogle ScholarPubMed
Lu, J., Jiang, C., Kaeck, M., Ganther, H., Ip, C. and Thompson, H. (1995a) Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model. Carcinogenesis 16: 513–517.CrossRefGoogle Scholar
Mahan, D. (1999) Organic selenium: using nature's model to redefine selenium supplementation for animals. In: Biotechnology in the Feed industry. Proceedings of Alltech's 15th Annual Symposium (Lyons, T.P. and Jacques, K.A., Eds.). Nottingham University Press, Nottingham, UK, pp. 523–535.Google Scholar
McDowell, L.R. (2000) Reevaluation of the metabolic essentiality of the vitamins. Asian-Australian Journal of Animal Sciences 13: 115–125.CrossRefGoogle Scholar
Medina, D. and Oborn, C.J. (1981) Differential effects of selenium on the growth of mouse mammary cells in vitro. Cancer Letters 13: 333–344.CrossRefGoogle ScholarPubMed
Menter, D.G., Sabichi, A.L. and Lippman, S.M. (2000) Selenium effects on prostate cell growth. Cancer Epidemiology, Biomarkers and Prevention 9: 1171–1182.Google ScholarPubMed
Miller, D.L., Hanson, W., Schedl, H.P. and Osborne, J.W. (1977) Proliferation rate and transit time of mucosal cells in small intestine of the diabetic rat. Gastroenterology 73: 1326–32.CrossRefGoogle ScholarPubMed
Morrissey, P.A. and O'Brien, N.M. (1998) Dietary antioxidants in human health and disease. International Dairy Journal 8: 463–472.CrossRefGoogle Scholar
Moksenes, K. (1983) Selenium deposition in tissues and eggs of laying hens given surplus of selenium as selenomethionine. Acta Veterinaria Scandinavica 24: 34–44.CrossRefGoogle Scholar
Navarro, F., Arroyo, A., Martin, S.F., Bello, R.I., De Cabo, R., Burgess, J.R., Navas, P. and Villalba, J.M. (1999) Protective role of ubiquinone in vitamin E and selenium-deficient plasma membranes. BioFactors 9: 163–170.CrossRefGoogle ScholarPubMed
Navarro, F., Navas, P., Burgess, J.R., Bello, R.I., De Cabo, R., Arroyo, A and Villalba, J.M. (1998) Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane. FASEB Journal 12: 1665–1673.CrossRefGoogle ScholarPubMed
Noguchi, T., Cantor, A.H. and Scott, M.L. (1973) Mode of action of selenium and vitamin E in prevention of exudative diathesis in chicks. Journal of Nutrition 103: 1502–1511.CrossRefGoogle ScholarPubMed
Olson, O.E. and Palmer, I.S. (1976) Selenoamino acids in tissues of rats administered inorganic selenium. Metabolism 25: 299–306.CrossRefGoogle ScholarPubMed
Ort, J.F. and Latshaw, J.D. (1978) The toxic level of sodium selenite in the diet of laying chickens. Journal of Nutrition 108: 1114–1120.CrossRefGoogle ScholarPubMed
Packer, L. (1992) Interactions among antioxidants in health and disease: Vitamin E and its redox cycle. Proceedings of the Society for Experimental Biology and Medicine 200: 271–276.CrossRefGoogle ScholarPubMed
Pehrson, B. (1993) Selenium in nutrition with special reference to the biopotency of organic and inorganic selenium compounds. In: Biotechnology in the Feed industry. Proceedings of the Alltech's 9th Annual Symposium (Lyons, T.P. and Jacques, K.A., Eds.). Nottingham University Press, Nottingham, UK, pp. 71–89.Google Scholar
Qi, Z. Y., Han, B., Qin, S., Hou, J.W., Dong, Q.A., Zhang, B.X. and Liu, B.F. (1992) The studies of experimental organic selenium toxicosis in growing chickens. Acta Veterinaria et Zootechnica Sinica 123: 281–284.Google Scholar
Rafferty, T.S., McKenzie, R.C., Hunter, J.A., Howie, A.F., Arthur, J.R., Nicol, F. and Beckett, G.J. (1998) Differential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death. Biochemical Journal 332: 231–236.CrossRefGoogle ScholarPubMed
Raisbeck, M.F. (2000) Selenosis. Veterinary Clinics of North America; Food Animal Practice 16: 465–480.CrossRefGoogle Scholar
Reilly, C. (1996) Selenium in food and health. Blackie Academic & Professional, an imprint of Chapman & Hall, London.CrossRefGoogle Scholar
Roussyn, I., Briviba, K., Matsumoto, H. and Sies, H. (1996) Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite. Archives of Biochemistry and Biophysics 330: 216–218.CrossRefGoogle ScholarPubMed
Salyi, G., Banhidi, G., Szabo, E., Gonye, S. and Ratz, F. (1993) Acute selenium poisoning in broilers. Magyar Allatorvosok Lapja 48: 22–26.Google Scholar
Santolo, G.M., Yamamoto, J.T., Pisenti, J.M. and Wilson, B.W. (1999) Selenium accumulation and effects on reproduction in captive American kestrels fed selenomethionine. Journal of Wildlife Management 63: 502–511.CrossRefGoogle Scholar
Schrauzer, G.N. (2000) Selenomethionine: a review of its nutritional significance, metabolism and toxicity. Journal of Nutrition 130: 1653–1656.CrossRefGoogle ScholarPubMed
Seko, Y. and Imura, N. (1997) Active oxygen generation as a possible mechanism of selenium toxicity. Biomedical and Environmental Sciences 10: 333–339.Google ScholarPubMed
Seko, Y., Saito, Y., Kitahara, J. and Imura, N. (1989) Active oxygen generation by the reaction of selenite with reduced glutathione in vitro. In: Selenium in Biology and medicine (Wendel, A., Ed.), Berlin: Springer-Verlag; pp. 70–73.CrossRefGoogle Scholar
Sharov, V.S., Briviba, K.and Sies, H. (1999) Peroxynitrite diminishes gap junctional communication: protection by selenite supplementation. IUBMB Life 48: 379–384.CrossRefGoogle ScholarPubMed
Shen, H., Yang, C., Liu, J. and Ong, C. (2000) Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells. Free Radical Biology and Medicine 28: 1115–1124.CrossRefGoogle ScholarPubMed
Shen, H.M., Yang, C.F. and Ong, C.N. (1999) Sodium selenite-induced oxidative stress and apoptosis in human hepatoma HepG2 cells. International Journal of Cancer 81: 820–828.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Shen, C.L., Song, W. and Pence, B.C. (2001) Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes. Cancer Epidemiology, Biomarkers and Prevention 10: 385–390.Google ScholarPubMed
Sies, H., Klotz, L.O., Sharov, V.S., Assmann, A. and Briviba, K. (1998) Protection against peroxynitrite by selenoproteins. Zeitschrift fur Naturforschung [C] 53: 228–232.CrossRefGoogle ScholarPubMed
Sofetti, M.G., Nebbia, C. and Valenza, F. (1983) Chronic experimental toxicity of cystine selenate in fowls. Clinical and pathological findings. Note 1. Clinica Veterinaria 106: 97–106.Google Scholar
Spallholz, J.E. (1994) On the nature of selenium toxicity and carcinostatic activity. Free Radical Biology and Medicine 17: 45–64.CrossRefGoogle ScholarPubMed
Spallholz, J.E. (1997) Free radical generation by selenium compounds and their prooxidant toxicity. Biomedical and Environmental Sciences 10: 260–270.Google ScholarPubMed
Stewart, M.S., Davis, R.L., Walsh, L.P. and Pence, B.C. (1997) Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Letters 117: 35–40.CrossRefGoogle ScholarPubMed
Stewart, M.S., Spallholz, J.E., Neldner, K.H. and Pence, B.C. (1999) Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radical Biology and Medicine 26: 42–48.CrossRefGoogle ScholarPubMed
Sukra, Y., Sastrohadinoto, S., Budiarso, I.T. and Bird, H.R. (1976) Effect of selenium and mercury on gross morphology and histopathology of chick embryos. Poultry Science 55: 2424–2433.CrossRefGoogle ScholarPubMed
Sun, E., Xu, H., Wen, D., Zuo, P., Zhou, J. and Wang, J. (1997) Inhibition of lipid peroxidation. Biological Trace Element Research 59: 87–92.CrossRefGoogle ScholarPubMed
Sundaram, N., Pahwa, A.K., Ard, M.D., Lin, N., Perkins, E. and Bowles, A.P. Jr. (2000) Selenium causes growth inhibition and apoptosis in human brain tumor cell lines. Journal of Neuro-oncology 46: 125–133.CrossRefGoogle ScholarPubMed
Surai, P.F. (1999) Vitamin E in avian reproduction. Poultry and Avian Biology Reviews 10: 1–60.Google Scholar
Surai, P.F. (2000)Organic selenium: benefits to animals and humans, a biochemist's view. In: Biotechnology in the Feed industry. Proceedings of Alltech's 16th Annual Symposium (Lyons, T.P. and Jacques, K.A., Eds.). Nottingham University Press, Nottingham, UK, pp. 205–260.Google Scholar
Surai, P.F. (2000a) Organic selenium and the egg: Lessons from nature. Feed Compounder 20: 16–18.Google Scholar
Surai, P.F. (2002) Natural antioxidants in Avian Nutrition and Reproduction. Nottingham University Press.Google Scholar
Surai, P.F. and Dvorska, J.E. (2001) Is organic selenium better for animals than inorganic sources? Two different scenarios in stress conditions. Feed Mix 9.4/5: 8–10.Google Scholar
Surai, P.F., Sparks, N.H.C. (2001) Designer eggs: from improvement of egg composition to functional food. Trends in Food Science and Technology 12: 7–16.CrossRefGoogle Scholar
Surai, P.F. and Speake, B.K. (1998) Distribution of carotenoids from the yolk to the tissues of the chick embryo Journal of Nutritional Biochemistry 9:645–651.CrossRefGoogle Scholar
Surai, P.F., Speake, B.K. and Sparks, N.H.C. (2001) Carotenoids in avian nutrition and embryonic development. 1. Absorption, availability and levels in plasma and egg yolk. Journal of Poultry Science 38: 1–27.CrossRefGoogle Scholar
Surai, P.F., Speake, B.K. and Sparks, N.H.C. (2001a) Carotenoids in avian nutrition and embryonic development. 2. Antioxidant properties and discrimination in embryonic tissues Journal of Poultry Science 38: 117–145.CrossRefGoogle Scholar
Terada, A., Yoshida, M., Seko, Y., Kobayashi, T., Yoshida, K., Nakada, M., Nakada, K., Echizen, H., Ogata, H. and Rikihisa, T. (1999) Active oxygen species generation and cellular damage by additives of parenteral preparations: selenium and sulthydryl compounds. Journal of Nutrition 15: 651–655.CrossRefGoogle Scholar
Thompson, J.N. and Scott, M.L. (1969) Role of selenium in the nutrition of the chick. Journal of Nutrition 97: 335–342.CrossRefGoogle ScholarPubMed
Thompson, J.N. and Scott, M.L. (1970) Impaired lipid and vitamin E absorption related to atrophy of the pancreas in selenium-deficient chicks. Journal of Nutrition 100: 797–809.CrossRefGoogle ScholarPubMed
Tishkov, A.I. and Voitov, L.I. (1989) Toxicological characteristics of sodium selenite in poultry. Veterinariya (Moskva) 11: 65–67.Google Scholar
Todorovic, M., Mihalovic, M. and Hristov, S. (1999) Effects of excessive levels of sodium selenite on daily weight gain, mortality and plasma selenium concentration in chickens. Acata Veterinuria-Beograd 49: 313–319.Google Scholar
Vinson, J.A., Stella, J.M. and Flanagan, T.J. (1998) Selenium yeast is an effective in vitro and in vivo antioxidant and hypolipemic agent in normal hamsters. Nutrition Research 18: 735–742.CrossRefGoogle Scholar
Wang, T.G., Gotoh, Y., Jennings, M.H., Rhoads, C.A. and Aw, T.Y. (2000) Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cells is associated with an early loss of cellular redox balance. FASEB Journal 14: 1567–1576.CrossRefGoogle ScholarPubMed
Weiss, W.P. (1998) Requirements of fat-soluble vitamins for dairy cows: A review. Journal of Daiy Science 81: 2493–2501.Google ScholarPubMed
Whanger, P.D. (2000) Selenoprotein W: a review. Cellular and Molecular Life Sciences 57: 1846–1852.CrossRefGoogle ScholarPubMed
Whitacre, M.E., Combs, G.F., Combs, S.B. and Parker, R.S. (1987) Influence of dietary vitamin E on nutritional pancreatic atrophy in selenium-deficient chicks. Journal of Nutrition 117: 460–467.CrossRefGoogle ScholarPubMed
Wingler, K. and Brigelius-Flohe, R., (1999) Gastrointestinal glutathione peroxidase. BioFactors 10: 245–249.CrossRefGoogle ScholarPubMed
Yan, L. and Spallholz, J.E. (1993) Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells. Biochemical Pharmacology 45: 429–437.Google ScholarPubMed
Zalejska-Fiolka, J. (2000) Antioxidative properties of alpha-tocopherol, methionine and selenomethionine in olive oil. Rivista ltaliana delle Sostanze Grasse, 77: 543–547.Google Scholar
Zia, S. and Islam, F. (2000) Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat. Biological Trace Element Research 77: 251–259.CrossRefGoogle ScholarPubMed